Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6962
Gene Symbol: TRBV20OR9-2
TRBV20OR9-2
0.100 AlteredExpression disease BEFREE Seventy-one patients were treated according to the GMALL 07/2003 protocol and evaluated for MRD in bone marrow by specific clonal rearrangements of Ig/TCR in BCR-ABL negative ALL or fusion gene transcript in BCR-ABL positive ALL. 25997106 2016
Entrez Id: 6962
Gene Symbol: TRBV20OR9-2
TRBV20OR9-2
0.100 GeneticVariation disease BEFREE We reasoned that shared clonal rearrangements of IG or TCR genes by concordant ALL in twins would be informative about the fetal cell type in which clonal advantage is elicited by ETV6-RUNX1. 25388957 2015
Entrez Id: 6962
Gene Symbol: TRBV20OR9-2
TRBV20OR9-2
0.100 Biomarker disease BEFREE Acute lymphoblastic leukemia (ALL) cells have unique rearranged immunoglobulin heavy chain (IgH), immunoglobulin light chain (IgK), and T-cell receptor (TCR) genes, which can be used as markers for clonality assay and evaluation of minimal residual disease. 24620952 2014
Entrez Id: 6962
Gene Symbol: TRBV20OR9-2
TRBV20OR9-2
0.100 Biomarker disease BEFREE Quantification of minimal residual disease (MRD) by real-time PCR directed to TCR and Ig gene rearrangements allows a refined evaluation of response in acute lymphoblastic leukemia (ALL). 22442346 2012
Entrez Id: 6962
Gene Symbol: TRBV20OR9-2
TRBV20OR9-2
0.100 Biomarker disease BEFREE Detection of minimal residual disease (MRD) during the treatment of acute lymphoblastic leukemia (ALL) by RQ-PCR analysis of clonal Ig/TCR rearrangements is used for risk group stratification in European treatment protocols. 21596436 2011
Entrez Id: 6962
Gene Symbol: TRBV20OR9-2
TRBV20OR9-2
0.100 Biomarker disease BEFREE In most ALL treatment protocols, MRD diagnostics is performed by real-time quantitative PCR (RQ-PCR) analysis of the junctional regions of rearranged immunoglobulin (Ig) and T-cell receptor (TCR) genes.MRD diagnostics via Ig/TCR genes is broadly applicable (>95% of ALL patients) and can reach a good sensitivity (< or =10 (-4)). 19277574 2009
Entrez Id: 6962
Gene Symbol: TRBV20OR9-2
TRBV20OR9-2
0.100 GeneticVariation disease BEFREE TCR genes rearrangements were reported to occur at high frequency in B-lineage acute lymphoblastic leukemia (ALL). 16386788 2006
Entrez Id: 6962
Gene Symbol: TRBV20OR9-2
TRBV20OR9-2
0.100 GeneticVariation disease BEFREE This observation also triggered further screening for TCRB rearrangements in T-ALL. 16154840 2005
Entrez Id: 6962
Gene Symbol: TRBV20OR9-2
TRBV20OR9-2
0.100 GeneticVariation disease BEFREE We analyzed the sequences of Ig and TCR gene rearrangements obtained at presentation and relapse in 41 children with ALL to study clonal stability, which has important implications for monitoring MRD, during the course of the disease. 12946997 2003
Entrez Id: 6962
Gene Symbol: TRBV20OR9-2
TRBV20OR9-2
0.100 GeneticVariation disease BEFREE Finally, in 1 patient all Ig/TCR gene rearrangements were completely different between diagnosis and relapse, which is suggestive of secondary ALL. 11895762 2002
Entrez Id: 6962
Gene Symbol: TRBV20OR9-2
TRBV20OR9-2
0.100 GeneticVariation disease BEFREE Thirty-four of the 36 children with precursor-B ALL (94%) displayed at least one clonal Ig heavy chain (IgH) or TCR gene sequence useful as a molecular target. 12384148 2002
Entrez Id: 6962
Gene Symbol: TRBV20OR9-2
TRBV20OR9-2
0.100 GeneticVariation disease BEFREE Microsatellite markers and fluorescence in situ hybridization identified deletions of the unrearranged TEL allele and IGH/TCR gene rearrangements were analyzed; the results show that posttreatment relapse cells in 2 patients with TEL-AML1-positive ALL were not derived from the dominant clone present at diagnosis but were from a sibling clone. 11468150 2001
Entrez Id: 6962
Gene Symbol: TRBV20OR9-2
TRBV20OR9-2
0.100 Biomarker disease BEFREE ALF identified monoclonal CDR III amplificates in 55/72 ALL, 23/34 B-NHL, 14/22 MM, and 2/7 MGUS. 11489470 2001
Entrez Id: 6962
Gene Symbol: TRBV20OR9-2
TRBV20OR9-2
0.100 Biomarker disease BEFREE PCR using CDR-3 and TCR delta primers can be used as an aid for B lineage ALL diagnosis and clonal evolution of theses disease. 9407937 1998
Entrez Id: 6962
Gene Symbol: TRBV20OR9-2
TRBV20OR9-2
0.100 GeneticVariation disease BEFREE In order to gain insight into immunoglobulin (Ig) and T cell receptor (TCR) gene rearrangements in adult acute lymphoblastic leukemia (ALL), we studied 48 adult patients: 26 with precursor-B-ALL and 22 with T-ALL. 9665194 1998
Entrez Id: 6962
Gene Symbol: TRBV20OR9-2
TRBV20OR9-2
0.100 Biomarker disease BEFREE The junctional regions of rearranged Ig/TCR genes define the specificity and sensitivity of PCR-based MRD detection in ALL and are generally used to design a patient-specific probe. 9844931 1998
Entrez Id: 6962
Gene Symbol: TRBV20OR9-2
TRBV20OR9-2
0.100 Biomarker disease BEFREE Utilizing the PCR and consensus primers for rearranged immunoglobulin heavy chain (IgH) and T cell receptor gamma (TCR gamma) gene sequences, we analyzed the bone marrow samples at diagnosis and first relapse for 37 children with ALL. 7475273 1995
Entrez Id: 6962
Gene Symbol: TRBV20OR9-2
TRBV20OR9-2
0.100 AlteredExpression disease BEFREE Crosslineage T-cell receptor delta (TCR delta) rearrangements are widely used as tumor markers for the follow up of minimal residual disease in childhood B-precursor acute lymphoblastic leukemia (ALL) by polymerase chain reaction (PCR). 7606000 1995
Entrez Id: 6962
Gene Symbol: TRBV20OR9-2
TRBV20OR9-2
0.100 Biomarker disease BEFREE We have compared the kinetics of minimal residual disease (MRD) by simultaneous polymerase chain reaction (PCR) monitoring with oligonucleotides for the immunoglobulin heavy chain (IgH) complementarity-determining region 3 (CDR3) and the T-cell receptor gamma chain gene (TCR gamma), as well as clone-specific CDR3 sequences in adult patients (aged 17-51 years) with acute lymphoblastic leukemia (ALL) who entered a complete hematological remission (CR) after chemotherapy with the German multicenter ALL (GMALL) protocol. 7578520 1995
Entrez Id: 6962
Gene Symbol: TRBV20OR9-2
TRBV20OR9-2
0.100 Biomarker disease BEFREE Simultaneous rearrangement of IgJH and TCR genes was also observed in both cases of biphenotypic ALL (coexpressing B and T markers). 7845017 1995
Entrez Id: 6962
Gene Symbol: TRBV20OR9-2
TRBV20OR9-2
0.100 GeneticVariation disease BEFREE An order of TCR gene rearrangements was observed in T-ALL, with the rearrangement of delta gene preceding that of gamma gene. 8187567 1994
Entrez Id: 6962
Gene Symbol: TRBV20OR9-2
TRBV20OR9-2
0.100 Biomarker disease BEFREE Using the polymerase chain reaction (PCR) amplification of rearranged T-cell receptor delta(TCR delta)-chain junctional sequences for the preparation of clonospecific probes, we performed a retrospective PCR study of remission bone marrow (BM) samples in seven pediatric patients with ALL who subsequently relapsed (the largest series studied so far) and in 10 patients who were in longterm (greater than 39 to greater than 72 months) remission. 1316978 1992
Entrez Id: 6962
Gene Symbol: TRBV20OR9-2
TRBV20OR9-2
0.100 Biomarker disease BEFREE A case of acute lymphoblastic leukemia (ALL) was encountered in which the two clonal gamma T-cell receptor gene (TCR gamma) rearrangements found in bone marrow (BM) samples at relapse both differed from the single clonal TCR gamma rearrangement present in BM obtained at diagnosis 5 years previously. 1309670 1992
Entrez Id: 6962
Gene Symbol: TRBV20OR9-2
TRBV20OR9-2
0.100 GeneticVariation disease BEFREE Rearrangements of both Ig and TCR genes (double rearrangements) were detected in 24 patients, including three (19%) of 16 T-lineage ALL. 1850056 1991
Entrez Id: 6962
Gene Symbol: TRBV20OR9-2
TRBV20OR9-2
0.100 GeneticVariation disease BEFREE However, concomitant rearrangements of Ig and TcR genes have been commonly reported in the most immature lymphoid malignancies, mainly in B-cell precursor acute lymphoblastic leukemia (ALL). 2331523 1990