| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | GeneticVariation | phenotype | BEFREE | <b>Results</b> We found that the early pregnancy loss (EPL) rate increased as MTHFR polymorphism complexity increased and that the early EPL rate was significantly higher in patients with MTHFR C677T polymorphism compared to patients with MTHFR A1298C polymorphism (p = 0.039). | 30258247 | 2018 | ||||
|
0.080 | GeneticVariation | phenotype | BEFREE | MTHFR C677T polymorphism and recurrent early pregnancy loss risk in north Indian population. | 22138544 | 2012 | ||||
|
0.080 | Biomarker | phenotype | BEFREE | Because of the involvement of MTHFR, MTR and MTRR genes with folate metabolism and the evidence that maternal use of folic acid in early pregnancy reduces the risk for CL/P, we evaluated the influence of their polymorphisms on the etiology of CL/P through a case-control study. | 17581676 | 2007 | ||||
|
0.080 | GeneticVariation | phenotype | BEFREE | The methylenetetrahydrofolate reductase (MTHFR) gene C677T and A1298C polymorphisms are commonly associated with defects in folate dependent homocysteine metabolism and have been implicated as risk factors for recurrent embryo loss in early pregnancy. | 11938441 | 2002 | ||||
|
0.080 | GeneticVariation | phenotype | BEFREE | Plasma Hcy concentration during early pregnancy was higher in women with homozygote for the T677 allele in the MTHFR gene than other genotypes. | 11794822 | 2001 | ||||
|
0.080 | GeneticVariation | phenotype | BEFREE | With the present study we can show for the first time that the embryonal MTHFR 677TT genotype is significantly associated with the development of structural congenital heart malformations during early pregnancy. | 11470464 | 2001 | ||||
|
0.080 | GeneticVariation | phenotype | BEFREE | Methylenetetrahydrofolate reductase (MTHFR) mutations are commonly associated with hyperhomocysteinemia, and, through their defects in homocysteine metabolism, they have been implicated as risk factors for neural tube defects and unexplained, recurrent embryo losses in early pregnancy. | 10958762 | 2000 | ||||
|
0.080 | GeneticVariation | phenotype | BEFREE | Because of MTHFR's involvement with folate metabolism and evidence that maternal use of a multivitamin with folic acid in early pregnancy reduces risk for cleft lip with or without cleft palate (CLP), we hypothesized that infants homozygous for the C677T genotype would be at increased risk for CLP because of lower MTHFR enzymatic activity. | 9843036 | 1998 |