Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
0.390 | AlteredExpression | disease | BEFREE | Furthermore, LKB1 expression in GC was inversely associated with p53 (<i>r</i>=-0.181, <i>P</i>=0.027) and survivin expression (<i>r</i>=-0.198, <i>P</i>=0.015). | 30863111 | 2019 | ||||
|
0.390 | AlteredExpression | disease | BEFREE | Results revealed that the expression of LKB1 was decreased in GC tissues compared with that in adjacent paracancerous tissues (P = .005). | 30171989 | 2019 | ||||
|
0.390 | Biomarker | disease | BEFREE | LKB1-AMPK activation in GC cell lines was tumor suppressive, as metformin (an AMPK activator) inhibited GC cell growth in the CAB39L-silenced cells. | 30054562 | 2018 | ||||
|
0.390 | Biomarker | disease | BEFREE | LKB1 protein is a tumor‑suppressor in gastric cancer and may be potentially be developed as a novel gene therapy target in the treatment of gastric cancer. | 26549522 | 2016 | ||||
|
0.390 | AlteredExpression | disease | BEFREE | Multivariate Cox regression analysis indicated that both LKB1 mRNA and protein expression in gastric cancer were independent prognostic factors for OS. | 26976973 | 2016 | ||||
|
0.390 | GeneticVariation | disease | BEFREE | Moreover, we observed a new case of aggressive gastric cancer in a young patient with a frameshift mutation of STK11 gene. | 19615099 | 2009 | ||||
|
0.390 | GeneticVariation | disease | BEFREE | This is the first report of a STK11 germline mutation in a PJS patient with GC and should contribute to establishing correlations between the STK11 germline mutations and GC in PJS patients. | 15617552 | 2005 | ||||
|
0.390 | GeneticVariation | disease | BEFREE | We found a novel germline frameshift mutation (757-758insT) in the LKB1 gene and a marked reduction in LKB1 protein expression in the carcinoma cells, suggesting that the loss of LKB1 function may have led to the carcinogenesis of the gastric cancer. | 15622488 | 2004 | ||||
|
0.390 | GeneticVariation | disease | BEFREE | Mutations of the STK11 gene in sporadic gastric carcinoma. | 9683800 | 1998 | ||||
|
0.390 | GeneticVariation | disease | UNIPROT |