Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 GeneticVariation disease BEFREE Analysis of HDGC patients harbouring CDH1 alleles with PTCs at a wide variety of different positions indicates an association of their predicted ability to induce NMD and an earlier age of onset of gastric cancer. 18427545 2008
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 GeneticVariation disease BEFREE Probands from two Danish families with gastric cancer and a history suggesting HDGC were screened for CDH1 gene mutations. 24389957 2014
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 GeneticVariation disease BEFREE CDH1 -160 -AA genotype was associated with an increased risk of GC (OR = 3.6, 95% CI: 1.1-11.8) (P = 0.03). 20632448 2010
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 GeneticVariation disease BEFREE E-cadherin/CDH1 gene methylation is an important cause for its gene silence in diffuse variant gastric carcinoma. 16830381 2006
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 GeneticVariation disease BEFREE Germline CDH1 mutations recently were identified in families with hereditary diffuse gastric carcinoma in a pattern suggestive of autosomal dominant inheritance with incomplete penetrance. 11443625 2001
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 GeneticVariation disease BEFREE The majority of patients with germline CDH1 mutation have foci of noninvasive or invasive gastric cancer by middle age. 20719348 2011
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 GeneticVariation disease BEFREE In meta-analysis, CDH1 -160C>A showed an inverse association with GC among Asians (OR, 0.76; 95% CI, 0.55-1.05) and a positive association among Caucasians (OR, 1.40; 95% CI, 0.95-2.04). 18544073 2008
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 GeneticVariation disease BEFREE A novel diffuse gastric cancer susceptibility variant in E-cadherin (CDH1) intron 2: a case control study in an Italian population. 18482459 2008
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 GeneticVariation disease BEFREE The role of the E-cadherin gene (CDH1) in diffuse gastric cancer susceptibility: from the laboratory to clinical practice. 14630673 2003
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 GeneticVariation disease BEFREE Genetic polymorphisms of the E-cadherin promoter and risk of sporadic gastric carcinoma in Chinese populations. 18768510 2008
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 GeneticVariation disease BEFREE However, three CDH1 polymorphisms in the same haplotype block, including the CDH1-160C/A, interacted with smoking to increase GC risk in smokers but not in never smokers. 18342503 2008
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 GeneticVariation disease BEFREE This study evaluated the effect of PTG on health-related quality of life (HRQL) in asymptomatic individuals with identified CDH1 mutations at high risk for gastric cancer. 24424140 2014
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 GeneticVariation disease BEFREE In conclusion, this meta-analysis suggests that CDH1 -160 A-allele may play a protective role of stomach cancer development in Asians but not in Caucasians. 21625863 2012
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 GeneticVariation disease BEFREE CDH1 somatic alterations were found in approximately 30% of all patients with GC. 23341533 2013
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 GeneticVariation disease BEFREE To examine the frequency of CDH1 germline mutations in a population-based series of early-onset gastric cancer (EOGC <50 years old). 16801346 2006
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 GeneticVariation disease BEFREE Mutations in the CDH1 gene are linked both to diffuse gastric cancer and invasive lobular carcinoma (ILC). 28993866 2018
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 GeneticVariation disease BEFREE These results suggest that the ATCTG and CTTTG CDH1 haplotypes may be associated with an increased risk and decreased risk, respectively, of GC in the Japanese population. 17852867 2007
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 GeneticVariation disease BEFREE This study was aimed to analyse the hypermethylation status of the E-Cadherin (CDH1) gene promoter in GCs in the ethnic Kashmiri population. 27356686 2016
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 GeneticVariation disease BEFREE To our knowledge, this is the first Korean case of presymptomatic detection of CDH1 mutation, and it highlights the importance of genetic screening for individuals with a family history of GC, especially in high-risk geographical areas. 25187893 2014
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 GeneticVariation disease BEFREE CDH1 mutation testing in families with a history of gastric cancer and prophylactic gastrectomy in mutation-positive patients are recommended for the management of HDGC. 22160243 2012
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 GeneticVariation disease BEFREE To give a comprehensive report of E-cadherin gene (CDH1) variations in a population at a high risk for gastric cancer (GC). 23431106 2013
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 GeneticVariation disease BEFREE Participants included one 37-year-old man with multiple polyps in his stomach and a family history of stomach cancer, one 18 year-old man with a confirmed CDH1 mutation and a family history of stomach cancer, and one 33-year-old man with confirmed metastatic gastric adenocarcinoma. 21838951 2011
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 GeneticVariation disease BEFREE Female predominance in early-onset gastric cancer may be related to relatively high rates of somatic CDH1 and TGFBR1 mutations in this population. 28522256 2017
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 GeneticVariation disease BEFREE We detected the epidermal growth factor receptor L858R, MSH2 R929* and telomerase reverse transcriptase amplification in the lung cancer specimen; CDH1 c.1320+1G>T mutation in the gastric cancer (GC) specimen; and MLH1 c.1896+5G>A germline mutation in the lung and GC specimens by 450 cancer-related gene mutations detection using next-generation sequencing technology. 31207149 2019
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 GeneticVariation disease BEFREE In our area, in which a high rate of familial aggregation was demonstrated, the lack of germ line mutation of TP53 together with the infrequency of mutation of E-cadherin gene seem to limit the role of genetic predisposition in the development of gastric cancer. 19674071 2010