| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.090 | Biomarker | disease | BEFREE | Long noncoding RNA EGFR-AS1 promotes cell growth and metastasis via affecting HuR mediated mRNA stability of EGFR in renal cancer. | 30770799 | 2019 | ||||
|
0.090 | Biomarker | disease | BEFREE | Real-time PCR, immunohistochemistry and Western blotting analysis were used to determine CAV2, epidermal growth factor receptor (EGFR), phosphatidylinositol 3-kinase (PI3K) and protein kinase B (Akt) in kidney cancer cell line OS-RC-2 and clinical specimens. | 30288056 | 2018 | ||||
|
0.090 | Biomarker | disease | BEFREE | S100A8 and EGFR are potential therapeutic biomarkers and anticancer drug targets for KC. | 25789858 | 2015 | ||||
|
0.090 | Biomarker | disease | BEFREE | We discuss preclinical data providing rationale for the combination of MET and EGFR inhibitors and review recently completed and ongoing clinical trials that attempt to expand our therapeutic options for this important subset of kidney cancer. | 24629521 | 2014 | ||||
|
0.090 | Biomarker | disease | BEFREE | There are opposite evidences of the role of EGFR in renal cancer and the outcome of EGFR-targeted therapies, suggesting the complexity of EGFR signaling pathways. | 22855173 | 2013 | ||||
|
0.090 | GeneticVariation | disease | BEFREE | Clear-cell renal cell carcinoma (RCC) is the most prevalent form of kidney cancer and is frequently associated with loss of von Hippel-Lindau (VHL) gene function, resulting in the aberrant transcriptional activation of genes that contribute to tumor growth and metastasis, including transforming growth factor-alpha (TGF-alpha), a ligand of the epidermal growth factor receptor (EGFR) tyrosine kinase. | 18243508 | 2008 | ||||
|
0.090 | Biomarker | disease | BEFREE | Silencing of epidermal growth factor receptor suppresses hypoxia-inducible factor-2-driven VHL-/- renal cancer. | 15958567 | 2005 | ||||
|
0.090 | AlteredExpression | disease | BEFREE | Aberrant expression of epidermal growth factor receptor and HER-2 (erbB-2) messenger RNAs in human renal cancers. | 2572319 | 1989 | ||||
|
0.090 | Biomarker | disease | BEFREE | Enhanced expression of c-myc and epidermal growth factor receptor (C-erbB-1) genes in primary human renal cancer. | 2460228 | 1988 |