Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 324
Gene Symbol: APC
APC
0.400 GeneticVariation disease BEFREE Advanced GC data suggested that early mutations (APC and TP53) may affect the potential of cancerous progression from D/IEN. 30474112 2019
Entrez Id: 324
Gene Symbol: APC
APC
0.400 Biomarker disease BEFREE Our results also showed that hsa-miR-29c-5p is an important regulator of CDC42 and DNMT3A genes in the intestinal subtype gastric cancer and hsa-miR-135b-5p regulates the APC gene in both intestinal and diffuse subtypes of GC. 30376837 2018
Entrez Id: 324
Gene Symbol: APC
APC
0.400 PosttranslationalModification disease BEFREE The effect of EBV on WIF1, NLK, and APC gene methylation and expression in gastric carcinoma and nasopharyngeal cancer. 28543390 2017
Entrez Id: 324
Gene Symbol: APC
APC
0.400 GeneticVariation disease BEFREE The frequency of genomic alterations seen in SBA demonstrated distinct differences in comparison with either colorectal cancer (APC: 26.8% [85 of 317] vs 75.9% [4823 of 6353], P < .001; and CDKN2A: 14.5% [46 of 317] vs 2.6% [165 of 6353], P < .001) or gastric carcinoma (KRAS: 53.6% [170 of 317] vs 14.2% [126 of 889], P < .001; APC: 26.8% [85 of 317] vs 7.8% [69 of 889], P < .001; and SMAD4: 17.4% [55 of 317] vs 5.2% [46 of 889], P < .001). 28617917 2017
Entrez Id: 324
Gene Symbol: APC
APC
0.400 GeneticVariation disease BEFREE TP53 mutation, allelic deletion of the APC gene and nuclear staining of β-catenin are frequently detected in the intestinal phenotype of GC, whereas CDH1 gene mutation, microsatellite instability and DNA hypermethylation of MLH1 are common events in the gastric phenotype of GC. 26033320 2015
Entrez Id: 324
Gene Symbol: APC
APC
0.400 PosttranslationalModification disease BEFREE Serum RASSF1A and APC promoter hypermethylation is a frequent epigenetic event in patients with early operable gastric cancer. 26073472 2015
Entrez Id: 324
Gene Symbol: APC
APC
0.400 PosttranslationalModification disease BEFREE The aim of this study is to examine the expression of β-catenin, APC and E-cadherin in tumour tissues of 80 Tunisian patients with gastric carcinoma and to determine the methylation status of the APC promoter in tumour tissues. 24197976 2014
Entrez Id: 324
Gene Symbol: APC
APC
0.400 GeneticVariation disease BEFREE Losses of a CNV at 5q22, especially in the DNA region surrounding APC-exon 9, may be associated with a higher risk of gastric cancer. 25210923 2014
Entrez Id: 324
Gene Symbol: APC
APC
0.400 Biomarker disease BEFREE The frequencies in GC serum were 30.67% for APC, 34.67% for WIF-1, 37.33% for RUNX-3, 29.33% for DLC-1, 33.33% for SFRP-1, 32% for DKK, and 26.67% for E-cad. 23049225 2012
Entrez Id: 324
Gene Symbol: APC
APC
0.400 Biomarker disease BEFREE We investigated cell cycle regulators (p53, p21, Rb), APC, beta-catenin and NF-kappaB using immunohistochemistry and EBV using in situ hybridisation for EBV encoded small RNAs in 117 cases of gastric carcinoma. 20025482 2010
Entrez Id: 324
Gene Symbol: APC
APC
0.400 Biomarker disease BEFREE Five different classes of methylation behaviors were found: (1) genes methylated in GC only (GSTP1 and RASSF1A); (2) genes showing low methylation frequency (<12%) in CG, IM, and GA, but significantly higher methylation frequency in GC (COX-2, hMLH1, and p16); (3) a gene with low and similar methylation frequency (8.8-21.3%) in four-step lesions (MGMT); (4) genes with high and similar methylation frequency (53-85%) in four-step lesions (APC and E-cadherin); and (5) genes showing an increasing tendency with or without fluctuation of the methylation frequency along the progression (DAP-kinase, p14, THBS1, and TIMP3). 12746473 2003
Entrez Id: 324
Gene Symbol: APC
APC
0.400 Biomarker disease BEFREE Five different classes of methylation behaviors were found: (a). genes methylated in GC only (GSTP1 and RASSF1A), (b). genes showing low methylation frequency (<12%) in CG, IM, and gastric adenoma (GA) but significantly higher methylation frequency in GC (COX-2, hMLH1, p16), (c). a gene with low and similar methylation frequency (8.8-21.3%) in four-step lesions (MGMT), (d). genes with high and similar methylation frequency (53-85%) in four-step lesions (APC and E-cadherin), and (e). genes showing an increasing tendency with or without fluctuation of the methylation frequency along the progression (DAP-kinase, p14, THBS1, and TIMP-3). 12695555 2003
Entrez Id: 324
Gene Symbol: APC
APC
0.400 AlteredExpression disease BEFREE APC gene expression in gastric carcinoma: an immunohistochemical study. 12373147 2002
Entrez Id: 324
Gene Symbol: APC
APC
0.400 Biomarker disease BEFREE THBS1, APC, p16, 14-3-3 sigma, MINT1, and MINT25 were methylated at a frequency >90% in EBV-positive GCs. 11891177 2002
Entrez Id: 324
Gene Symbol: APC
APC
0.400 GeneticVariation disease BEFREE APC mutation is involved in carcinogenesis of intestinal type of gastric cancer and is independent of MSI phenotype but related to the LOH pathway in gastric cancer. 12378616 2002
Entrez Id: 324
Gene Symbol: APC
APC
0.400 GeneticVariation disease BEFREE Infrequent loss of heterozygosity of APC/MCC and DCC genes in gastric cancer showing DNA microsatellite instability. 10605402 1999
Entrez Id: 324
Gene Symbol: APC
APC
0.400 GeneticVariation disease BEFREE Gastric cancer showed frequent genetic alterations of the APC gene, and the risk for gastric cancer in familial adenomatosus polyposis patients is 10 times higher than that in the general population. 10485468 1999
Entrez Id: 324
Gene Symbol: APC
APC
0.400 Biomarker disease BEFREE These data suggest that allelic deletion of the p53 gene in intestinal-type gastric carcinoma predicts the invasive potential of mucosal cancer, and that inactivation of the APC gene plays a role in the genetic tumorigenesis of both intestinal and diffuse types of gastric cancer. 9990480 1998
Entrez Id: 324
Gene Symbol: APC
APC
0.400 GeneticVariation disease BEFREE Thus, LOH at APC and/or MCC is considered to be one of the most prevalent genetic alterations in human gastric carcinoma and occurs at an early stage of the carcinogenesis. 8226275 1993
Entrez Id: 324
Gene Symbol: APC
APC
0.400 Biomarker disease BEFREE Our results suggest that there are distinct differences in the molecular pathogenesis of gastric and pancreatic cancer and that abnormalities of APC and MCC may be involved particularly in the diffuse type of gastric cancer. 8406987 1993
Entrez Id: 324
Gene Symbol: APC
APC
0.400 GeneticVariation disease BEFREE Since some gastric cancers are considered to originate from the intestinal metaplasia, it is likely that the adenomatous polyposis coli (APC) gene, the mutation of which causes adenomatous polyps in the colon, is associated with carcinogenesis of gastric cancer. 1317264 1992
Entrez Id: 324
Gene Symbol: APC
APC
0.400 CausalMutation disease CGI