Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4582
Gene Symbol: MUC1
MUC1
0.200 Biomarker disease BEFREE The surface marker expression suggested a tumor origin of the cells, and indicated the intestinal phenotype of a GC (CD10<sup>+</sup>, MUC1). 29552124 2018
Entrez Id: 4582
Gene Symbol: MUC1
MUC1
0.200 GeneticVariation disease BEFREE Our study confirms the protective effect of MUC1 rs4072037 polymorphism on the risk of GC under the dominant model. 28489708 2018
Entrez Id: 4582
Gene Symbol: MUC1
MUC1
0.200 GeneticVariation disease BEFREE However, subtype-specific associations were observed for gastric cardia adenocarcinomas at MUC1/TRIM46/1q22 rs2070803 [HRAA versus GA+GG = 2.16; 95% confidence interval (CI) = 1.24-3.78; P = 0.0068] and LTA/TNF/6p21.33 rs1799724 (HRTT+CT versus CC = 1.30; 95% CI = 1.07-1.57; P = 0.0077), and for diffuse-type GC at PSCA/8q24.3 rs2294008 (HRTT versus CT+CC = 1.99; 95% CI = 1.33-2.97; P = 7.8E-04). 29028942 2017
Entrez Id: 4582
Gene Symbol: MUC1
MUC1
0.200 GeneticVariation disease BEFREE In conclusion, this meta-analysis suggested that rs4245739 polymorphism in the MUC1 gene may play a pivotal role in the pathogenesis of GC, especially for white populations. 28561882 2017
Entrez Id: 4582
Gene Symbol: MUC1
MUC1
0.200 GeneticVariation disease GWASCAT Identification of new susceptibility loci for gastric non-cardia adenocarcinoma: pooled results from two Chinese genome-wide association studies. 26701879 2017
Entrez Id: 4582
Gene Symbol: MUC1
MUC1
0.200 GeneticVariation disease BEFREE We also confirmed a previously reported association for rs4072037 in MUC1 with p=6.59×10(-8) for total gastric cancer and similar estimates for cardia and non-cardia cancers. 26129866 2016
Entrez Id: 4582
Gene Symbol: MUC1
MUC1
0.200 GeneticVariation disease GWASCAT Genome-wide association study of gastric adenocarcinoma in Asia: a comparison of associations between cardia and non-cardia tumours. 26129866 2016
Entrez Id: 4582
Gene Symbol: MUC1
MUC1
0.200 GeneticVariation disease BEFREE Those subjects with both the risk alleles MUC1 rs9841504 and ZBTB20 rs4072037 had a greater than 3-fold increased risk of gastric cancer. 27127881 2016
Entrez Id: 4582
Gene Symbol: MUC1
MUC1
0.200 GeneticVariation disease BEFREE In summary, these results suggest that the MUC1 rs4072037G allele may be a low-penetrating protection factor for GCa risk in Chinese populations. 26910281 2016
Entrez Id: 4582
Gene Symbol: MUC1
MUC1
0.200 GeneticVariation disease GWASCAT Loss-of-function variants in ATM confer risk of gastric cancer. 26098866 2015
Entrez Id: 4582
Gene Symbol: MUC1
MUC1
0.200 GeneticVariation disease BEFREE Our results confirm an association between gastric cancer in Europeans and three loci previously reported in Asians, MUC1, PRKAA1 and PSCA, refine the association signal at PRKAA1 and support a pathogenic role for the tandem repeat identified in MUC1. 26098866 2015
Entrez Id: 4582
Gene Symbol: MUC1
MUC1
0.200 GeneticVariation disease BEFREE Associations of genetic variants in the PSCA, MUC1 and PLCE1 genes with stomach cancer susceptibility in a Chinese population. 25658482 2015
Entrez Id: 4582
Gene Symbol: MUC1
MUC1
0.200 GeneticVariation disease BEFREE The aim of this study was to determine whether rs4072037A > G in MUC1 at 1q22 and rs2274223A > G in PLCE1 at 10q23 are associated with a risk of gastric cancer in a Korean population. 24254309 2014
Entrez Id: 4582
Gene Symbol: MUC1
MUC1
0.200 GeneticVariation disease BEFREE Polymorphisms of PSCA (rs2976392, rs2294008) and MUC1 (rs4072037) genes are associated with GC and HRAG. 25503145 2014
Entrez Id: 4582
Gene Symbol: MUC1
MUC1
0.200 GeneticVariation disease BEFREE Recently, genome-wide association studies (GWAS) on Japanese and Chinese populations identified chromosome 1q22 as a GC susceptibility locus which harbors mucin 1 gene (MUC1) encoding a cell membrane-bound mucin protein. 24810688 2014
Entrez Id: 4582
Gene Symbol: MUC1
MUC1
0.200 GeneticVariation disease BEFREE In conclusion, MUC1 rs4072037 polymorphism may be used as potential biomarker for cancer susceptibility particularly for gastric cancer and for Asian population. 24755768 2014
Entrez Id: 4582
Gene Symbol: MUC1
MUC1
0.200 GeneticVariation disease BEFREE Association studies involving MUC1 rs4072037 polymorphism and GC risk were identified up to June 30, 2012. 24072653 2013
Entrez Id: 4582
Gene Symbol: MUC1
MUC1
0.200 GeneticVariation disease BEFREE Overall, our data indicated that common genetic variations in MUC1 gene might not make a major contribution to the risk of H. pylori infection and non-cardia gastric cancer in our studied population. 24460302 2013
Entrez Id: 4582
Gene Symbol: MUC1
MUC1
0.200 GeneticVariation disease BEFREE In this two-stage study, we selected 24 putative functional tag single-nucleotide polymorphisms (tagSNPs) for six H.pylori-related host genes, MUC1, toll-like receptor 4 (TLR4), protein tyrosine phosphatase, non-receptor type 11 (PTPN11), IL-1B, PGC and PGA3-5, and analyzed their influence and interaction with H.pylori on the GA and GC risks. 23455381 2013
Entrez Id: 4582
Gene Symbol: MUC1
MUC1
0.200 Biomarker disease BEFREE From the second candidate locus identified using the GWAS, 1q22, we found the Mucin 1 (MUC1) gene encoding a cell membrane-bound mucin protein as another gene related to diffuse-type GC. 23057512 2013
Entrez Id: 4582
Gene Symbol: MUC1
MUC1
0.200 GeneticVariation disease BEFREE Our study suggested rs2294008 in the PSCA gene to be associated with increased risk of gastric cancer and rs2070803 in MUC1 to play a protective role in a Chinese population. 22938426 2012
Entrez Id: 4582
Gene Symbol: MUC1
MUC1
0.200 GeneticVariation disease BEFREE The rs4072037 polymorphism in MUC1 was associated with a reduced risk of GC of intestinal histological type (OR 0.4; 95% CI 0.2-0.9) and a reduced risk of oesophageal squamous cell cancer (OR 0.5; 95% CI 0.2-1.0), but not oesphageal adenocarcinoma. 22805490 2012
Entrez Id: 4582
Gene Symbol: MUC1
MUC1
0.200 GeneticVariation disease BEFREE The SNPs rs2070803 and rs4072037 in MUC1 might be used to identify individuals at risk for this type of gastric cancer. 21070779 2011
Entrez Id: 4582
Gene Symbol: MUC1
MUC1
0.200 GeneticVariation disease BEFREE Overall, our data provide evidence that some common variations in MUC1 and MUC5AC genes contribute to an elevated risk of stomach cancer. 19924550 2010
Entrez Id: 4582
Gene Symbol: MUC1
MUC1
0.200 GeneticVariation disease GWASCAT A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma. 20729852 2010