×
Entrez Id:
341
Gene Symbol:
APOC1
APOC1
0.300
Biomarker
disease
CTD_human
Genome-Wide Association and Mechanistic Studies Indicate That Immune Response Contributes to Alzheimer's Disease Development.
30319691
2018
×
Entrez Id:
341
Gene Symbol:
APOC1
APOC1
0.300
Biomarker
disease
CTD_human
Hidden heterogeneity in Alzheimer's disease: Insights from genetic association studies and other analyses.
29107063
2018
×
Entrez Id:
348
Gene Symbol:
APOE
APOE
0.500
GeneticVariation
disease
BEFREE
Apolipoprotein E genotype and concomitant clinical features in early-onset Alzheimer's disease .
8803820
1996
×
Entrez Id:
348
Gene Symbol:
APOE
APOE
0.500
Biomarker
disease
CTD_human
Association Analysis of Polymorphisms in TOMM40, CR1, PVRL2, SORL1, PICALM, and 14q32.13 Regions in Colombian Alzheimer Disease Patients.
27023435
2017
×
Entrez Id:
348
Gene Symbol:
APOE
APOE
0.500
SusceptibilityMutation
disease
CLINVAR
Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E ϵ4,and the risk of late-onset Alzheimer disease in African Americans.
23571587
2013
×
Entrez Id:
348
Gene Symbol:
APOE
APOE
0.500
GeneticVariation
disease
BEFREE
We have found a significantly lower frequency of the presenilin-1 (PS-1) intronic polymorphism 2/2 genotype in early-onset Alzheimer's disease (AD) patients without APOE epsilon4 alleles (2/2 = 0.054; P = 0.009) as compared to age matched non-epsilon4 controls (2/2 = 0.227).
9185685
1997
×
Entrez Id:
348
Gene Symbol:
APOE
APOE
0.500
Biomarker
disease
BEFREE
Our study demonstrates a significant association between APOE*4 and EOAD which is modified by family history of dementia.
8075646
1994
×
Entrez Id:
348
Gene Symbol:
APOE
APOE
0.500
Biomarker
disease
BEFREE
apolipoprotein-E dependent role for the FAS receptor in early onset Alzheimer's disease : finding of a positive association for a polymorphism in the TNFRSF6 gene.
11129341
2000
×
Entrez Id:
348
Gene Symbol:
APOE
APOE
0.500
GeneticVariation
disease
BEFREE
Inverse effect of the APOE epsilon4 allele in late- and early-onset Alzheimer's disease .
26714935
2016
×
Entrez Id:
348
Gene Symbol:
APOE
APOE
0.500
SusceptibilityMutation
disease
CLINVAR
Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy.
23296339
2013
×
Entrez Id:
348
Gene Symbol:
APOE
APOE
0.500
GeneticVariation
disease
BEFREE
The ApoE4 allele frequency was significantly increased in the patients with eoAD and in those with FTLD.
19091059
2008
×
Entrez Id:
348
Gene Symbol:
APOE
APOE
0.500
Biomarker
disease
CTD_human
Hidden heterogeneity in Alzheimer's disease: Insights from genetic association studies and other analyses.
29107063
2018
×
Entrez Id:
348
Gene Symbol:
APOE
APOE
0.500
SusceptibilityMutation
disease
CLINVAR
Dominant negative effects of apolipoprotein E4 revealed in transgenic models of neurodegenerative disease.
10799751
2000
×
Entrez Id:
348
Gene Symbol:
APOE
APOE
0.500
SusceptibilityMutation
disease
CLINVAR
Longitudinal modeling of age-related memory decline and the APOE epsilon4 effect.
19605830
2009
×
Entrez Id:
348
Gene Symbol:
APOE
APOE
0.500
GeneticVariation
disease
BEFREE
In our population, there was no evidence for a protective effect of the APOE *2 allele on the risk of EOAD .
7755355
1995
×
Entrez Id:
348
Gene Symbol:
APOE
APOE
0.500
Biomarker
disease
CTD_human
Genome-Wide Association and Mechanistic Studies Indicate That Immune Response Contributes to Alzheimer's Disease Development.
30319691
2018
×
Entrez Id:
348
Gene Symbol:
APOE
APOE
0.500
Biomarker
disease
CTD_human
Quantitative Genetics Validates Previous Genetic Variants and Identifies Novel Genetic Players Influencing Alzheimer's Disease Cerebrospinal Fluid Biomarkers.
30320580
2018
×
Entrez Id:
348
Gene Symbol:
APOE
APOE
0.500
GeneticVariation
disease
BEFREE
We conclude, contrary to some previous reports, that the ApoE epsilon2 allele does not increase the risk of early-onset sporadic AD .
9307262
1997
×
Entrez Id:
348
Gene Symbol:
APOE
APOE
0.500
Biomarker
disease
CTD_human
Elevated serum pesticide levels and risk for Alzheimer disease.
24473795
2014
×
Entrez Id:
348
Gene Symbol:
APOE
APOE
0.500
GeneticVariation
disease
BEFREE
Apolipoprotein E genotype and neuropathological phenotype in two members of a German family with chromosome 14-linked early onset Alzheimer's disease .
8525799
1995
×
Entrez Id:
348
Gene Symbol:
APOE
APOE
0.500
GeneticVariation
disease
BEFREE
The results of this study suggest that education and female gender, not APOE genotype, may be important as independent strong predictive factors for disease progression in patients with EOAD .
26444786
2016
×
Entrez Id:
348
Gene Symbol:
APOE
APOE
0.500
GeneticVariation
disease
BEFREE
Presenilin-1 is a major causative gene for early onset familial Alzheimer's disease, and the apolipoprotein E epsilon4 allele is a major genetic risk factor known to influence late onset and sporadic early onset Alzheimer's disease .
10329743
1999
×
Entrez Id:
348
Gene Symbol:
APOE
APOE
0.500
GeneticVariation
disease
BEFREE
The apolipoprotein E epsilon4 allele frequency was increased among early-onset AD without PSEN mutations.
12433263
2002
×
Entrez Id:
348
Gene Symbol:
APOE
APOE
0.500
GeneticVariation
disease
BEFREE
Apolipoprotein E genotype and association between smoking and early onset Alzheimer's disease .
7703749
1995
×
Entrez Id:
348
Gene Symbol:
APOE
APOE
0.500
Biomarker
disease
BEFREE
Most rapid cognitive decline in APOE epsilon4 negative Alzheimer's disease with early onset .
19335933
2009