Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 GeneticVariation disease BEFREE The effect of the apolipoprotein E (APOE) epsilon 4 allele on age of onset was analyzed in two groups of families with early-onset Alzheimer's disease (AD), (1) Volga German (VG) kindreds, in which AD is caused by an unknown locus and (2) early-onset non-VG families showing evidence of linkage to chromosome 14. 7574468 1995
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 GeneticVariation disease BEFREE Apolipoprotein E genotype and association between smoking and early onset Alzheimer's disease. 7703749 1995
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 GeneticVariation disease BEFREE In our population, there was no evidence for a protective effect of the APOE*2 allele on the risk of EOAD. 7755355 1995
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 Biomarker disease BEFREE Our study demonstrates a significant association between APOE*4 and EOAD which is modified by family history of dementia. 8075646 1994
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 Biomarker disease CTD_human Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. 8346443 1993
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 GeneticVariation disease BEFREE Apolipoprotein E genotype and neuropathological phenotype in two members of a German family with chromosome 14-linked early onset Alzheimer's disease. 8525799 1995
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 GeneticVariation disease BEFREE Apolipoprotein E genotype and concomitant clinical features in early-onset Alzheimer's disease. 8803820 1996
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 GeneticVariation disease BEFREE While the D14S43 and FOS loci showed no association with either early- or late-onset AD, late-onset AD carrying no APOE-epsilon4 allele was associated with the G allele of the T/G polymorphism located at intron 9 of the PS1 gene (P = 0.016). 9180219 1997
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 GeneticVariation disease BEFREE We have found a significantly lower frequency of the presenilin-1 (PS-1) intronic polymorphism 2/2 genotype in early-onset Alzheimer's disease (AD) patients without APOE epsilon4 alleles (2/2 = 0.054; P = 0.009) as compared to age matched non-epsilon4 controls (2/2 = 0.227). 9185685 1997
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 GeneticVariation disease BEFREE These kindreds form the largest collection of AD cases with the same PS-1 mutation and the same educational, environmental, and ethnic background in which to study the phenotypic effect of putative risk factors, such as the epsilon4 allele of apolipoprotein E (ApoE) or head trauma. 9298817 1997
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 GeneticVariation disease BEFREE We conclude, contrary to some previous reports, that the ApoE epsilon2 allele does not increase the risk of early-onset sporadic AD. 9307262 1997
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 SusceptibilityMutation disease CLINVAR Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium. 9343467 1997
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 GeneticVariation disease BEFREE Increases in the frequency of allele 1 homozygotes and in the number of non-apolipoprotein E epsilon4 carrying allele 1 homozygotes/heterozygotes was demonstrated in the early-onset AD cases although these values did not reach significance. 9347936 1997
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 GeneticVariation disease BEFREE The -491 A/T polymorphism in the regulatory region of the apolipoprotein E gene and early-onset Alzheimer's disease. 9875528 1998
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 GeneticVariation disease BEFREE Presenilin-1 is a major causative gene for early onset familial Alzheimer's disease, and the apolipoprotein E epsilon4 allele is a major genetic risk factor known to influence late onset and sporadic early onset Alzheimer's disease. 10329743 1999
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 SusceptibilityMutation disease CLINVAR Dominant negative effects of apolipoprotein E4 revealed in transgenic models of neurodegenerative disease. 10799751 2000
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 GeneticVariation disease BEFREE The frequency of apoE epsilon 4 allele was significantly higher in EOAD patients than in the control group, but not in LOAD patients. 10998553 2000
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 Biomarker disease BEFREE apolipoprotein-E dependent role for the FAS receptor in early onset Alzheimer's disease: finding of a positive association for a polymorphism in the TNFRSF6 gene. 11129341 2000
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 GeneticVariation disease BEFREE The apolipoprotein E epsilon4 allele frequency was increased among early-onset AD without PSEN mutations. 12433263 2002
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 GeneticVariation disease BEFREE presenilin-2 is one of the causative genes for familial Alzheimer's disease, and the apolipoprotein E epsilon4 allele is a major genetic risk factor for late-onset and sporadic early-onset Alzheimer's disease. 16233903 2006
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 GeneticVariation disease BEFREE We asked the following questions: (1) Does early-onset Alzheimer disease (EOAD) occur in families with predominantly LOAD? and (2) Does the apolipoprotein E (APOE) genotype explain the wide differences in onset age in LOAD families? 16966510 2006
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 GeneticVariation disease BEFREE The ApoE4 allele frequency was significantly increased in the patients with eoAD and in those with FTLD. 19091059 2008
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 Biomarker disease BEFREE Most rapid cognitive decline in APOE epsilon4 negative Alzheimer's disease with early onset. 19335933 2009
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 SusceptibilityMutation disease CLINVAR Longitudinal modeling of age-related memory decline and the APOE epsilon4 effect. 19605830 2009
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 Biomarker disease CTD_human Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease. 19734902 2009