Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.320 AlteredExpression phenotype BEFREE The depletion of MDMs by clodronate liposomes alleviated diabetes-induced tactile allodynia (<i>P</i> < 0.05) and reduced the infiltration of MDMs (<i>P</i> < 0.001) as well as the expression of IL-1<i>β</i> and TNF-<i>α</i> in the spinal cord (<i>P</i> < 0.05). 31534976 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.320 AlteredExpression phenotype BEFREE Overexpression of TNF was also associated with pelvic tactile allodynia. 29465304 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.320 Biomarker phenotype CTD_human Resveratrol suppresses glial activation and alleviates trigeminal neuralgia via activation of AMPK. 27093858 2016
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.320 Biomarker phenotype CTD_human Citronellol, a natural acyclic monoterpene, attenuates mechanical hyperalgesia response in mice: Evidence of the spinal cord lamina I inhibition. 26141506 2015
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.320 Biomarker phenotype CTD_human Resolvins RvE1 and RvD1 attenuate inflammatory pain via central and peripheral actions. 20383154 2010
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.320 Biomarker phenotype CTD_human Endogenous tumor necrosis factor alpha (TNFalpha) requires TNF receptor type 2 to generate heat hyperalgesia in a mouse cancer model. 18463260 2008
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.320 Biomarker phenotype CTD_human Tumor necrosis factor alpha enhances the sensitivity of rat trigeminal neurons to capsaicin. 18582539 2008
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.320 Biomarker phenotype CTD_human Anti-inflammatory and analgesic effects of the sesquiterpene lactone budlein A in mice: inhibition of cytokine production-dependent mechanism. 17320857 2007
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.320 Biomarker phenotype CTD_human Mitochondrial electron transport in models of neuropathic and inflammatory pain. 16472913 2006
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.320 Biomarker phenotype CTD_human Hyperalgesia induced by Asp49 and Lys49 phospholipases A2 from Bothrops asper snake venom: pharmacological mediation and molecular determinants. 12727271 2003
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.320 Biomarker phenotype CTD_human Pharmacological modulation of secondary mediator systems--cyclic AMP and cyclic GMP--on inflammatory hyperalgesia. 10401557 1999
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.320 Biomarker phenotype CTD_human S14080, a peripheral analgesic acting by release of an endogenous circulating opioid-like substance. 7881729 1995
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.320 Biomarker phenotype CTD_human Cytokine-mediated inflammatory hyperalgesia limited by interleukin-10. 7582491 1995
Entrez Id: 7442
Gene Symbol: TRPV1
TRPV1 		0.310 Biomarker phenotype BEFREE In contrast, TRPV1 KO mice with EAP do not develop pelvic tactile allodynia at any time point. 31573117 2020
Entrez Id: 796
Gene Symbol: CALCA
CALCA 		0.310 Biomarker phenotype BEFREE Salmon calcitonin exerts better preventive effects than celecoxib on lumbar facet joint degeneration and long-term tactile allodynia in rats. 30826485 2019
Entrez Id: 6863
Gene Symbol: TAC1
TAC1 		0.310 AlteredExpression phenotype BEFREE Ultrasound therapy reduces persistent post-thoracotomy tactile allodynia and spinal substance P expression in rats. 30902913 2019
Entrez Id: 3553
Gene Symbol: IL1B
IL1B 		0.310 Biomarker phenotype BEFREE Red nucleus interleukin-1β evokes tactile allodynia through activation of JAK/STAT3 and JNK signaling pathways. 30216497 2018
Entrez Id: 3146
Gene Symbol: HMGB1
HMGB1 		0.310 Biomarker phenotype BEFREE Finally, we found that repeated blockade of either Sigma-1R or HMGB1 in the spinal cord after STZ treatment prevent the development of tactile allodynia and thermal hyperalgesia at 1 week. 29421543 2018
Entrez Id: 796
Gene Symbol: CALCA
CALCA 		0.310 Therapeutic phenotype CTD_human Resveratrol suppresses glial activation and alleviates trigeminal neuralgia via activation of AMPK. 27093858 2016
Entrez Id: 3553
Gene Symbol: IL1B
IL1B 		0.310 Biomarker phenotype CTD_human Resveratrol suppresses glial activation and alleviates trigeminal neuralgia via activation of AMPK. 27093858 2016
Entrez Id: 3146
Gene Symbol: HMGB1
HMGB1 		0.310 Biomarker phenotype CTD_human Involvement of high mobility group box 1 in the development and maintenance of chemotherapy-induced peripheral neuropathy in rats. 27474498 2016
Entrez Id: 796
Gene Symbol: CALCA
CALCA 		0.310 Biomarker phenotype CTD_human Resveratrol suppresses glial activation and alleviates trigeminal neuralgia via activation of AMPK. 27093858 2016
Entrez Id: 7442
Gene Symbol: TRPV1
TRPV1 		0.310 Biomarker phenotype CTD_human The cytochrome P450 inhibitor, ketoconazole, inhibits oxidized linoleic acid metabolite-mediated peripheral inflammatory pain. 23006841 2012
Entrez Id: 3553
Gene Symbol: IL1B
IL1B 		0.310 Biomarker phenotype CTD_human Interleukin-1 receptor antagonist ameliorates neonatal lipopolysaccharide-induced long-lasting hyperalgesia in the adult rats. 20937348 2011
Entrez Id: 7442
Gene Symbol: TRPV1
TRPV1 		0.310 Biomarker phenotype CTD_human TRPV1 receptor in expression of opioid-induced hyperalgesia. 18774343 2009