Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 GeneticVariation disease BEFREE Apolipoprotein E genotype and concomitant clinical features in early-onset Alzheimer's disease. 8803820 1996
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 Biomarker disease CTD_human Association Analysis of Polymorphisms in TOMM40, CR1, PVRL2, SORL1, PICALM, and 14q32.13 Regions in Colombian Alzheimer Disease Patients. 27023435 2017
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 SusceptibilityMutation disease CLINVAR Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E ϵ4,and the risk of late-onset Alzheimer disease in African Americans. 23571587 2013
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 GeneticVariation disease BEFREE We have found a significantly lower frequency of the presenilin-1 (PS-1) intronic polymorphism 2/2 genotype in early-onset Alzheimer's disease (AD) patients without APOE epsilon4 alleles (2/2 = 0.054; P = 0.009) as compared to age matched non-epsilon4 controls (2/2 = 0.227). 9185685 1997
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 Biomarker disease BEFREE Our study demonstrates a significant association between APOE*4 and EOAD which is modified by family history of dementia. 8075646 1994
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 Biomarker disease BEFREE apolipoprotein-E dependent role for the FAS receptor in early onset Alzheimer's disease: finding of a positive association for a polymorphism in the TNFRSF6 gene. 11129341 2000
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 GeneticVariation disease BEFREE Inverse effect of the APOE epsilon4 allele in late- and early-onset Alzheimer's disease. 26714935 2016
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 SusceptibilityMutation disease CLINVAR Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy. 23296339 2013
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 GeneticVariation disease BEFREE The ApoE4 allele frequency was significantly increased in the patients with eoAD and in those with FTLD. 19091059 2008
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 Biomarker disease CTD_human Hidden heterogeneity in Alzheimer's disease: Insights from genetic association studies and other analyses. 29107063 2018
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 SusceptibilityMutation disease CLINVAR Dominant negative effects of apolipoprotein E4 revealed in transgenic models of neurodegenerative disease. 10799751 2000
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 SusceptibilityMutation disease CLINVAR Longitudinal modeling of age-related memory decline and the APOE epsilon4 effect. 19605830 2009
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 GeneticVariation disease BEFREE In our population, there was no evidence for a protective effect of the APOE*2 allele on the risk of EOAD. 7755355 1995
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 Biomarker disease CTD_human Genome-Wide Association and Mechanistic Studies Indicate That Immune Response Contributes to Alzheimer's Disease Development. 30319691 2018
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 Biomarker disease CTD_human Quantitative Genetics Validates Previous Genetic Variants and Identifies Novel Genetic Players Influencing Alzheimer's Disease Cerebrospinal Fluid Biomarkers. 30320580 2018
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 GeneticVariation disease BEFREE We conclude, contrary to some previous reports, that the ApoE epsilon2 allele does not increase the risk of early-onset sporadic AD. 9307262 1997
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 Biomarker disease CTD_human Elevated serum pesticide levels and risk for Alzheimer disease. 24473795 2014
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 GeneticVariation disease BEFREE Apolipoprotein E genotype and neuropathological phenotype in two members of a German family with chromosome 14-linked early onset Alzheimer's disease. 8525799 1995
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 GeneticVariation disease BEFREE The results of this study suggest that education and female gender, not APOE genotype, may be important as independent strong predictive factors for disease progression in patients with EOAD. 26444786 2016
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 GeneticVariation disease BEFREE Presenilin-1 is a major causative gene for early onset familial Alzheimer's disease, and the apolipoprotein E epsilon4 allele is a major genetic risk factor known to influence late onset and sporadic early onset Alzheimer's disease. 10329743 1999
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 GeneticVariation disease BEFREE The apolipoprotein E epsilon4 allele frequency was increased among early-onset AD without PSEN mutations. 12433263 2002
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 GeneticVariation disease BEFREE Apolipoprotein E genotype and association between smoking and early onset Alzheimer's disease. 7703749 1995
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 Biomarker disease BEFREE Most rapid cognitive decline in APOE epsilon4 negative Alzheimer's disease with early onset. 19335933 2009
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 SusceptibilityMutation disease CLINVAR APOE4-specific changes in Aβ accumulation in a new transgenic mouse model of Alzheimer disease. 23060451 2012
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 Biomarker disease CTD_human Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. 8346443 1993