Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4137
Gene Symbol: MAPT
MAPT
0.350 Biomarker disease CTD_human The BET-Bromodomain Inhibitor JQ1 Reduces Inflammation and Tau Phosphorylation at Ser396 in the Brain of the 3xTg Model of Alzheimer's Disease. 27117003 2016
Entrez Id: 4137
Gene Symbol: MAPT
MAPT
0.350 PosttranslationalModification disease BEFREE We measured MAPT promoter methylation in a brain tissue cohort of early-onset Alzheimer's disease (EOAD) with defined causative mutations in the PSEN1 gene (Normal = 10, PSEN1 AD = 10), and idiopathic late-onset Alzheimer's disease (Normal = 12, LOAD = 12). 26159201 2015
Entrez Id: 4137
Gene Symbol: MAPT
MAPT
0.350 Biomarker disease CTD_human Identification of the key molecules involved in chronic copper exposure-aggravated memory impairment in transgenic mice of Alzheimer's disease using proteomic analysis. 25352456 2015
Entrez Id: 4137
Gene Symbol: MAPT
MAPT
0.350 Biomarker disease CTD_human Neurotoxicity induced by okadaic acid in the human neuroblastoma SH-SY5Y line can be differentially prevented by α7 and β2* nicotinic stimulation. 21715663 2011
Entrez Id: 4137
Gene Symbol: MAPT
MAPT
0.350 GeneticVariation disease BEFREE The Swedish mutation (K595N/M596L) of amyloid precursor protein (APP-swe) has been known to increase abnormal cleavage of cellular APP by Beta-secretase (BACE), which causes tau protein hyperphosphorylation and early-onset Alzheimer's disease (AD). 21034535 2010
Entrez Id: 4137
Gene Symbol: MAPT
MAPT
0.350 Biomarker disease CTD_human Leptin reduces the accumulation of Abeta and phosphorylated tau induced by 27-hydroxycholesterol in rabbit organotypic slices. 20157255 2010
Entrez Id: 4137
Gene Symbol: MAPT
MAPT
0.350 GeneticVariation disease BEFREE MAPT exons 1, 2 and 9-13 were sequenced in 59 patients with FTLD, and MAPT haplotypes were analysed in these patients, 122 patients with early onset Alzheimer's disease (eoAD) and 198 healthy controls. 19091059 2008
Entrez Id: 4137
Gene Symbol: MAPT
MAPT
0.350 Biomarker disease BEFREE With AT100, the amount of tau detected in FTDP-17 was 54% (P < 0.001) of that detected in EOAD, but no tau was detected in sporadic FTLD with Pick bodies using this particular antibody. 16866983 2006
Entrez Id: 4137
Gene Symbol: MAPT
MAPT
0.350 Biomarker disease CTD_human Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease--is this type 3 diabetes? 15750215 2005
Entrez Id: 4137
Gene Symbol: MAPT
MAPT
0.350 Biomarker disease CTD_human Tau (MAPT) mutation Arg406Trp presenting clinically with Alzheimer disease does not share a common founder in Western Europe. 14517953 2003
Entrez Id: 4137
Gene Symbol: MAPT
MAPT
0.350 Biomarker disease CTD_human Hypothesis for a common basis for neuroprotection in glaucoma and Alzheimer's disease: anti-apoptosis by alpha-2-adrenergic receptor activation. 12852432 2003
Entrez Id: 4137
Gene Symbol: MAPT
MAPT
0.350 GeneticVariation disease BEFREE Mutation screening of the tau gene in patients with early-onset Alzheimer's disease. 10624829 1999