Here, we fabricated the polysulfone microtube array membranes (PSF MTAM) to encapsulate probiotic <i>S.</i><i>epidermidis.</i> We demonstrate that the application of the encapsulation of <i>S.</i><i>epidermidis</i> in PSF MTAM enhanced the glycerol fermentation activities of <i>S. epidermidis.</i> To mimic the granulomatous type of acne inflammatory acne vulgaris, the ears of mice were injected intradermally with <i>C</i><i>.</i><i>acnes</i> to induce the secretion of macrophage inflammatory protein-2 (MIP-2), a murine counterpart of human interleukin (IL)-8.