ARHGAP24
|
0.060 |
PosttranslationalModification
|
disease |
BEFREE |
A total of 124 of 160 glioma samples (77.5%) displayed CpG island hypermethylation of both p73, p21 genes associated with the loss of mRNA expression (P < 0.001) and the loss of protein expressions (p53 independent p21 expression). p73 gene showed increased methylation frequency in all grades, 40 of 60 (66%) glioblastomas and 16 of 30 (53.3%) anaplastic astrocytoma, 10 of 20(50%) oligodendrogliomas, 8 of 20 (40%) ependymoma, and low-grade glioma 6 of 20 (30%).
|
20844987 |
2011 |
ARHGAP24
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
The p73 gene encodes a protein structurally and functionally homologous to TP53, and maps to chromosomal band 1p36.33, where loss of heterozygosity has been observed in up to 90% of oligodendrogliomas and in 10-25% of diffuse astrocytomas.
|
12200621 |
2002 |
ARHGAP24
|
0.060 |
Biomarker
|
disease |
BEFREE |
To determine whether p73 is involved in nonastrocytic brain tumour development, we analysed 65 tumour samples including 26 oligodendrogliomas, 4 ependymomas, 5 medulloblastomas, 10 meningiomas, 2 meningeal haemangiopericytomas, 2 neurofibrosarcomas, 3 primary lymphomas, 8 schwannomas and 5 metastatic tumours to the brain, for p73 alterations.
|
11461077 |
2001 |
ARHGAP24
|
0.060 |
Biomarker
|
disease |
BEFREE |
The p73 gene is thus unlikely to be a tumor suppressor gene for oligodendrogliomas.
|
10953317 |
2000 |
ARHGAP24
|
0.060 |
Biomarker
|
disease |
BEFREE |
Thus far, mutation analysis has provided no evidence for involvement of p73 in oligodendrogliomas, lung carcinoma, oesophageal carcinoma, prostatic carcinoma and hepatocellular carcinoma.
|
10732753 |
2000 |
ARHGAP24
|
0.060 |
Biomarker
|
disease |
BEFREE |
To determine whether p73 is a potential tumor suppressor gene involved in the development of oligodendrogliomas, we performed mutation analysis of p73 in oligodendrogliomas with chromosome 1 p-arm deletions.
|
9721206 |
1998 |