Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5328
Gene Symbol: PLAU
PLAU 		0.300 Biomarker disease CTD_human
Entrez Id: 351
Gene Symbol: APP
APP 		0.500 Biomarker disease CTD_human "How and when environmental agents and dietary factors affect the course of Alzheimer's disease: the ""LEARn"" model (latent early-life associated regulation) may explain the triggering of AD." 17430250 2007
Entrez Id: 23583
Gene Symbol: SMUG1
SMUG1 		0.010 GeneticVariation disease BEFREE <sup>18</sup>F-FDG PET hypometabolism patterns reflect clinical heterogeneity in sporadic forms of early-onset Alzheimer's disease. 28882421 2017
Entrez Id: 351
Gene Symbol: APP
APP 		0.500 GeneticVariation disease BEFREE Early-onset Alzheimer disease caused by a new mutation (V717L) in the amyloid precursor protein gene. 10867787 2000
Entrez Id: 5663
Gene Symbol: PSEN1
PSEN1 		0.400 GeneticVariation disease BEFREE Early-onset Alzheimer's disease with presenilin-1 M139V mutation: clinical, neuropsychological and neuropathological study. 12752408 2003
Entrez Id: 5663
Gene Symbol: PSEN1
PSEN1 		0.400 GeneticVariation disease BEFREE Early-onset Alzheimer's disease with a de novo mutation in the presenilin 1 gene. 17931627 2007
Entrez Id: 5663
Gene Symbol: PSEN1
PSEN1 		0.400 GeneticVariation disease BEFREE Early-onset Alzheimer disease in an Italian family with presenilin-1 double mutation E318G and G394V. 18525293 2008
Entrez Id: 351
Gene Symbol: APP
APP 		0.500 GeneticVariation disease BEFREE Early-onset Alzheimer disease in this family was associated with a V717G mutation in the amyloid precursor protein gene (APP). 19950418 2010
Entrez Id: 5663
Gene Symbol: PSEN1
PSEN1 		0.400 GeneticVariation disease BEFREE Early-onset Alzheimer's disease (EOAD) is a rare genetic disorder mainly attributable to a mutation in the presenilin 1 (PSEN1) gene. 21212640 2011
Entrez Id: 5663
Gene Symbol: PSEN1
PSEN1 		0.400 GeneticVariation disease BEFREE Early-onset Alzheimer's disease with a presenilin-1 mutation at the site corresponding to the Volga German presenilin-2 mutation. 9225696 1997
Entrez Id: 5664
Gene Symbol: PSEN2
PSEN2 		0.400 GeneticVariation disease BEFREE Early-onset Alzheimer's disease with a presenilin-1 mutation at the site corresponding to the Volga German presenilin-2 mutation. 9225696 1997
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.500 Biomarker disease BEFREE apolipoprotein-E dependent role for the FAS receptor in early onset Alzheimer's disease: finding of a positive association for a polymorphism in the TNFRSF6 gene. 11129341 2000
Entrez Id: 5409
Gene Symbol: PNMT
PNMT 		0.010 GeneticVariation disease BEFREE Phenylethanolamine N-methyltransferase (PNMT) gene and early-onset Alzheimer disease. 11378842 2001
Entrez Id: 5621
Gene Symbol: PRNP
PRNP 		0.320 GeneticVariation disease BEFREE PRNP Val129 homozygosity increases risk for early-onset Alzheimer's disease. 12601712 2003
Entrez Id: 5663
Gene Symbol: PSEN1
PSEN1 		0.400 GeneticVariation disease BEFREE Presenilin 1 mutations in Polish families with early-onset Alzheimer's disease. 15119739 2004
Entrez Id: 20
Gene Symbol: ABCA2
ABCA2 		0.030 Biomarker disease BEFREE ABCA2 is a strong genetic risk factor for early-onset Alzheimer's disease. 15649702 2005
Entrez Id: 5664
Gene Symbol: PSEN2
PSEN2 		0.400 GeneticVariation disease BEFREE presenilin-2 is one of the causative genes for familial Alzheimer's disease, and the apolipoprotein E epsilon4 allele is a major genetic risk factor for late-onset and sporadic early-onset Alzheimer's disease. 16233903 2006
Entrez Id: 351
Gene Symbol: APP
APP 		0.500 GeneticVariation disease BEFREE APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy. 16369530 2006
Entrez Id: 5663
Gene Symbol: PSEN1
PSEN1 		0.400 GeneticVariation disease BEFREE Presenilin 1 gene mutation (M139I) in a patient with an early-onset Alzheimer's disease: clinical characteristics and genetic identification. 20213228 2010
Entrez Id: 5663
Gene Symbol: PSEN1
PSEN1 		0.400 GeneticVariation disease BEFREE PSEN1 codon 163 could be a mutational hot spot in early-onset Alzheimer's disease, and may result in a homogeneous phenotype similar to that of other patients with codon-163 mutations; thus, widening the spectrum of PSEN1 codon-163-linked phenotypes. 23046926 2012
Entrez Id: 54209
Gene Symbol: TREM2
TREM2 		0.330 GeneticVariation disease BEFREE TREM2 R47H variant as a risk factor for early-onset Alzheimer's disease. 23380991 2013
Entrez Id: 5663
Gene Symbol: PSEN1
PSEN1 		0.400 GeneticVariation disease BEFREE PSEN1 L226F mutation in a patient with early-onset Alzheimer's disease in Korea. 27785004 2016
Entrez Id: 5663
Gene Symbol: PSEN1
PSEN1 		0.400 GeneticVariation disease BEFREE Presenilin-1 (PSEN1) mutations are the most common cause of familial early onset Alzheimer's disease (AD). 28550254 2017
Entrez Id: 1804
Gene Symbol: DPP6
DPP6 		0.010 GeneticVariation disease BEFREE DPP6 resequencing identified significantly more rare variants-nonsense, frameshift, and missense-in early-onset Alzheimer's disease (EOAD, p value = 0.03, OR = 2.21 95% CI 1.05-4.82) and frontotemporal dementia (FTD, p = 0.006, OR = 2.59, 95% CI 1.28-5.49) patient cohorts. 30874922 2019
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.500 GeneticVariation disease BEFREE Apolipoprotein E genotype and association between smoking and early onset Alzheimer's disease. 7703749 1995