In this review, we discuss the most recent lines of evidence on the main metabolic factors that are known to be associated with CHC, namely, insulin resistance/type 2 diabetes, steatosis, visceral obesity, atherosclerosis, vitamin D, menopause, fructose and coffee intake, lipoproteins, methylenetetrahydrofolate reductase status, and hyperuricaemia.
Although the mechanism of the relationship between the C677T polymorphism and uric acid still remains unclear, these original articles showed that the MTHFRC677T polymorphism may be an independent risk factor for hyperuricemia.
There was no clear difference in SUA means among those with different genotypes of MTHFR and TS, but a significant association between hyperuricemia (SUA > or =7mg/dL) and MTHFR 677T allele carriers was observed.
Results from this study suggest that mutation of 5-MTHFRC677T contributes to the higher uric acid levels in both males and females and may be a risk factor for hyperuricemia.
Results from this study suggest that mutation of 5-MTHFRC677T contributes to the higher uric acid levels in both males and females and may be a risk factor for hyperuricemia.