Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 Biomarker disease BEFREE apolipoprotein-E dependent role for the FAS receptor in early onset Alzheimer's disease: finding of a positive association for a polymorphism in the TNFRSF6 gene. 11129341 2000
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 GeneticVariation disease BEFREE Apolipoprotein E genotype and association between smoking and early onset Alzheimer's disease. 7703749 1995
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 GeneticVariation disease BEFREE Apolipoprotein E genotype and neuropathological phenotype in two members of a German family with chromosome 14-linked early onset Alzheimer's disease. 8525799 1995
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 GeneticVariation disease BEFREE Apolipoprotein E genotype and concomitant clinical features in early-onset Alzheimer's disease. 8803820 1996
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 SusceptibilityMutation disease CLINVAR APOE4-specific changes in Aβ accumulation in a new transgenic mouse model of Alzheimer disease. 23060451 2012
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 SusceptibilityMutation disease CLINVAR Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy. 23296339 2013
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 Biomarker disease CTD_human Association Analysis of Polymorphisms in TOMM40, CR1, PVRL2, SORL1, PICALM, and 14q32.13 Regions in Colombian Alzheimer Disease Patients. 27023435 2017
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 SusceptibilityMutation disease CLINVAR Association between apolipoprotein E gene polymorphism and the risk of vascular dementia: a meta-analysis. 22381401 2012
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 GeneticVariation disease BEFREE Conversely, patients negative for the APOE ɛ4 allele and with early-onset AD are more likely to be predisposed to vulnerability of cerebral networks beyond the medial temporal lobes. 21185234 2011
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 SusceptibilityMutation disease CLINVAR Differential burden of rare protein truncating variants in Alzheimer's disease patients compared to centenarians. 27260402 2016
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 SusceptibilityMutation disease CLINVAR Dominant negative effects of apolipoprotein E4 revealed in transgenic models of neurodegenerative disease. 10799751 2000
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 SusceptibilityMutation disease CLINVAR Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium. 9343467 1997
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 Biomarker disease CTD_human Elevated serum pesticide levels and risk for Alzheimer disease. 24473795 2014
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 Biomarker disease CTD_human Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. 8346443 1993
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 Biomarker disease CTD_human Genome-Wide Association and Mechanistic Studies Indicate That Immune Response Contributes to Alzheimer's Disease Development. 30319691 2018
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 Biomarker disease CTD_human Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease. 19734902 2009
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 Biomarker disease CTD_human Hidden heterogeneity in Alzheimer's disease: Insights from genetic association studies and other analyses. 29107063 2018
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 GeneticVariation disease BEFREE In late-onset AD, elevated circulating cholesterol levels increase AD risk even after adjusting for the apolipoprotein E ε4 (APOE E4) allele, a major genetic factor for AD and elevated cholesterol levels; however, the role of circulating cholesterol levels in EOAD is unclear. 31135820 2019
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 GeneticVariation disease BEFREE In our population, there was no evidence for a protective effect of the APOE*2 allele on the risk of EOAD. 7755355 1995
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 GeneticVariation disease BEFREE In this study, we identified 5 (8.3%) LPVs and 18 (30%) VUSs in known dementia-related genes in apolipoprotein E ε4 noncarrying Korean patients with early-onset Alzheimer's disease. 31217084 2020
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 GeneticVariation disease BEFREE Increases in the frequency of allele 1 homozygotes and in the number of non-apolipoprotein E epsilon4 carrying allele 1 homozygotes/heterozygotes was demonstrated in the early-onset AD cases although these values did not reach significance. 9347936 1997
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 GeneticVariation disease BEFREE Inverse effect of the APOE epsilon4 allele in late- and early-onset Alzheimer's disease. 26714935 2016
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 SusceptibilityMutation disease CLINVAR Longitudinal modeling of age-related memory decline and the APOE epsilon4 effect. 19605830 2009
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 Biomarker disease CTD_human Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease. 24162737 2013
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 Biomarker disease BEFREE Most rapid cognitive decline in APOE epsilon4 negative Alzheimer's disease with early onset. 19335933 2009