<i>Helicobacter pylori (H. pylori)</i> infection leads to gastric inflammation, peptic ulcer and gastric carcinoma.<i>H. pylori</i> activates NADPH oxidase and increases reactive oxygen species (ROS), which induce NF-κB activation and IL-8 expression in gastric epithelial cells.
Altogether, our results shed light on crucial roles of ME1-mediated production of NADPH in gastric cancer growth and metastasis.<b>Significance:</b> These findings reveal the role of malic enzyme in growth and metastasis.<b>Graphical Abstract:</b> http://cancerres.aacrjournals.org/content/canres/78/8/1972/F1.large.jpg <i></i>.