Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7498
Gene Symbol: XDH
XDH
0.600 Biomarker disease BEFREE Topiroxostat is a selective xanthine oxidoreductase (XOR) inhibitor for the management of hyperuricemia in patients with or without gout. 31733581 2020
Entrez Id: 7498
Gene Symbol: XDH
XDH
0.600 AlteredExpression disease BEFREE Plasma XOR activity has been shown to be associated with obesity, smoking, liver dysfunction, hyperuricemia, dyslipidemia and insulin resistance. 30516339 2019
Entrez Id: 7498
Gene Symbol: XDH
XDH
0.600 AlteredExpression disease BEFREE These data demonstrate that hepatocyte XOR activity is a critical determinant of systemic UA homeostasis, that deletion of hepatocyte <i>Xdh</i> is sufficient to prevent systemic HyUA of obesity, and that neither prevention nor correction of HyUA improves insulin resistance/dyslipidemia in obesity. 30936145 2019
Entrez Id: 7498
Gene Symbol: XDH
XDH
0.600 AlteredExpression disease BEFREE Xanthine oxidase (XO) is a form of xanthine oxidoreductase, a type of enzyme that plays a key role in the induction of hyperuricemia and raising superoxide radical level in blood. 31639647 2019
Entrez Id: 7498
Gene Symbol: XDH
XDH
0.600 Biomarker disease BEFREE Despite the availability of different drugs to inhibit in vivo XOR activity, the complexity of XOR inhibition effects should be carefully considered before clinical application, save in the case of symptomatic hyperuricemia. 30576922 2019
Entrez Id: 7498
Gene Symbol: XDH
XDH
0.600 Biomarker disease CTD_human Potential cow milk xanthine oxidase inhibitory and antioxidant activity of selected phenolic acid derivatives. 29071757 2018
Entrez Id: 7498
Gene Symbol: XDH
XDH
0.600 Biomarker disease BEFREE Human Xanthine oxidoreductase (HsXOR) is considered to be a pharmacological target for the treatment of hyperuricemia. 29906649 2018
Entrez Id: 7498
Gene Symbol: XDH
XDH
0.600 Biomarker disease BEFREE The Excited-UA study would provide novel evidence for the clinical relevancy of xanthine oxidoreductase inhibitor treatment in patients with chronic heart failure and hyperuricemia. 29916098 2018
Entrez Id: 7498
Gene Symbol: XDH
XDH
0.600 Biomarker disease BEFREE We attempted to examine the uric acid-lowering effect and the renoprotective effect of topiroxostat, a selective xanthine oxidoreductase inhibitor, in patients with diabetic nephropathy and hyperuricemia in this pilot study. 29372470 2018
Entrez Id: 7498
Gene Symbol: XDH
XDH
0.600 AlteredExpression disease BEFREE ALLO can significantly decrease serum uric acid levels (P<0.01) and raise XDH/XO mRNA expression levels in the liver tissue of tree shrews with HUA. 28302963 2017
Entrez Id: 7498
Gene Symbol: XDH
XDH
0.600 Biomarker disease BEFREE CONCLUSIONS GPS may be an effective treatment for hyperuricemia via a decrease in xanthine oxidoreductase through the XOD/XDH system; and via an increase in urate excretion through regulating URAT1, GLUT9, and OAT1 transporters. 28258276 2017
Entrez Id: 7498
Gene Symbol: XDH
XDH
0.600 Biomarker disease BEFREE Moreover, 50 mg/kg/d baicalein treatment significantly suppressed the viability of xanthine oxidoreductase in hyperuricemia mouse model. 28445133 2017
Entrez Id: 7498
Gene Symbol: XDH
XDH
0.600 Biomarker disease BEFREE In addition, the therapeutics currently approved for the treatments of hyperuricemia are outlined and an overview regarding novel, currently researched XOR inhibitors is provided. 28413972 2017
Entrez Id: 7498
Gene Symbol: XDH
XDH
0.600 Therapeutic disease RGD Cd exposure induced hyperuricemia with renal XOR hyperactivity and UA excretion dysfunction in rats. 22690247 2012
Entrez Id: 56606
Gene Symbol: SLC2A9
SLC2A9
0.500 Biomarker disease BEFREE Furthermore, phloretin partly inhibited renal glucose transporter 9 (GLUT9) and promoted urinary UA excretion in HUA mice. 31790902 2020
Entrez Id: 9429
Gene Symbol: ABCG2
ABCG2
0.500 GeneticVariation disease BEFREE In this study, we analyzed the ABCG2 gene in a hyperuricemia and gout cohort focusing on patients with pediatric-onset, i.e., before 18 years of age. 30894219 2019
Entrez Id: 56606
Gene Symbol: SLC2A9
SLC2A9
0.500 Biomarker disease BEFREE In hyperuricemic rats, high EU (400 mg/kg) significantly reduced SUA levels to 253.85 μmol/L, and increased OAT1 and OAT3 levels, but decreased URAT1 and GLUT9, compared to the hyperuricaemia group (p < 0.05). 30843748 2019
Entrez Id: 9429
Gene Symbol: ABCG2
ABCG2
0.500 Biomarker disease BEFREE This essentially includes our recent findings, as we serendipitously identified febuxostat, a well-used agent for hyperuricemia as a strong ABCG2 inhibitor, that possesses some promising potentials. 30890942 2019
Entrez Id: 56606
Gene Symbol: SLC2A9
SLC2A9
0.500 GeneticVariation disease BEFREE Type 2 renal hyperuricemia (RHUC2) is caused by a mutation in the SLC2A9 gene, which encodes a high‑capacity glucose and urate transporter, glucose transporter (GLUT)9. 31638209 2019
Entrez Id: 56606
Gene Symbol: SLC2A9
SLC2A9
0.500 GeneticVariation disease BEFREE For rare variants, six single nucleotide variations (SNVs) p.T21I and p.G13D in SLC2A9, p.W50fs, p.Q382L, p.V547L and p.E458K in SLC22A12, occurred in totally six hypouricemia subjects and were absent in HUA and normal controls. 31131560 2019
Entrez Id: 56606
Gene Symbol: SLC2A9
SLC2A9
0.500 Biomarker disease BEFREE CLA ameliorates hyperuricemia along with insulin resistance and renal inflammatory, which may be associated with the suppression of renal GLUT9 and URAT1 in fructose-fed rats. 30913372 2019
Entrez Id: 9429
Gene Symbol: ABCG2
ABCG2
0.500 Biomarker disease BEFREE Accumulating evidence demonstrates that congenital dysfunction of ABCG2 is an important genetic risk factor in gout and hyperuricemia; recent studies suggest the clinical significance of both common and rare variants of ABCG2. 31003562 2019
Entrez Id: 56606
Gene Symbol: SLC2A9
SLC2A9
0.500 GeneticVariation disease BEFREE In turn, some of these single nucleotide polymorphisms in SLC2A9 may increase the risk of hyperuricemia. 31016517 2019
Entrez Id: 9429
Gene Symbol: ABCG2
ABCG2
0.500 Biomarker disease BEFREE We concluded that ABCG2 gene contributed to hyperuricemia but also gout, and that it was involved in the inflammation dysregulation via augmented IL-8 release in EC. 29453348 2018
Entrez Id: 56606
Gene Symbol: SLC2A9
SLC2A9
0.500 Biomarker disease BEFREE Research on the pharmacodynamics and mechanism of Fraxini Cortex on hyperuricemia based on the regulation of URAT1 and GLUT9. 29990831 2018