Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 51684
Gene Symbol: SUFU
SUFU
0.740 Biomarker disease GENOMICS_ENGLAND Germline mutations in SUFU cause Gorlin syndrome-associated childhood medulloblastoma and redefine the risk associated with PTCH1 mutations. 25403219 2014
Entrez Id: 51684
Gene Symbol: SUFU
SUFU
0.740 SusceptibilityMutation disease ORPHANET These data indicate that germline SUFU mutations were responsible for a high proportion of desmoplastic medulloblastoma in children younger than 3 years of age. 22508808 2012
Entrez Id: 51684
Gene Symbol: SUFU
SUFU
0.740 GeneticVariation disease BEFREE These data indicate that germline SUFU mutations were responsible for a high proportion of desmoplastic medulloblastoma in children younger than 3 years of age. 22508808 2012
Entrez Id: 51684
Gene Symbol: SUFU
SUFU
0.740 SusceptibilityMutation disease ORPHANET The SUFU mutations were identified in two of the 16 individuals with desmoplastic medulloblastomas. 21188540 2011
Entrez Id: 51684
Gene Symbol: SUFU
SUFU
0.740 GeneticVariation disease BEFREE The SUFU mutations were identified in two of the 16 individuals with desmoplastic medulloblastomas. 21188540 2011
Entrez Id: 51684
Gene Symbol: SUFU
SUFU
0.740 SusceptibilityMutation disease ORPHANET Incomplete penetrance of the predisposition to medulloblastoma associated with germ-line SUFU mutations. 19833601 2010
Entrez Id: 51684
Gene Symbol: SUFU
SUFU
0.740 Biomarker disease BEFREE Previous studies revealed mutations in genes encoding members of the sonic hedgehog pathway, including PTCH, SMOH and SUFUH in DMBs. 16400626 2006
Entrez Id: 51684
Gene Symbol: SUFU
SUFU
0.740 SusceptibilityMutation disease ORPHANET Mutations in SUFU predispose to medulloblastoma. 12068298 2002
Entrez Id: 51684
Gene Symbol: SUFU
SUFU
0.740 GeneticVariation disease BEFREE The identification of SUFU mutations in desmoplastic medulloblastoma provides new insights into vertebrate Hedgehog signaling and brain tumor formation. 12150819 2002
Entrez Id: 51684
Gene Symbol: SUFU
SUFU
0.740 CausalMutation disease CLINVAR
Entrez Id: 51684
Gene Symbol: SUFU
SUFU
0.740 Biomarker disease CTD_human
Entrez Id: 5727
Gene Symbol: PTCH1
PTCH1
0.320 Biomarker disease CTD_human Antitumor effects of a combined 5-aza-2'deoxycytidine and valproic acid treatment on rhabdomyosarcoma and medulloblastoma in Ptch mutant mice. 19155313 2009
Entrez Id: 5727
Gene Symbol: PTCH1
PTCH1
0.320 Biomarker disease CTD_human Bortezomib reverses a post-translational mechanism of tumorigenesis for patched1 haploinsufficiency in medulloblastoma. 19213072 2009
Entrez Id: 5727
Gene Symbol: PTCH1
PTCH1
0.320 Biomarker disease CTD_human Cooperation between the Hic1 and Ptch1 tumor suppressors in medulloblastoma. 18347096 2008
Entrez Id: 5727
Gene Symbol: PTCH1
PTCH1
0.320 Biomarker disease BEFREE Previous studies revealed mutations in genes encoding members of the sonic hedgehog pathway, including PTCH, SMOH and SUFUH in DMBs. 16400626 2006
Entrez Id: 5727
Gene Symbol: PTCH1
PTCH1
0.320 GeneticVariation disease BEFREE The authors present the case of a 2.5-year-old African-American boy with desmoplastic medulloblastoma (MB) and nevoid basal cell carcinoma syndrome (NBCCS), also known as Gorlin syndrome, an autosomal dominant disorder resulting from mutations in the patched (PTCH) gene that predisposes to neoplasias (including basal cell carcinomas [BCCs] and MB) and to widespread congenital malformations. 17328283 2006
Entrez Id: 23081
Gene Symbol: KDM4C
KDM4C
0.310 Biomarker disease CTD_human Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma. 19270706 2009
Entrez Id: 23081
Gene Symbol: KDM4C
KDM4C
0.310 GeneticVariation disease BEFREE Further analysis of the 9p and 17q22-q24 amplicons by array-based CGH (matrix-CGH) and candidate gene analyses revealed amplification of JMJD2C at 9p24 in one DMB and amplification of RPS6KB1, APPBP2, PPM1D and BCAS3 from 17q23 in three DMBs. 16400626 2006
Entrez Id: 6046
Gene Symbol: BRD2
BRD2
0.300 Biomarker disease CTD_human BET bromodomain protein inhibition is a therapeutic option for medulloblastoma. 24231268 2013
Entrez Id: 1021
Gene Symbol: CDK6
CDK6
0.300 Biomarker disease CTD_human Inhibition of cyclin-dependent kinase 6 suppresses cell proliferation and enhances radiation sensitivity in medulloblastoma cells. 23138228 2013
Entrez Id: 8019
Gene Symbol: BRD3
BRD3
0.300 Biomarker disease CTD_human BET bromodomain protein inhibition is a therapeutic option for medulloblastoma. 24231268 2013
Entrez Id: 23476
Gene Symbol: BRD4
BRD4
0.300 Biomarker disease CTD_human BET bromodomain protein inhibition is a therapeutic option for medulloblastoma. 24231268 2013
Entrez Id: 92335
Gene Symbol: STRADA
STRADA
0.300 Biomarker disease CTD_human A sensitized RNA interference screen identifies a novel role for the PI3K p110γ isoform in medulloblastoma cell proliferation and chemoresistance. 21652733 2011
Entrez Id: 11186
Gene Symbol: RASSF1
RASSF1
0.300 Biomarker disease CTD_human RASSF1A and the BH3-only mimetic ABT-737 promote apoptosis in pediatric medulloblastoma cell lines. 21880625 2011
Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
0.300 Biomarker disease CTD_human A sensitized RNA interference screen identifies a novel role for the PI3K p110γ isoform in medulloblastoma cell proliferation and chemoresistance. 21652733 2011