Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6648
Gene Symbol: SOD2
SOD2 		0.300 Biomarker disease CTD_human Hydrogen peroxide contributes to the manganese superoxide dismutase promotion of migration and invasion in glioma cells. 21749277 2011
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA 		0.300 Biomarker disease CTD_human Naringenin, a flavanone inhibits the proliferation of cerebrally implanted C6 glioma cells in rats. 20932960 2011
Entrez Id: 1019
Gene Symbol: CDK4
CDK4 		0.300 Biomarker disease CTD_human Naringenin, a flavanone inhibits the proliferation of cerebrally implanted C6 glioma cells in rats. 20932960 2011
Entrez Id: 28514
Gene Symbol: DLL1
DLL1 		0.300 Biomarker disease CTD_human Inhibition of notch signaling blocks growth of glioblastoma cell lines and tumor neurospheres. 21127729 2010
Entrez Id: 441478
Gene Symbol: NRARP
NRARP 		0.300 Biomarker disease CTD_human Inhibition of notch signaling blocks growth of glioblastoma cell lines and tumor neurospheres. 21127729 2010
Entrez Id: 113878
Gene Symbol: DTX2
DTX2 		0.300 Biomarker disease CTD_human Inhibition of notch signaling blocks growth of glioblastoma cell lines and tumor neurospheres. 21127729 2010
Entrez Id: 388585
Gene Symbol: HES5
HES5 		0.300 Biomarker disease CTD_human Inhibition of notch signaling blocks growth of glioblastoma cell lines and tumor neurospheres. 21127729 2010
Entrez Id: 1612
Gene Symbol: DAPK1
DAPK1 		0.300 Biomarker disease CTD_human DAPK1 promoter hypermethylaiton in brain metastases and peripheral blood. 17319784 2007
Entrez Id: 1559
Gene Symbol: CYP2C9
CYP2C9 		0.300 Biomarker disease CTD_human CYP2C9 polymorphisms in human tumors. 16475710 2006
Entrez Id: 6696
Gene Symbol: SPP1
SPP1 		0.300 Biomarker disease CTD_human Osteopontin expression in intratumoral astrocytes marks tumor progression in gliomas induced by prenatal exposure to N-ethyl-N-nitrosourea. 16651633 2006
Entrez Id: 5444
Gene Symbol: PON1
PON1 		0.300 Biomarker disease CTD_human Risk of brain tumors in children and susceptibility to organophosphorus insecticides: the potential role of paraoxonase (PON1). 16002382 2005
Entrez Id: 7052
Gene Symbol: TGM2
TGM2 		0.300 Therapeutic disease CTD_human Tissue transglutaminase 2 inhibition promotes cell death and chemosensitivity in glioblastomas. 16170020 2005
Entrez Id: 6608
Gene Symbol: SMO
SMO 		0.300 Biomarker disease CTD_human Missense mutations in SMOH in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system. 9581815 1998
Entrez Id: 5727
Gene Symbol: PTCH1
PTCH1 		0.300 Biomarker disease CTD_human Missense mutations in SMOH in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system. 9581815 1998
Entrez Id: 3558
Gene Symbol: IL2
IL2 		0.300 Biomarker disease CTD_human Cytokinetic basis for the impaired activation of lymphocytes from patients with primary intracranial tumors. 6319491 1984
Entrez Id: 7157
Gene Symbol: TP53
TP53 		0.220 Biomarker disease CTD_mouse Evaluation of genetic alterations in cancer-related genes in lung and brain tumors from B6C3F1 mice exposed to 1,3-butadiene or chloroprene. 16860786 2007
Entrez Id: 7157
Gene Symbol: TP53
TP53 		0.220 GeneticVariation disease BEFREE Frequency of p53 tumor suppressor gene mutations in human primary brain tumors. 7903434 1993
Entrez Id: 7157
Gene Symbol: TP53
TP53 		0.220 GeneticVariation disease BEFREE In contrast, the frequency of Tp53 mutations in the primary brain tumors examined was lower (5.7%). 8268922 1993
Entrez Id: 1956
Gene Symbol: EGFR
EGFR 		0.050 GeneticVariation disease BEFREE Erlotinib (Tarceva<sup>®</sup>), a potent small molecule inhibitor of the epidermal growth factor receptor tyrosine kinase, has been evaluated to treat infants and children with primary brain tumors. 31392390 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR 		0.050 Biomarker disease BEFREE The Epidermal Growth Factor Receptor gene has been reported to be involved in the progression of gliomas which is one of the deadliest primary brain tumors in humans. 28938685 2017
Entrez Id: 1956
Gene Symbol: EGFR
EGFR 		0.050 GeneticVariation disease BEFREE Amplification of the epidermal growth factor receptor (EGFR) and its mutant EGFRvIII are among the most common genetic alterations in glioblastoma (GBM), the most frequent and most aggressive primary brain tumor. 27286795 2016
Entrez Id: 1956
Gene Symbol: EGFR
EGFR 		0.050 GeneticVariation disease BEFREE Glioblastoma (GBM) is the most common primary brain tumor in adults and often has amplification of the epidermal growth factor receptor (EGFR) gene. 22472960 2012
Entrez Id: 960
Gene Symbol: CD44
CD44 		0.050 AlteredExpression disease BEFREE The homing receptor CD44 is frequently expressed on primary brain tumors and brain metastases. 11136998 2000
Entrez Id: 1956
Gene Symbol: EGFR
EGFR 		0.050 GeneticVariation disease BEFREE A frequent genetic alteration in primary brain tumors such as gliomas is an in-frame deletion in the epidermal growth factor receptor (EGFR) gene EGFRvIII, which brings together what were normally distant polypeptide sequences in the intact receptor. 10499644 1999
Entrez Id: 960
Gene Symbol: CD44
CD44 		0.050 AlteredExpression disease BEFREE Standard CD44 was found to be expressed by the majority of primary brain tumors and brain metastases. 8651925 1996