Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 841
Gene Symbol: CASP8
CASP8
0.100 Biomarker disease BEFREE Caspase 8-null neuroblastoma cells were resistant to death receptor- and doxorubicin-mediated apoptosis, deficits that were corrected by programmed expression of the enzyme. 10802708 2000
Entrez Id: 841
Gene Symbol: CASP8
CASP8
0.100 Biomarker disease BEFREE Caspase-8 silenced N-type invasive NB cell lines LAN-1 and IMR-32 were investigated for their sensitivity to dox, and compared to S-type noninvasive SH-EP NB cells expressing caspase-8. 12203125 2002
Entrez Id: 841
Gene Symbol: CASP8
CASP8
0.100 Biomarker disease BEFREE CASP8 defects therefore represent an independent event in neuroblastoma, counteracting the N-myc induced susceptibility to apoptosis. 12880977 2003
Entrez Id: 841
Gene Symbol: CASP8
CASP8
0.100 AlteredExpression disease BEFREE Caspase-8 levels correlate with the expression of signal transducer and activator of transcription 1 in high-grade but not lower grade neuroblastoma. 16886176 2006
Entrez Id: 841
Gene Symbol: CASP8
CASP8
0.100 AlteredExpression disease BEFREE A missense mutation was detected at codon 96, GCT (Alanine) to GTT (Valine), of the caspase 8 gene in one of the NB cell lines lacking caspase 8 expression. 11466626 2001
Entrez Id: 841
Gene Symbol: CASP8
CASP8
0.100 GeneticVariation disease BEFREE A missense SNP in exon 10 of the CASP8 gene SNP D302H was associated with worse overall and event-free survival in patients with MYCN-amplified neuroblastoma tumors. 25502557 2014
Entrez Id: 841
Gene Symbol: CASP8
CASP8
0.100 AlteredExpression disease BEFREE An interferon-sensitive response element is involved in constitutive caspase-8 gene expression in neuroblastoma cells. 17036321 2007
Entrez Id: 841
Gene Symbol: CASP8
CASP8
0.100 PosttranslationalModification disease BEFREE As frequent methylation of the CASP8 gene has also been reported in neuroblastoma, we investigated whether RASSF1A and CASP8 methylation were independent or related events. 11709729 2001
Entrez Id: 841
Gene Symbol: CASP8
CASP8
0.100 AlteredExpression disease BEFREE By revealing no correlation between caspase-8 expression and MYCN amplification or other established variables of aggressive disease, our findings in a large cohort of neuroblastoma patients show that inactivation of caspase-8 is not a characteristic feature of aggressive neuroblastoma. 17047064 2006
Entrez Id: 841
Gene Symbol: CASP8
CASP8
0.100 GeneticVariation disease BEFREE Contrarily, the presence of the -652 6N Del or the CASP8 302His variant was reported to be an unfavorable prognostic factor in colorectal cancer or neuroblastoma. 27507139 2016
Entrez Id: 841
Gene Symbol: CASP8
CASP8
0.100 PosttranslationalModification disease BEFREE Detection of CpG island hypermethylation of caspase-8 in neuroblastoma using an oligonucleotide array. 19260109 2009
Entrez Id: 841
Gene Symbol: CASP8
CASP8
0.100 PosttranslationalModification disease BEFREE Epigenetic alterations have been described as well: caspase-8 (CASP8) and RAS-association domain family 1 isoform A (RASSF1A) DNA-methylation are important events for the development and progression of neuroblastoma. 21725203 2011
Entrez Id: 841
Gene Symbol: CASP8
CASP8
0.100 AlteredExpression disease BEFREE Exogenous interferon-γ upregulated expression of caspase-8 in 3 of 4 neuroblastoma cell lines and increased the contribution of TRAIL to NK cytotoxicity against 2 of the 3 lines; however, relatively little inhibition of cytotoxicity was observed when activated NK cells were treated with an anti-interferon-γ neutralizing antibody. 23719242 2013
Entrez Id: 841
Gene Symbol: CASP8
CASP8
0.100 PosttranslationalModification disease BEFREE Frequent promoter hypermethylation of RASSF1A and CASP8 in neuroblastoma. 17064406 2006
Entrez Id: 841
Gene Symbol: CASP8
CASP8
0.100 Biomarker disease BEFREE Furthermore, gemcitabine-induced apoptosis was observed irrespective of the caspase-8 status of neuroblastoma cells, which indicates that apoptosis depends on the mitochondrial pathway. 15867251 2005
Entrez Id: 841
Gene Symbol: CASP8
CASP8
0.100 Biomarker disease BEFREE Furthermore, the methylation pattern of 14.3.3sigma, RASSF1A and of an intragenic segment of CASP8 was significantly different between MYCN amplified and single copy neuroblastoma suggesting a specific role of epigenetic alterations in aggressive neuroblastoma. 16044164 2005
Entrez Id: 841
Gene Symbol: CASP8
CASP8
0.100 AlteredExpression disease BEFREE Here we show that four different retinoic acid (RA) derivatives also increase caspase-8 protein expression in neuroblastoma, medulloblastoma and small cell lung carcinoma cell lines. 18342014 2008
Entrez Id: 841
Gene Symbol: CASP8
CASP8
0.100 PosttranslationalModification disease BEFREE However, approximately 20% of the neuroblastoma cell lines with methylated CASP8 alleles are also highly resistant to staurosporine (STS)- and radiation-induced cell death, presumably because cytochrome c is not released from mitochondria. 11896617 2002
Entrez Id: 841
Gene Symbol: CASP8
CASP8
0.100 Biomarker disease BEFREE However, the IFN-gamma restoration of caspase 8 in some NB cells revealed persistent TRAIL resistance in most NB cell lines examined. 12615731 2003
Entrez Id: 841
Gene Symbol: CASP8
CASP8
0.100 AlteredExpression disease BEFREE Our results show that restoration of active caspase-8 expression in a caspase-8-deficient NB cell line is necessary and sufficient to fully restore TRAIL sensitivity. 15094781 2004
Entrez Id: 841
Gene Symbol: CASP8
CASP8
0.100 AlteredExpression disease BEFREE Re-expression of caspase-8 in neuroblastoma cells lacking endogenous caspase-8 expression was found to promote cell adhesion to extracellular matrix and to activate adhesion-dependent signaling pathways, such as the Erk kinase cascade. 18089800 2007
Entrez Id: 841
Gene Symbol: CASP8
CASP8
0.100 Biomarker disease BEFREE Restoration of TRAIL-induced apoptosis in a caspase-8-deficient neuroblastoma cell line by stable re-expression of caspase-8. 15033719 2003
Entrez Id: 841
Gene Symbol: CASP8
CASP8
0.100 PosttranslationalModification disease BEFREE Sixty-two NBs (45 primary tumors and 17 NBs at relapse) were studied in terms of the methylation status of 19 genes (p15INK4a, p16INK4a, p14ARF, APC, RB1, RASSF1A, BLU, FHIT, RARbeta, INI1, TIMP3, NF2, MGMT, DAPK, FLIP, ECAD, CASP8, and the receptors DcR1 and DcR2). 17570703 2008
Entrez Id: 841
Gene Symbol: CASP8
CASP8
0.100 AlteredExpression disease BEFREE Subcellular fractionation analysis revealed caspase-8 activity in both cytosol and plasma membrane fractions in both NB7 reconstituted caspase-8 cell lines, as well the LNCaP prostate cancer cells. 23456622 2013
Entrez Id: 841
Gene Symbol: CASP8
CASP8
0.100 PosttranslationalModification disease BEFREE Subsequently others have also shown that caspase-8 is silenced by methylation in neuroblastoma and peripheral neural ectodermal tumors, and that the caspase-9 regulator Apaf-1 is silenced by methylation in melanoma cell lines and patient samples. 11511973 2001