×
Entrez Id:
348
Gene Symbol:
APOE
APOE
0.500
Biomarker
disease
BEFREE
apolipoprotein-E dependent role for the FAS receptor in early onset Alzheimer's disease : finding of a positive association for a polymorphism in the TNFRSF6 gene.
11129341
2000
×
Entrez Id:
348
Gene Symbol:
APOE
APOE
0.500
GeneticVariation
disease
BEFREE
Apolipoprotein E genotype and association between smoking and early onset Alzheimer's disease .
7703749
1995
×
Entrez Id:
348
Gene Symbol:
APOE
APOE
0.500
GeneticVariation
disease
BEFREE
Apolipoprotein E genotype and neuropathological phenotype in two members of a German family with chromosome 14-linked early onset Alzheimer's disease .
8525799
1995
×
Entrez Id:
348
Gene Symbol:
APOE
APOE
0.500
GeneticVariation
disease
BEFREE
Apolipoprotein E genotype and concomitant clinical features in early-onset Alzheimer's disease .
8803820
1996
×
Entrez Id:
348
Gene Symbol:
APOE
APOE
0.500
SusceptibilityMutation
disease
CLINVAR
APOE4-specific changes in Aβ accumulation in a new transgenic mouse model of Alzheimer disease.
23060451
2012
×
Entrez Id:
348
Gene Symbol:
APOE
APOE
0.500
SusceptibilityMutation
disease
CLINVAR
Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy.
23296339
2013
×
Entrez Id:
348
Gene Symbol:
APOE
APOE
0.500
Biomarker
disease
CTD_human
Association Analysis of Polymorphisms in TOMM40, CR1, PVRL2, SORL1, PICALM, and 14q32.13 Regions in Colombian Alzheimer Disease Patients.
27023435
2017
×
Entrez Id:
348
Gene Symbol:
APOE
APOE
0.500
SusceptibilityMutation
disease
CLINVAR
Association between apolipoprotein E gene polymorphism and the risk of vascular dementia: a meta-analysis.
22381401
2012
×
Entrez Id:
348
Gene Symbol:
APOE
APOE
0.500
GeneticVariation
disease
BEFREE
Conversely, patients negative for the APOE ɛ4 allele and with early-onset AD are more likely to be predisposed to vulnerability of cerebral networks beyond the medial temporal lobes.
21185234
2011
×
Entrez Id:
348
Gene Symbol:
APOE
APOE
0.500
SusceptibilityMutation
disease
CLINVAR
Differential burden of rare protein truncating variants in Alzheimer's disease patients compared to centenarians.
27260402
2016
×
Entrez Id:
348
Gene Symbol:
APOE
APOE
0.500
SusceptibilityMutation
disease
CLINVAR
Dominant negative effects of apolipoprotein E4 revealed in transgenic models of neurodegenerative disease.
10799751
2000
×
Entrez Id:
348
Gene Symbol:
APOE
APOE
0.500
SusceptibilityMutation
disease
CLINVAR
Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium.
9343467
1997
×
Entrez Id:
348
Gene Symbol:
APOE
APOE
0.500
Biomarker
disease
CTD_human
Elevated serum pesticide levels and risk for Alzheimer disease.
24473795
2014
×
Entrez Id:
348
Gene Symbol:
APOE
APOE
0.500
Biomarker
disease
CTD_human
Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families.
8346443
1993
×
Entrez Id:
348
Gene Symbol:
APOE
APOE
0.500
Biomarker
disease
CTD_human
Genome-Wide Association and Mechanistic Studies Indicate That Immune Response Contributes to Alzheimer's Disease Development.
30319691
2018
×
Entrez Id:
348
Gene Symbol:
APOE
APOE
0.500
Biomarker
disease
CTD_human
Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease.
19734902
2009
×
Entrez Id:
348
Gene Symbol:
APOE
APOE
0.500
Biomarker
disease
CTD_human
Hidden heterogeneity in Alzheimer's disease: Insights from genetic association studies and other analyses.
29107063
2018
×
Entrez Id:
348
Gene Symbol:
APOE
APOE
0.500
GeneticVariation
disease
BEFREE
In late-onset AD, elevated circulating cholesterol levels increase AD risk even after adjusting for the apolipoprotein E ε4 (APOE E4) allele, a major genetic factor for AD and elevated cholesterol levels; however, the role of circulating cholesterol levels in EOAD is unclear.
31135820
2019
×
Entrez Id:
348
Gene Symbol:
APOE
APOE
0.500
GeneticVariation
disease
BEFREE
In our population, there was no evidence for a protective effect of the APOE *2 allele on the risk of EOAD .
7755355
1995
×
Entrez Id:
348
Gene Symbol:
APOE
APOE
0.500
GeneticVariation
disease
BEFREE
In this study, we identified 5 (8.3%) LPVs and 18 (30%) VUSs in known dementia-related genes in apolipoprotein E ε4 noncarrying Korean patients with early-onset Alzheimer's disease .
31217084
2020
×
Entrez Id:
348
Gene Symbol:
APOE
APOE
0.500
GeneticVariation
disease
BEFREE
Increases in the frequency of allele 1 homozygotes and in the number of non-apolipoprotein E epsilon4 carrying allele 1 homozygotes/heterozygotes was demonstrated in the early-onset AD cases although these values did not reach significance.
9347936
1997
×
Entrez Id:
348
Gene Symbol:
APOE
APOE
0.500
GeneticVariation
disease
BEFREE
Inverse effect of the APOE epsilon4 allele in late- and early-onset Alzheimer's disease .
26714935
2016
×
Entrez Id:
348
Gene Symbol:
APOE
APOE
0.500
SusceptibilityMutation
disease
CLINVAR
Longitudinal modeling of age-related memory decline and the APOE epsilon4 effect.
19605830
2009
×
Entrez Id:
348
Gene Symbol:
APOE
APOE
0.500
Biomarker
disease
CTD_human
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease.
24162737
2013
×
Entrez Id:
348
Gene Symbol:
APOE
APOE
0.500
Biomarker
disease
BEFREE
Most rapid cognitive decline in APOE epsilon4 negative Alzheimer's disease with early onset .
19335933
2009