Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2308
Gene Symbol: FOXO1
FOXO1
0.010 AlteredExpression disease BEFREE We tested the association between FOXO1A cytoplasmic expression and World Health Organization grading system in primary brain tumors (PBTs). 30664534 2020
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.010 AlteredExpression disease BEFREE Although IL-10 is overexpressed and promotes tumor progression in human primary brain tumor, the mechanisms are largely unknown. 31436254 2019
Entrez Id: 55355
Gene Symbol: HJURP
HJURP
0.010 AlteredExpression disease BEFREE The Holliday Junction-Recognition Protein (HJURP) was reported as overexpressed in several cancers and also strongly correlated with poor prognosis of patients, especially in glioblastoma (GBM), the most common and deadly type of primary brain tumor. 31138900 2019
Entrez Id: 29937
Gene Symbol: NENF
NENF
0.010 Biomarker disease BEFREE Serum and cerebrospinal fluid Neudesin concentration and Neudesin Quotient as potential circulating biomarkers of a primary brain tumor. 30953468 2019
Entrez Id: 23583
Gene Symbol: SMUG1
SMUG1
0.010 Biomarker disease BEFREE In addition to primary tumor involvement, PET/CT demonstrated focal FDG uptake in the right temporal lobe suggestive of primary brain tumor or metastasis. 30516682 2019
Entrez Id: 5806
Gene Symbol: PTX3
PTX3
0.010 AlteredExpression disease BEFREE In this study, we not only tested the association between PTX3 expression and the World Health Organization (WHO) tumor grading system but also evaluated overall patient survival under variable expression of PTX3 and Nrf2 in primary brain tumors (PBTs). 30942197 2019
Entrez Id: 4907
Gene Symbol: NT5E
NT5E
0.010 Biomarker disease BEFREE Together, these findings suggest that CD73 and A<sub>2B</sub> AR play a multifaceted role in GB pathogenesis and progression and that targeting the CD73-A<sub>2B</sub> AR axis can benefit GB patients and inform new approaches for therapy to treat GB patients.<b>SIGNIFICANCE STATEMENT</b> Glioblastoma (GB) is the most devastating primary brain tumor. 30926752 2019
Entrez Id: 57670
Gene Symbol: KIAA1549
KIAA1549
0.010 GeneticVariation disease BEFREE Primary brain tumors with KIAA1549-BRAF fusion should not be treated with first-generation BRAFi due to paradoxical activation of the Ras-Raf-MEK-ERK pathway. 30265855 2018
Entrez Id: 57142
Gene Symbol: RTN4
RTN4
0.010 Biomarker disease BEFREE The influence of isoform A of reticulon-4 (Nogo-A), also known as neurite outgrowth inhibitor, on primary brain tumor development was reported. 29861852 2018
Entrez Id: 64398
Gene Symbol: MPP5
MPP5
0.010 Biomarker disease BEFREE Liquid Biopsy in Primary Brain Tumors: Looking for Stardust! 29520561 2018
Entrez Id: 27250
Gene Symbol: PDCD4
PDCD4
0.010 AlteredExpression disease BEFREE A glioblastoma is a common primary brain tumor that expresses microRNA-21 (miR-21), which inhibits the expression of pro-apoptotic genes such as phosphatase and tensin homologue (PTEN) and programmed cell death 4 (PDCD4). 29340361 2018
Entrez Id: 196
Gene Symbol: AHR
AHR
0.010 Biomarker disease BEFREE Investigation of the aryl hydrocarbon receptor and the intrinsic tumoral component of the kynurenine pathway of tryptophan metabolism in primary brain tumors. 29667084 2018
Entrez Id: 5300
Gene Symbol: PIN1
PIN1
0.010 Biomarker disease BEFREE This review will discuss studies providing evidence for multiple roles of PIN1 and other PPIases in glioblastoma and medulloblastoma, the most frequent adult and pediatric primary brain tumors. 30314361 2018
Entrez Id: 4613
Gene Symbol: MYCN
MYCN
0.010 AlteredExpression disease BEFREE Prognostic significance of MYCN gene amplification and protein expression in primary brain tumors: Astrocytoma and meningioma. 28453467 2017
Entrez Id: 2688
Gene Symbol: GH1
GH1
0.010 Biomarker disease BEFREE Here we present two NS patients who developed different primary brain tumors while being on growth hormone therapy. 28746941 2017
Entrez Id: 51742
Gene Symbol: ARID4B
ARID4B
0.010 Biomarker disease BEFREE Therefore, ARID4B is a satisfactory biomarker to highlight tumour component and predict tumour behaviour in primary brain neoplasms. 27451434 2017
Entrez Id: 7421
Gene Symbol: VDR
VDR
0.010 AlteredExpression disease BEFREE The top 370 probe sets that were differentially expressed between BCBM and both BC and prBT were in the majority comparably overexpressed in BCBM and included, e.g. the coding genes BCL3, BNIP3, BNIP3P1, BRIP1, CASP14, CDC25A, DMBT1, IDH2, E2F1, MYCN, RAD51, RAD54L, and VDR. 29287594 2017
Entrez Id: 8438
Gene Symbol: RAD54L
RAD54L
0.010 AlteredExpression disease BEFREE The top 370 probe sets that were differentially expressed between BCBM and both BC and prBT were in the majority comparably overexpressed in BCBM and included, e.g. the coding genes BCL3, BNIP3, BNIP3P1, BRIP1, CASP14, CDC25A, DMBT1, IDH2, E2F1, MYCN, RAD51, RAD54L, and VDR. 29287594 2017
Entrez Id: 4035
Gene Symbol: LRP1
LRP1
0.010 Biomarker disease BEFREE The role of CXCR3/LRP1 cross-talk in the invasion of primary brain tumors. 29146996 2017
Entrez Id: 10630
Gene Symbol: PDPN
PDPN
0.010 AlteredExpression disease BEFREE In conclusion, high podoplanin expression in primary brain tumors induces platelet aggregation, correlates with hypercoagulability, and is associated with increased risk of VTE. 28073783 2017
Entrez Id: 3587
Gene Symbol: IL10RA
IL10RA
0.010 AlteredExpression disease BEFREE The aim of this study was to assess the expression of IL10R in CD45<sup>+</sup> cells within primary brain tumors and metastases and establish its association with tumor basic immunophenotype. 28982901 2017
Entrez Id: 5340
Gene Symbol: PLG
PLG
0.010 AlteredExpression disease BEFREE Expression and activity of the urokinase plasminogen activator system in canine primary brain tumors. 28442916 2017
Entrez Id: 602
Gene Symbol: BCL3
BCL3
0.010 AlteredExpression disease BEFREE The top 370 probe sets that were differentially expressed between BCBM and both BC and prBT were in the majority comparably overexpressed in BCBM and included, e.g. the coding genes BCL3, BNIP3, BNIP3P1, BRIP1, CASP14, CDC25A, DMBT1, IDH2, E2F1, MYCN, RAD51, RAD54L, and VDR. 29287594 2017
Entrez Id: 842
Gene Symbol: CASP9
CASP9
0.010 Biomarker disease BEFREE Future studies with a larger sample size will clarify the possible roles of CASP-9 gene in the etiology and progression of primary brain tumors. 28870924 2017
Entrez Id: 468
Gene Symbol: ATF4
ATF4
0.010 AlteredExpression disease BEFREE Here we show that ATF4 expression fosters the malignancy of primary brain tumors (WHO grade III and IV gliomas) and increases proliferation and tumor angiogenesis. 28553953 2017