|
TRBV20OR9-2
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The most immature B lineage ALL ('null' ALL) has a much lower frequency of TCR gene rearrangement than the common variant of B cell precursor ALL and also has a high frequency of oligoclonal rearrangements of IgH genes.
|
3118113 |
1987 |
|
TRBV20OR9-2
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
T cell rearranging gene gamma (TRG gamma) and T cell antigen receptor beta (TCR beta) chain gene rearrangement and transcription were studied in a series of patients with B-lineage acute lymphoblastic leukemia (ALL), in which the Ig H chain genes are rearranged and the surface phenotype reproduces the stages of normal pre-B maturation.
|
2951478 |
1987 |
|
TRBV20OR9-2
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
TCR-delta rearrangements or deletions were found in all T (33 cases) and B lineage (28 cases) ALL but not in any case of B cell chronic proliferations (13 cases).
|
2523429 |
1989 |
|
TRBV20OR9-2
|
0.100 |
Biomarker
|
disease |
BEFREE |
We next analyzed TCR delta rearrangements in five CD3+TCR gamma/delta+ ALL and cell lines.
|
2547833 |
1989 |
|
TRBV20OR9-2
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
However, concomitant rearrangements of Ig and TcR genes have been commonly reported in the most immature lymphoid malignancies, mainly in B-cell precursor acute lymphoblastic leukemia (ALL).
|
2331523 |
1990 |
|
TRBV20OR9-2
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Immunoglobulin (Ig) and T-cell receptor (TCR) genes were examined in the lymphoblasts of 70 children with immunophenotypically defined B-cell precursor acute lymphoblastic leukemia (ALL).
|
2307988 |
1990 |
|
TRBV20OR9-2
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Rearrangements of both Ig and TCR genes (double rearrangements) were detected in 24 patients, including three (19%) of 16 T-lineage ALL.
|
1850056 |
1991 |
|
TRBV20OR9-2
|
0.100 |
Biomarker
|
disease |
BEFREE |
Using the polymerase chain reaction (PCR) amplification of rearranged T-cell receptor delta(TCR delta)-chain junctional sequences for the preparation of clonospecific probes, we performed a retrospective PCR study of remission bone marrow (BM) samples in seven pediatric patients with ALL who subsequently relapsed (the largest series studied so far) and in 10 patients who were in longterm (greater than 39 to greater than 72 months) remission.
|
1316978 |
1992 |
|
TRBV20OR9-2
|
0.100 |
Biomarker
|
disease |
BEFREE |
A case of acute lymphoblastic leukemia (ALL) was encountered in which the two clonal gamma T-cell receptor gene (TCR gamma) rearrangements found in bone marrow (BM) samples at relapse both differed from the single clonal TCR gamma rearrangement present in BM obtained at diagnosis 5 years previously.
|
1309670 |
1992 |
|
TRBV20OR9-2
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
An order of TCR gene rearrangements was observed in T-ALL, with the rearrangement of delta gene preceding that of gamma gene.
|
8187567 |
1994 |
|
TRBV20OR9-2
|
0.100 |
Biomarker
|
disease |
BEFREE |
Utilizing the PCR and consensus primers for rearranged immunoglobulin heavy chain (IgH) and T cell receptor gamma (TCR gamma) gene sequences, we analyzed the bone marrow samples at diagnosis and first relapse for 37 children with ALL.
|
7475273 |
1995 |
|
TRBV20OR9-2
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Crosslineage T-cell receptor delta (TCR delta) rearrangements are widely used as tumor markers for the follow up of minimal residual disease in childhood B-precursor acute lymphoblastic leukemia (ALL) by polymerase chain reaction (PCR).
|
7606000 |
1995 |
|
TRBV20OR9-2
|
0.100 |
Biomarker
|
disease |
BEFREE |
We have compared the kinetics of minimal residual disease (MRD) by simultaneous polymerase chain reaction (PCR) monitoring with oligonucleotides for the immunoglobulin heavy chain (IgH) complementarity-determining region 3 (CDR3) and the T-cell receptor gamma chain gene (TCR gamma), as well as clone-specific CDR3 sequences in adult patients (aged 17-51 years) with acute lymphoblastic leukemia (ALL) who entered a complete hematological remission (CR) after chemotherapy with the German multicenter ALL (GMALL) protocol.
|
7578520 |
1995 |
|
TRBV20OR9-2
|
0.100 |
Biomarker
|
disease |
BEFREE |
Simultaneous rearrangement of IgJH and TCR genes was also observed in both cases of biphenotypic ALL (coexpressing B and T markers).
|
7845017 |
1995 |
|
TRBV20OR9-2
|
0.100 |
Biomarker
|
disease |
BEFREE |
PCR using CDR-3 and TCR delta primers can be used as an aid for B lineage ALL diagnosis and clonal evolution of theses disease.
|
9407937 |
1998 |
|
TRBV20OR9-2
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In order to gain insight into immunoglobulin (Ig) and T cell receptor (TCR) gene rearrangements in adult acute lymphoblastic leukemia (ALL), we studied 48 adult patients: 26 with precursor-B-ALL and 22 with T-ALL.
|
9665194 |
1998 |
|
TRBV20OR9-2
|
0.100 |
Biomarker
|
disease |
BEFREE |
The junctional regions of rearranged Ig/TCR genes define the specificity and sensitivity of PCR-based MRD detection in ALL and are generally used to design a patient-specific probe.
|
9844931 |
1998 |
|
TRBV20OR9-2
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Microsatellite markers and fluorescence in situ hybridization identified deletions of the unrearranged TEL allele and IGH/TCR gene rearrangements were analyzed; the results show that posttreatment relapse cells in 2 patients with TEL-AML1-positive ALL were not derived from the dominant clone present at diagnosis but were from a sibling clone.
|
11468150 |
2001 |
|
TRBV20OR9-2
|
0.100 |
Biomarker
|
disease |
BEFREE |
ALF identified monoclonal CDR III amplificates in 55/72 ALL, 23/34 B-NHL, 14/22 MM, and 2/7 MGUS.
|
11489470 |
2001 |
|
TRBV20OR9-2
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Finally, in 1 patient all Ig/TCR gene rearrangements were completely different between diagnosis and relapse, which is suggestive of secondary ALL.
|
11895762 |
2002 |
|
TRBV20OR9-2
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Thirty-four of the 36 children with precursor-B ALL (94%) displayed at least one clonal Ig heavy chain (IgH) or TCR gene sequence useful as a molecular target.
|
12384148 |
2002 |
|
TRBV20OR9-2
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We analyzed the sequences of Ig and TCR gene rearrangements obtained at presentation and relapse in 41 children with ALL to study clonal stability, which has important implications for monitoring MRD, during the course of the disease.
|
12946997 |
2003 |
|
TRBV20OR9-2
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This observation also triggered further screening for TCRB rearrangements in T-ALL.
|
16154840 |
2005 |
|
TRBV20OR9-2
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
TCR genes rearrangements were reported to occur at high frequency in B-lineage acute lymphoblastic leukemia (ALL).
|
16386788 |
2006 |
|
TRBV20OR9-2
|
0.100 |
Biomarker
|
disease |
BEFREE |
In most ALL treatment protocols, MRD diagnostics is performed by real-time quantitative PCR (RQ-PCR) analysis of the junctional regions of rearranged immunoglobulin (Ig) and T-cell receptor (TCR) genes.MRD diagnostics via Ig/TCR genes is broadly applicable (>95% of ALL patients) and can reach a good sensitivity (< or =10 (-4)).
|
19277574 |
2009 |