Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3492
Gene Symbol: IGH
IGH
0.100 Biomarker disease BEFREE CRLF2-d and IGH@-t represent distinct subtypes of adolescent and adult ALL. 22851563 2012
Entrez Id: 3492
Gene Symbol: IGH
IGH
0.100 GeneticVariation disease BEFREE As controversy exists regarding the prognostic significance of genomic rearrangements of CRLF2 in pediatric B-precursor acute lymphoblastic leukemia (ALL) classified as standard/intermediate-risk (SR) or high-risk (HR), we assessed the prognostic significance of CRLF2 mRNA expression, CRLF2 genomic lesions (IGH@-CRLF2, P2RY8-CRLF2, CRLF2 F232C), deletion/mutation in genes frequently associated with high CRLF2 expression (IKZF1, JAK, IL7R), and minimal residual disease (MRD) in 1061 pediatric ALL patients (499 HR and 562 SR) on COG Trials P9905/P9906. 22368272 2012
Entrez Id: 3492
Gene Symbol: IGH
IGH
0.100 GeneticVariation disease BEFREE Using a stepwise molecular approach, we were able to demonstrate that the liver infiltrates were Epstein-Barr virus (EBV)-positive, contained monoclonal mature B-cells with immunoglobulin heavy chain gene (IGH) gene rearrangements unrelated to the primary ALL, and thus represented a true secondary non-Hodgkin lymphoma (NHL). 14966831 2004
Entrez Id: 3492
Gene Symbol: IGH
IGH
0.100 GeneticVariation disease BEFREE The results indicate that the t(14;14)(q11;q32) involving IGH at 14q32 in B-lineage ALL in our cases differ from those reported to involve the TCL1 gene on 14q32.1 in T-cell leukemia associated with AT. 15262434 2004
Entrez Id: 3492
Gene Symbol: IGH
IGH
0.100 Biomarker disease BEFREE The pattern of IgH gene rearrangement analyzed with PCR method in bone marrow from the period of AA diagnosis and in peripheral blood mononuclear cells from ALL diagnosis showed two different monoclonal IgH configurations as the results of biallelic monoclonal rearrangement of IgH genes. 12148900 2002
Entrez Id: 3492
Gene Symbol: IGH
IGH
0.100 Biomarker disease BEFREE Posttreatment relapses, or even very late relapses (5-20 years after diagnosis), in childhood ALL are clonally related to the leukemic cells at diagnosis (by IGH or T-cell receptor [TCR] gene sequencing) and are considered, therefore, to represent a slow re-emergence or escape of the initial clone seen at diagnosis. 11468150 2001
Entrez Id: 3492
Gene Symbol: IGH
IGH
0.100 GeneticVariation disease BEFREE Two types of markers, namely the clone-specific markers including T-cell receptor (TCR) gamma, TCR delta, and Ig heavy-chain (IgH) gene rearrangements, and malignancy-specific fusion gene mRNA such as SIL-TAL-1, BCR-ABL, and HRX-partner genes, were investigated by molecular biology techniques in 65 Chinese patients with acute lymphoblastic leukemia (ALL). 8640718 1996
Entrez Id: 3492
Gene Symbol: IGH
IGH
0.100 GeneticVariation disease BEFREE Using this method we measured the fraction of all-or-none (i.e. positive or negative) reactions of the PCR amplification of the leukemia-specific IgH gene rearrangement in replicate samples of serial dilutions of DNA obtained from diagnostic bone marrow specimens from 15 children with B-precursor acute lymphoblastic leukemia (ALL). 7869771 1995
Entrez Id: 3492
Gene Symbol: IGH
IGH
0.100 GeneticVariation disease BEFREE In contrast, the IgH gene rearrangements were observed only in the B lineage ALL. 8187567 1994
Entrez Id: 3492
Gene Symbol: IGH
IGH
0.100 GeneticVariation disease BEFREE The detection of nonidentical IGH rearrangements suggests that the MLL rearrangement took place in a B-cell precursor or hematopoietic stem cell in one twin which was transferred in utero to the other fetus resulting in ALL with an identical aneuploid karyotype in both infants. 8298125 1994
Entrez Id: 3492
Gene Symbol: IGH
IGH
0.100 GeneticVariation disease BEFREE Multiple IgH gene rearrangements in CML.Ly-BC might take place earlier in the process of IgH gene rearrangements than is the case in B-precursor cell ALL. 1581585 1992
Entrez Id: 3492
Gene Symbol: IGH
IGH
0.100 Biomarker disease BEFREE FL112 and FL114 fetal liver pro-B cells (Stage 0 B-lineage LPC) with germline immunoglobulin heavy chain (IgH) genes but rearranged T-cell receptor gamma (T gamma) genes (DO of FL112 = 80.3 cGy, DO of FL114 = 50.2 cGy), REH ALL pre-pre-B cells (Stage I B-lineage LPC) with rearranged IgH and T gamma genes (DO = 66.1 cGy), and NALM-6 ALL pre-pre-B/pre-B cells (Stage II B-lineage LPC) (DO = 50.5 cGy) corresponding to the earliest three stages of human B-lymphocyte development were the most radiation sensitive B-lineage LPC populations. 1938565 1991
Entrez Id: 3492
Gene Symbol: IGH
IGH
0.100 GeneticVariation disease BEFREE Detection of multiple fragments of IgH genes would be suggestive of multipotent progenitor origin of these ALL. 2114388 1990
Entrez Id: 3492
Gene Symbol: IGH
IGH
0.100 GeneticVariation disease BEFREE The most immature B lineage ALL ('null' ALL) has a much lower frequency of TCR gene rearrangement than the common variant of B cell precursor ALL and also has a high frequency of oligoclonal rearrangements of IgH genes. 3118113 1987
Entrez Id: 3492
Gene Symbol: IGH
IGH
0.100 GeneticVariation disease BEFREE We analyzed rearrangements of the T cell receptor gamma-chain (T gamma) gene as well as rearrangements of the T cell receptor beta-chain (T beta) gene and immunoglobulin heavy-chain (IgH) gene in 68 children with acute lymphoblastic leukemia (ALL). 2823942 1987