Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 351
Gene Symbol: APP
APP
0.400 Biomarker phenotype BEFREE TDP-43 inhibitory peptide alleviates neurodegeneration and memory loss in an APP transgenic mouse model for Alzheimer's disease. 31678156 2020
Entrez Id: 351
Gene Symbol: APP
APP
0.400 Biomarker phenotype BEFREE The elevation of Rac1 activity not only accelerated 6-hour spatial memory decay in 3-month-old APP/PS1 mice, but also significantly contributed to severe memory loss in aged APP/PS1 mice. 31321704 2019
Entrez Id: 351
Gene Symbol: APP
APP
0.400 Biomarker phenotype BEFREE More importantly, the Pt<sup>II</sup> -PW<sub>11</sub> greatly reduced Aβ deposition and rescued memory loss in APP/PS1 transgenic AD model mice without noticeable cytotoxicity, demonstrating its potential as drugs for AD treatment. 31591753 2019
Entrez Id: 351
Gene Symbol: APP
APP
0.400 AlteredExpression phenotype BEFREE Somatostatin (SST) blocks the aggregation of and inflammation whereas reduction of SST levels in the CSF and brain tissue is associated with impaired cognitive function and memory loss. 29700775 2019
Entrez Id: 351
Gene Symbol: APP
APP
0.400 Biomarker phenotype BEFREE Here, we use the J20-APP AD mouse model that displays spatial memory loss as well as reduced slow gamma amplitude and phase-amplitude coupling to theta oscillations phase. 31757962 2019
Entrez Id: 351
Gene Symbol: APP
APP
0.400 Biomarker phenotype BEFREE Autophagy impairment by caspase-1-dependent inflammation mediates memory loss in response to β-Amyloid peptide accumulation. 28801921 2018
Entrez Id: 351
Gene Symbol: APP
APP
0.400 Biomarker phenotype CTD_human Virgin coconut oil (VCO) by normalizing NLRP3 inflammasome showed potential neuroprotective effects in Amyloid-β induced toxicity and high-fat diet fed rat. 29729307 2018
Entrez Id: 351
Gene Symbol: APP
APP
0.400 Biomarker phenotype BEFREE A CNS-permeable Hsp90 inhibitor rescues synaptic dysfunction and memory loss in APP-overexpressing Alzheimer's mouse model via an HSF1-mediated mechanism. 27457810 2017
Entrez Id: 351
Gene Symbol: APP
APP
0.400 Biomarker phenotype CTD_human Oral administration of methysticin improves cognitive deficits in a mouse model of Alzheimer's disease. 28448946 2017
Entrez Id: 351
Gene Symbol: APP
APP
0.400 Biomarker phenotype BEFREE Three months of treatment of AAV9-GFP-CIP reduced pathologic changes, including τ hyperphosphorylation, (Aβ) deposit, astrocytosis, and microgliosis, which were correlated with the reversal of memory loss and anxiety-like behavior observed in APP/PS1 mice. 28420695 2017
Entrez Id: 351
Gene Symbol: APP
APP
0.400 AlteredExpression phenotype BEFREE Treatment of 3xTg-AD mice with flavocoxid reduced: (1) learning and memory loss; (2) the increased eicosanoid production and the phosphorylation level of amyloid precursor protein (APP-pThr668), Aβ 1-42, p-tau (pThr181), pERK, and the activation of the NLRP3 inflammasome; (3) Aβ plaques; and (4) neuronal loss, compared to saline-treated animals. 28238167 2017
Entrez Id: 351
Gene Symbol: APP
APP
0.400 Biomarker phenotype BEFREE APP/PS1 double-transgenic mice treated with 3F5 mAb showed reduced memory loss, cognitive decline, and decreased levels of amyloid deposits in the brain. 28662102 2017
Entrez Id: 351
Gene Symbol: APP
APP
0.400 AlteredExpression phenotype BEFREE Presenilin 1 transgene addition to amyloid precursor protein overexpressing transgenic rats increases amyloid beta 42 levels and results in loss of memory retention. 27388605 2016
Entrez Id: 351
Gene Symbol: APP
APP
0.400 Biomarker phenotype CTD_human [Gly14]-Humanin Protects Against Amyloid β Peptide-Induced Impairment of Spatial Learning and Memory in Rats. 27306655 2016
Entrez Id: 351
Gene Symbol: APP
APP
0.400 Biomarker phenotype CTD_human Lactational exposure of mice to low levels of non-dioxin-like polychlorinated biphenyls increases susceptibility to neuronal stress at a mature age. 26480858 2016
Entrez Id: 351
Gene Symbol: APP
APP
0.400 Biomarker phenotype CTD_human Ethosuximide Induces Hippocampal Neurogenesis and Reverses Cognitive Deficits in an Amyloid-β Toxin-induced Alzheimer Rat Model via the Phosphatidylinositol 3-Kinase (PI3K)/Akt/Wnt/β-Catenin Pathway. 26420483 2015
Entrez Id: 351
Gene Symbol: APP
APP
0.400 Biomarker phenotype CTD_human Selective activation of α7 nicotinic acetylcholine receptor by PHA-543613 improves Aβ25-35-mediated cognitive deficits in mice. 25881725 2015
Entrez Id: 351
Gene Symbol: APP
APP
0.400 Biomarker phenotype CTD_human Potassium 2-(1-hydroxypentyl)-benzoate promotes long-term potentiation in Aβ1-42-injected rats and APP/PS1 transgenic mice. 24858312 2014
Entrez Id: 351
Gene Symbol: APP
APP
0.400 Biomarker phenotype CTD_human Notoginsenoside R1 increases neuronal excitability and ameliorates synaptic and memory dysfunction following amyloid elevation. 25213453 2014
Entrez Id: 351
Gene Symbol: APP
APP
0.400 Biomarker phenotype CTD_human Inhibition of human high-affinity copper importer Ctr1 orthologous in the nervous system of Drosophila ameliorates Aβ42-induced Alzheimer's disease-like symptoms. 23827522 2013
Entrez Id: 351
Gene Symbol: APP
APP
0.400 Biomarker phenotype CTD_human Protective effects of astragalosides on dexamethasone and Aβ25-35 induced learning and memory impairments due to decrease amyloid precursor protein expression in 12-month male rats. 22484447 2012
Entrez Id: 351
Gene Symbol: APP
APP
0.400 Biomarker phenotype BEFREE The amyloid precursor protein (APP) and its cleavage product Aβ play central roles in synapse and memory loss, and thus are strongly implicated in the pathogenesis of AD. 21199446 2012
Entrez Id: 351
Gene Symbol: APP
APP
0.400 Biomarker phenotype BEFREE Transgene expression of familial Alzheimer's disease-linked mutants of β-amyloid precursor protein (APP) and presenilin-1 leads to a significant inhibition of neurogenesis, which is potentially linked to age-dependent memory loss. 22042871 2011
Entrez Id: 351
Gene Symbol: APP
APP
0.400 Biomarker phenotype BEFREE Functionally, removing CX3CR1 in human amyloid precursor protein mice worsened the memory retention in passive avoidance and novel object recognition tests, and their memory loss in the novel object recognition test is associated with high levels of interleukin 6. 21771791 2011
Entrez Id: 351
Gene Symbol: APP
APP
0.400 Biomarker phenotype BEFREE The brain formaldehyde level in APP/PS1-transgenic (n=8) mice at age of 3 months and APP-transgenic (n=8) mice at age of 6 months was increased (0.56 ± 0.02 mM), respectively, as compared with their respective age-matched controls, when these two types of AD-like animals, respectively, started to form Aβ deposits and memory loss obviously. 19879019 2011