Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 841
Gene Symbol: CASP8
CASP8
0.100 AlteredExpression disease BEFREE We established N-myc-downregulated IMR-32 cells using shRNA lentiviral particles targeting N-myc and examined the effect the N-myc inhibition on TRAIL susceptibility in human neuroblastoma IMR-32 cells expressing caspase-8. 30724400 2019
Entrez Id: 841
Gene Symbol: CASP8
CASP8
0.100 GeneticVariation disease BEFREE Contrarily, the presence of the -652 6N Del or the CASP8 302His variant was reported to be an unfavorable prognostic factor in colorectal cancer or neuroblastoma. 27507139 2016
Entrez Id: 841
Gene Symbol: CASP8
CASP8
0.100 GeneticVariation disease BEFREE A missense SNP in exon 10 of the CASP8 gene SNP D302H was associated with worse overall and event-free survival in patients with MYCN-amplified neuroblastoma tumors. 25502557 2014
Entrez Id: 841
Gene Symbol: CASP8
CASP8
0.100 AlteredExpression disease BEFREE Subcellular fractionation analysis revealed caspase-8 activity in both cytosol and plasma membrane fractions in both NB7 reconstituted caspase-8 cell lines, as well the LNCaP prostate cancer cells. 23456622 2013
Entrez Id: 841
Gene Symbol: CASP8
CASP8
0.100 AlteredExpression disease BEFREE Exogenous interferon-γ upregulated expression of caspase-8 in 3 of 4 neuroblastoma cell lines and increased the contribution of TRAIL to NK cytotoxicity against 2 of the 3 lines; however, relatively little inhibition of cytotoxicity was observed when activated NK cells were treated with an anti-interferon-γ neutralizing antibody. 23719242 2013
Entrez Id: 841
Gene Symbol: CASP8
CASP8
0.100 AlteredExpression disease BEFREE The combined data suggest that FOXO3 is activated by 5-azadC treatment and triggers expression of caspase-8 in caspase-8-negative neuroblastoma, which may have important implication for metastasis, therapy, and death resistance of this childhood malignancy. 22493319 2012
Entrez Id: 841
Gene Symbol: CASP8
CASP8
0.100 PosttranslationalModification disease BEFREE Epigenetic alterations have been described as well: caspase-8 (CASP8) and RAS-association domain family 1 isoform A (RASSF1A) DNA-methylation are important events for the development and progression of neuroblastoma. 21725203 2011
Entrez Id: 841
Gene Symbol: CASP8
CASP8
0.100 Biomarker disease BEFREE We propose the simultaneous analysis of hypermethylation of APAF1, TMS1 and CASP8 apoptotic genes on primary NB tumour as a good prognostic factor of disease progression. 21104989 2011
Entrez Id: 841
Gene Symbol: CASP8
CASP8
0.100 AlteredExpression disease BEFREE The relative caspase 8 activity of NB cells expressing caspase 8 increased with the prolongation of TRAIL action time. 19954364 2009
Entrez Id: 841
Gene Symbol: CASP8
CASP8
0.100 PosttranslationalModification disease BEFREE Detection of CpG island hypermethylation of caspase-8 in neuroblastoma using an oligonucleotide array. 19260109 2009
Entrez Id: 841
Gene Symbol: CASP8
CASP8
0.100 AlteredExpression disease BEFREE Here we show that four different retinoic acid (RA) derivatives also increase caspase-8 protein expression in neuroblastoma, medulloblastoma and small cell lung carcinoma cell lines. 18342014 2008
Entrez Id: 841
Gene Symbol: CASP8
CASP8
0.100 AlteredExpression disease BEFREE These data indicate that the pattern of expression of these neural-enriched IG20-SVs regulates the expression and activation of caspase-8 in certain neuroblastoma cells, and that manipulation of IG20-SV expression pattern may represent a potent therapeutic strategy in the therapy of neuroblastoma and perhaps other cancers. 18794122 2008
Entrez Id: 841
Gene Symbol: CASP8
CASP8
0.100 PosttranslationalModification disease BEFREE Sixty-two NBs (45 primary tumors and 17 NBs at relapse) were studied in terms of the methylation status of 19 genes (p15INK4a, p16INK4a, p14ARF, APC, RB1, RASSF1A, BLU, FHIT, RARbeta, INI1, TIMP3, NF2, MGMT, DAPK, FLIP, ECAD, CASP8, and the receptors DcR1 and DcR2). 17570703 2008
Entrez Id: 841
Gene Symbol: CASP8
CASP8
0.100 AlteredExpression disease BEFREE Re-expression of caspase-8 in neuroblastoma cells lacking endogenous caspase-8 expression was found to promote cell adhesion to extracellular matrix and to activate adhesion-dependent signaling pathways, such as the Erk kinase cascade. 18089800 2007
Entrez Id: 841
Gene Symbol: CASP8
CASP8
0.100 AlteredExpression disease BEFREE An interferon-sensitive response element is involved in constitutive caspase-8 gene expression in neuroblastoma cells. 17036321 2007
Entrez Id: 841
Gene Symbol: CASP8
CASP8
0.100 PosttranslationalModification disease BEFREE Frequent promoter hypermethylation of RASSF1A and CASP8 in neuroblastoma. 17064406 2006
Entrez Id: 841
Gene Symbol: CASP8
CASP8
0.100 AlteredExpression disease BEFREE Caspase-8 levels correlate with the expression of signal transducer and activator of transcription 1 in high-grade but not lower grade neuroblastoma. 16886176 2006
Entrez Id: 841
Gene Symbol: CASP8
CASP8
0.100 Biomarker disease BEFREE These findings define caspase-8 as a metastasis suppressor gene that, together with integrins, regulates the survival and invasive capacity of neuroblastoma cells. 16397500 2006
Entrez Id: 841
Gene Symbol: CASP8
CASP8
0.100 AlteredExpression disease BEFREE We investigated whether the levels of survivin and caspase 8 and the ratio between these 2 apoptotic factors correlate with tumor biology and predicts outcome in patients with neuroblastoma. 16825985 2006
Entrez Id: 841
Gene Symbol: CASP8
CASP8
0.100 AlteredExpression disease BEFREE We sought to determine whether caspase 8l is present in neuroblastoma and whether over-expression of this protein could inhibit caspase 8-dependent apoptosis. 16374545 2006
Entrez Id: 841
Gene Symbol: CASP8
CASP8
0.100 AlteredExpression disease BEFREE Thus, by demonstrating that 5-dAzaC and IFN-gamma at relatively low individual concentrations cooperate to restore caspase-8 expression and sensitize resistant neuroblastoma and medulloblastoma cells to TRAIL-induced apoptosis, our findings have important implications for novel strategies targeting defective apoptosis pathways in neuroectodermal tumors. 16607283 2006
Entrez Id: 841
Gene Symbol: CASP8
CASP8
0.100 AlteredExpression disease BEFREE By revealing no correlation between caspase-8 expression and MYCN amplification or other established variables of aggressive disease, our findings in a large cohort of neuroblastoma patients show that inactivation of caspase-8 is not a characteristic feature of aggressive neuroblastoma. 17047064 2006
Entrez Id: 841
Gene Symbol: CASP8
CASP8
0.100 Biomarker disease BEFREE Furthermore, the methylation pattern of 14.3.3sigma, RASSF1A and of an intragenic segment of CASP8 was significantly different between MYCN amplified and single copy neuroblastoma suggesting a specific role of epigenetic alterations in aggressive neuroblastoma. 16044164 2005
Entrez Id: 841
Gene Symbol: CASP8
CASP8
0.100 Biomarker disease BEFREE Furthermore, gemcitabine-induced apoptosis was observed irrespective of the caspase-8 status of neuroblastoma cells, which indicates that apoptosis depends on the mitochondrial pathway. 15867251 2005
Entrez Id: 841
Gene Symbol: CASP8
CASP8
0.100 AlteredExpression disease BEFREE Our results show that restoration of active caspase-8 expression in a caspase-8-deficient NB cell line is necessary and sufficient to fully restore TRAIL sensitivity. 15094781 2004