Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.500 SusceptibilityMutation disease CLINVAR Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E ϵ4,and the risk of late-onset Alzheimer disease in African Americans. 23571587 2013
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.500 SusceptibilityMutation disease CLINVAR Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy. 23296339 2013
Entrez Id: 351
Gene Symbol: APP
APP 		0.500 GeneticVariation disease BEFREE Mutations in the PSEN1, PSEN2, and APP genes seem to be rare in this population, as these genes exhibited no pathogenic mutations in our cohort of eoAD and FTLD patients even though about 40% of the cases were familial ones. 21959359 2013
Entrez Id: 351
Gene Symbol: APP
APP 		0.500 GeneticVariation disease CLINVAR Distinct patterns of APP processing in the CNS in autosomal-dominant and sporadic Alzheimer disease. 23224319 2013
Entrez Id: 351
Gene Symbol: APP
APP 		0.500 Biomarker disease CTD_human Inhibition of human high-affinity copper importer Ctr1 orthologous in the nervous system of Drosophila ameliorates Aβ42-induced Alzheimer's disease-like symptoms. 23827522 2013
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.500 Biomarker disease CTD_human Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease. 24162737 2013
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.500 SusceptibilityMutation disease CLINVAR APOE4-specific changes in Aβ accumulation in a new transgenic mouse model of Alzheimer disease. 23060451 2012
Entrez Id: 351
Gene Symbol: APP
APP 		0.500 GeneticVariation disease BEFREE This is true for HTT, the β-amyloid precursor protein (APP) and presenilins, responsible for early onset Alzheimer's disease (AD). 22489754 2012
Entrez Id: 351
Gene Symbol: APP
APP 		0.500 Biomarker disease CTD_human APP/PS1 transgenic mice treated with aluminum: an update of Alzheimer's disease model. 22507317 2012
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.500 SusceptibilityMutation disease CLINVAR Association between apolipoprotein E gene polymorphism and the risk of vascular dementia: a meta-analysis. 22381401 2012
Entrez Id: 351
Gene Symbol: APP
APP 		0.500 GeneticVariation disease BEFREE Familial forms of CAA are because of mutations in the gene encoding the beta-amyloid precursor protein (APP) and duplications of this gene can cause early-onset Alzheimer's disease associated with CAA. 21463452 2011
Entrez Id: 351
Gene Symbol: APP
APP 		0.500 Biomarker disease CTD_human pH-Dependent Cu(II) coordination to amyloid-β peptide: impact of sequence alterations, including the H6R and D7N familial mutations. 21980910 2011
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.500 GeneticVariation disease BEFREE Retrospective review of clinical data (age at onset, family history, clinical presentation, diagnostic delay, diagnosis) and APOE genotype of patients with neuropathologically confirmed EOAD (<60 years). 21576687 2011
Entrez Id: 351
Gene Symbol: APP
APP 		0.500 AlteredExpression disease BEFREE We analyzed genome-wide interplay between promoter CpG DNA methylation and gene expression in an APP-sw-expressing AD model cell line. 22001921 2011
Entrez Id: 351
Gene Symbol: APP
APP 		0.500 Biomarker disease CTD_human Increasing the predictive accuracy of amyloid-β blood-borne biomarkers in Alzheimer's disease. 21157020 2011
Entrez Id: 351
Gene Symbol: APP
APP 		0.500 GeneticVariation disease BEFREE Mutations in the beta-amyloid precursor protein gene (APP) have been found in familial early-onset Alzheímer's disease (AD). 21424791 2011
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.500 GeneticVariation disease BEFREE Conversely, patients negative for the APOE ɛ4 allele and with early-onset AD are more likely to be predisposed to vulnerability of cerebral networks beyond the medial temporal lobes. 21185234 2011
Entrez Id: 351
Gene Symbol: APP
APP 		0.500 AlteredExpression disease BEFREE Taken together, we propose that the expression of APP-swe modulates global gene expression directed to AD pathogenesis. 21034535 2010
Entrez Id: 351
Gene Symbol: APP
APP 		0.500 Biomarker disease CTD_human Aβ40 oligomers identified as a potential biomarker for the diagnosis of Alzheimer's disease. 21209907 2010
Entrez Id: 351
Gene Symbol: APP
APP 		0.500 Biomarker disease CTD_human On the metal ion (Zn(2+), Cu(2+)) coordination with beta-amyloid peptide: DFT computational study. 20640797 2010
Entrez Id: 351
Gene Symbol: APP
APP 		0.500 GeneticVariation disease BEFREE Early-onset Alzheimer disease in this family was associated with a V717G mutation in the amyloid precursor protein gene (APP). 19950418 2010
Entrez Id: 351
Gene Symbol: APP
APP 		0.500 Biomarker disease CTD_human Early effects of aluminum chloride on beta-secretase mRNA expression in a neuronal model of beta-amyloid toxicity. 20111991 2010
Entrez Id: 351
Gene Symbol: APP
APP 		0.500 Biomarker disease BEFREE These findings strongly implicate APP and the betaCTF of APP, and exclude Abeta and the alphaCTF, as the cause of endocytic pathway dysfunction in DS and AD, underscoring the potential multifaceted value of BACE-1 inhibition in AD therapeutics. 20080541 2010
Entrez Id: 351
Gene Symbol: APP
APP 		0.500 GeneticVariation disease BEFREE The London APP mutation (Val717Ile) associated with early shifting abilities and behavioral changes in two Italian families with early-onset Alzheimer's disease. 20523046 2010
Entrez Id: 351
Gene Symbol: APP
APP 		0.500 Biomarker disease CTD_human Leptin reduces the accumulation of Abeta and phosphorylated tau induced by 27-hydroxycholesterol in rabbit organotypic slices. 20157255 2010