| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.370 | Biomarker | disease | BEFREE | Mechanism investigations revealed that NOTCH1 is a target of miR-34c-5p in BCa. | 30426533 | 2019 | ||||
|
0.370 | Biomarker | disease | BEFREE | Studies indicating that NOTCH1 and NOTCH2 have opposite effects on the progression of bladder cancer could give rise to potential therapeutic approaches aimed at blocking or restoring the Notch pathway. | 29643502 | 2018 | ||||
|
0.370 | Biomarker | disease | BEFREE | In this study, we show that non-cytotoxic nanomolar DAC concentrations modify the bladder cancer transcriptome to activate NOTCH1 at the mRNA and protein level, increase double-stranded RNA sensors and CK5-dependent differentiation. | 29242529 | 2017 | ||||
|
0.370 | Biomarker | disease | BEFREE | NOTCH has been identified as a tumor suppressor in bladder cancer, but prior reports have focused on NOTCH1 Here we hypothesized that NOTCH2 is an oncogene suitable for therapeutic targeting in bladder cancer. | 26769750 | 2016 | ||||
|
0.370 | AlteredExpression | disease | BEFREE | A previous study by our group demonstrated that the expression levels of Notch 1 and Jagged 1 in bladder cancer cells was significantly lower compared with those in normal bladder mucosa, while the expression levels of Notch 1 and Jagged 1 in invasive bladder cancer were higher compared with those in superficial bladder cancer. | 25955824 | 2015 | ||||
|
0.370 | Biomarker | disease | BEFREE | PsiRNA1‑mediated Notch-1 and KLF4 knockdown models and control model without the psiRNA1 vector were constructed using bladder cancer cell lines T24 and BIU87. | 25109409 | 2014 | ||||
|
0.370 | AlteredExpression | disease | BEFREE | This study aimed at an evaluation of Oct-4 and Notch-1 expression in both carcinoma and stromal cells of 83 cases of primary bladder carcinoma and to study the relationship between them. | 23594289 | 2013 | ||||
|
0.370 | CausalMutation | disease | CGI |