Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.200 Biomarker disease BEFREE APOE genotyping was performed in patients with probable Alzheimer's disease (AD) (n=504), frontotemporal dementia (FTD) (n=47), vascular dementia (VaD) (n=152), mixed dementia (n=132), mild cognitive impairment (MCI) (n=44), Parkinson's disease (PD) (n=30), dementia with Lewy bodies (DLB) (n=17), and multisystem atrophy (MSA)/progressive supranuclear palsy (PSP) (n=12). 12876259 2003
Entrez Id: 6622
Gene Symbol: SNCA
SNCA 		0.800 Biomarker disease BEFREE alpha-Synuclein aggregation and toxicity play a major role in Parkinson's disease and dementia with Lewy bodies. 15522241 2004
Entrez Id: 3308
Gene Symbol: HSPA4
HSPA4 		0.020 AlteredExpression disease BEFREE HSP70 mRNA was increased in DLB, whereas the mRNAs for HSP90 and HDJ1 were unchanged. 16319716 2005
Entrez Id: 6667
Gene Symbol: SP1
SP1 		0.010 AlteredExpression disease BEFREE Sp1 transcription factor expression was examined by immunohistochemistry, immunofluorescence and confocal microscopy in Alzheimer disease (AD), Pick disease (PiD), progressive supranuclear palsy (PSP), Parkinson disease (PD) and Dementia with Lewy bodies (DLB). 16378688 2006
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2 		0.100 GeneticVariation disease BEFREE Lrrk2 G2019S was observed in approximately 2% (n = 8) of our Parkinson's disease/Lewy body disease cases (n = 405). 16437559 2006
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2 		0.100 Biomarker disease LHGDN Lrrk2 G2019S was observed in approximately 2% (n = 8) of our Parkinson's disease/Lewy body disease cases (n = 405). 16437559 2006
Entrez Id: 9627
Gene Symbol: SNCAIP
SNCAIP 		0.030 Biomarker disease BEFREE Synphilin-1A is present in Lewy bodies of patients with Parkinson's disease and Diffuse Lewy Body disease, and is observed in detergent-insoluble fractions of brain protein samples obtained from Diffuse Lewy Body disease patients. 16595633 2006
Entrez Id: 6622
Gene Symbol: SNCA
SNCA 		0.800 Biomarker disease BEFREE Alpha-synuclein mutations are much less frequent, but the importance of alpha-synuclein has been confirmed by the demonstration of alpha-synuclein deposition as Lewy bodies in patients with PD and Lewy body dementia. 17563248 2007
Entrez Id: 6622
Gene Symbol: SNCA
SNCA 		0.800 Biomarker disease BEFREE alpha-Synuclein (alpha-syn) is the major component of pathologic inclusions that characterize neurodegenerative disorders such as Parkinson disease, dementia with Lewy body disease, and multiple system atrophy. 18451726 2008
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2 		0.100 Biomarker disease BEFREE Lrrk2 interaction with alpha-synuclein in diffuse Lewy body disease. 19878656 2009
Entrez Id: 6622
Gene Symbol: SNCA
SNCA 		0.800 Biomarker disease BEFREE Alpha-synuclein (alpha-syn) aggregation is a neuropathological hallmark of many diseases including Dementia with Lewy Bodies (DLB) and Parkinson's Disease (PD), collectively termed the alpha-synucleinopathies. 19944097 2010
Entrez Id: 6696
Gene Symbol: SPP1
SPP1 		0.020 GeneticVariation disease BEFREE Osteopontin single-nucleotide polymorphism-66 is associated with Lewy body disease and considered a susceptibility factor. 21469198 2011
Entrez Id: 2629
Gene Symbol: GBA
GBA 		0.500 GeneticVariation disease BEFREE Acid β-glucosidase mutants linked to Gaucher disease, Parkinson disease, and Lewy body dementia alter α-synuclein processing. 21472771 2011
Entrez Id: 2630
Gene Symbol: GBAP1
GBAP1 		0.060 GeneticVariation disease BEFREE Acid β-glucosidase mutants linked to Gaucher disease, Parkinson disease, and Lewy body dementia alter α-synuclein processing. 21472771 2011
Entrez Id: 6622
Gene Symbol: SNCA
SNCA 		0.800 Biomarker disease BEFREE α-Synuclein dysfunction is the critical pathogenic event in Parkinson's disease, multiple system atrophy and dementia with Lewy bodies. 21863007 2011
Entrez Id: 9627
Gene Symbol: SNCAIP
SNCAIP 		0.030 Biomarker disease BEFREE Synphilin-1-binding protein NUB1 is colocalized with nonfibrillar, proteinase K-resistant α-synuclein in presynapses in Lewy body disease. 21937912 2011
Entrez Id: 6622
Gene Symbol: SNCA
SNCA 		0.800 PosttranslationalModification disease BEFREE α-Synuclein is causative for autosomal dominant familial Parkinson disease and dementia with Lewy bodies, and the phosphorylation of α-synuclein at residue Ser-129 is a key posttranslational modification detected in Parkinson disease/dementia with Lewy bodies lesions. 22232559 2012
Entrez Id: 6622
Gene Symbol: SNCA
SNCA 		0.800 Biomarker disease BEFREE α-Synuclein has been reported to be important in modulating brain plasticity and to be a key protein in neurodegenerative diseases, including Lewy body dementia (LBD). 23175842 2012
Entrez Id: 2629
Gene Symbol: GBA
GBA 		0.500 GeneticVariation disease BEFREE GBA1 mutations have been implicated in Lewy body diseases (LBDs), such as Parkinson's disease and dementia with Lewy bodies. 23435096 2013
Entrez Id: 2896
Gene Symbol: GRN
GRN 		0.030 GeneticVariation disease BEFREE GRN Thr272fs clinical heterogeneity: a case with atypical late onset presenting with a dementia with Lewy bodies phenotype. 23478307 2013
Entrez Id: 2896
Gene Symbol: GRN
GRN 		0.030 AlteredExpression disease BEFREE Progranulin plasma levels were analyzed in a variety of FTLD phenotypes (n = 71), dementia of the Alzheimer type (DAT) (n = 22) and probable Lewy body dementia (n = 8), both latter groups presented with asymmetric perisylvian atrophy. 23724906 2013
Entrez Id: 6622
Gene Symbol: SNCA
SNCA 		0.800 Biomarker disease BEFREE α-Synuclein aggregation in neurons is a well-characterized feature of Parkinson's disease and dementia with Lewy bodies. 24502382 2014
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA 		0.010 AlteredExpression disease BEFREE VEGF and FVIIIRA levels were, however, significantly lower in DLB. 24521289 2014
Entrez Id: 6622
Gene Symbol: SNCA
SNCA 		0.800 Biomarker disease BEFREE Alpha-synuclein is a key protein in Parkinson disease (PD) and dementia with Lewy bodies. 25383638 2014
Entrez Id: 6622
Gene Symbol: SNCA
SNCA 		0.800 Biomarker disease BEFREE Alpha-synuclein (αSyn) plays a central role in the pathogenesis of Parkinson's disease (PD) and dementia with Lewy bodies (DLB). 26362253 2015