Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6794
Gene Symbol: STK11
STK11
0.390 AlteredExpression disease BEFREE Furthermore, LKB1 expression in GC was inversely associated with p53 (<i>r</i>=-0.181, <i>P</i>=0.027) and survivin expression (<i>r</i>=-0.198, <i>P</i>=0.015). 30863111 2019
Entrez Id: 6794
Gene Symbol: STK11
STK11
0.390 AlteredExpression disease BEFREE Results revealed that the expression of LKB1 was decreased in GC tissues compared with that in adjacent paracancerous tissues (P = .005). 30171989 2019
Entrez Id: 6794
Gene Symbol: STK11
STK11
0.390 Biomarker disease BEFREE LKB1-AMPK activation in GC cell lines was tumor suppressive, as metformin (an AMPK activator) inhibited GC cell growth in the CAB39L-silenced cells. 30054562 2018
Entrez Id: 6794
Gene Symbol: STK11
STK11
0.390 Biomarker disease BEFREE LKB1 protein is a tumor‑suppressor in gastric cancer and may be potentially be developed as a novel gene therapy target in the treatment of gastric cancer. 26549522 2016
Entrez Id: 6794
Gene Symbol: STK11
STK11
0.390 AlteredExpression disease BEFREE Multivariate Cox regression analysis indicated that both LKB1 mRNA and protein expression in gastric cancer were independent prognostic factors for OS. 26976973 2016
Entrez Id: 6794
Gene Symbol: STK11
STK11
0.390 GeneticVariation disease BEFREE Moreover, we observed a new case of aggressive gastric cancer in a young patient with a frameshift mutation of STK11 gene. 19615099 2009
Entrez Id: 6794
Gene Symbol: STK11
STK11
0.390 GeneticVariation disease BEFREE This is the first report of a STK11 germline mutation in a PJS patient with GC and should contribute to establishing correlations between the STK11 germline mutations and GC in PJS patients. 15617552 2005
Entrez Id: 6794
Gene Symbol: STK11
STK11
0.390 GeneticVariation disease BEFREE We found a novel germline frameshift mutation (757-758insT) in the LKB1 gene and a marked reduction in LKB1 protein expression in the carcinoma cells, suggesting that the loss of LKB1 function may have led to the carcinogenesis of the gastric cancer. 15622488 2004
Entrez Id: 6794
Gene Symbol: STK11
STK11
0.390 GeneticVariation disease BEFREE Mutations of the STK11 gene in sporadic gastric carcinoma. 9683800 1998
Entrez Id: 6794
Gene Symbol: STK11
STK11
0.390 GeneticVariation disease UNIPROT