|
| Entrez Id: |
11277 |
| Gene Symbol: |
TREX1 |
TREX1
|
0.900 |
GeneticVariation
|
disease |
UNIPROT |
The TREX1 C-terminal region controls cellular localization through ubiquitination.
|
23979357 |
2013 |
|
| Entrez Id: |
11277 |
| Gene Symbol: |
TREX1 |
TREX1
|
0.900 |
CausalMutation
|
disease |
CLINVAR |
The TREX1 exonuclease R114H mutation in Aicardi-Goutières syndrome and lupus reveals dimeric structure requirements for DNA degradation activity.
|
21937424 |
2011 |
|
| Entrez Id: |
11277 |
| Gene Symbol: |
TREX1 |
TREX1
|
0.900 |
CausalMutation
|
disease |
CLINVAR |
Evaluation of the TREX1 gene in a large multi-ancestral lupus cohort.
|
21270825 |
2011 |
|
| Entrez Id: |
11277 |
| Gene Symbol: |
TREX1 |
TREX1
|
0.900 |
GeneticVariation
|
disease |
UNIPROT |
Expanding the phenotypic spectrum of lupus erythematosus in Aicardi-Goutières syndrome.
|
20131292 |
2010 |
|
| Entrez Id: |
11277 |
| Gene Symbol: |
TREX1 |
TREX1
|
0.900 |
CausalMutation
|
disease |
CLINVAR |
The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1.
|
20871604 |
2010 |
|
| Entrez Id: |
11277 |
| Gene Symbol: |
TREX1 |
TREX1
|
0.900 |
CausalMutation
|
disease |
CLINVAR |
Expanding the phenotypic spectrum of lupus erythematosus in Aicardi-Goutières syndrome.
|
20131292 |
2010 |
|
| Entrez Id: |
11277 |
| Gene Symbol: |
TREX1 |
TREX1
|
0.900 |
CausalMutation
|
disease |
CLINVAR |
A de novo p.Asp18Asn mutation in TREX1 in a patient with Aicardi-Goutières syndrome.
|
20799324 |
2010 |
|
| Entrez Id: |
11277 |
| Gene Symbol: |
TREX1 |
TREX1
|
0.900 |
GeneticVariation
|
disease |
UNIPROT |
A de novo p.Asp18Asn mutation in TREX1 in a patient with Aicardi-Goutières syndrome.
|
20799324 |
2010 |
|
| Entrez Id: |
11277 |
| Gene Symbol: |
TREX1 |
TREX1
|
0.900 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
New roles for the major human 3'-5' exonuclease TREX1 in human disease.
|
18583934 |
2008 |
|
| Entrez Id: |
11277 |
| Gene Symbol: |
TREX1 |
TREX1
|
0.900 |
CausalMutation
|
disease |
CLINVAR |
The TREX1 double-stranded DNA degradation activity is defective in dominant mutations associated with autoimmune disease.
|
18805785 |
2008 |
|
| Entrez Id: |
11277 |
| Gene Symbol: |
TREX1 |
TREX1
|
0.900 |
CausalMutation
|
disease |
CLINVAR |
Clinical and molecular phenotype of Aicardi-Goutieres syndrome.
|
17846997 |
2007 |
|
| Entrez Id: |
11277 |
| Gene Symbol: |
TREX1 |
TREX1
|
0.900 |
GeneticVariation
|
disease |
UNIPROT |
Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune disease.
|
18045533 |
2007 |
|
| Entrez Id: |
11277 |
| Gene Symbol: |
TREX1 |
TREX1
|
0.900 |
GeneticVariation
|
disease |
CLINVAR |
C-terminal truncations in human 3'-5' DNA exonuclease TREX1 cause autosomal dominant retinal vasculopathy with cerebral leukodystrophy.
|
17660820 |
2007 |
|
| Entrez Id: |
11277 |
| Gene Symbol: |
TREX1 |
TREX1
|
0.900 |
GeneticVariation
|
disease |
UNIPROT |
Heterozygous mutations in TREX1 cause familial chilblain lupus and dominant Aicardi-Goutieres syndrome.
|
17357087 |
2007 |
|
| Entrez Id: |
11277 |
| Gene Symbol: |
TREX1 |
TREX1
|
0.900 |
CausalMutation
|
disease |
CLINVAR |
A mutation in TREX1 that impairs susceptibility to granzyme A-mediated cell death underlies familial chilblain lupus.
|
17440703 |
2007 |
|
| Entrez Id: |
11277 |
| Gene Symbol: |
TREX1 |
TREX1
|
0.900 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 are associated with systemic lupus erythematosus.
|
17660818 |
2007 |
|
| Entrez Id: |
11277 |
| Gene Symbol: |
TREX1 |
TREX1
|
0.900 |
GeneticVariation
|
disease |
UNIPROT |
The crystal structure of TREX1 explains the 3' nucleotide specificity and reveals a polyproline II helix for protein partnering.
|
17293595 |
2007 |
|
| Entrez Id: |
11277 |
| Gene Symbol: |
TREX1 |
TREX1
|
0.900 |
GeneticVariation
|
disease |
UNIPROT |
Clinical and molecular phenotype of Aicardi-Goutieres syndrome.
|
17846997 |
2007 |
|
| Entrez Id: |
11277 |
| Gene Symbol: |
TREX1 |
TREX1
|
0.900 |
CausalMutation
|
disease |
CLINVAR |
The crystal structure of TREX1 explains the 3' nucleotide specificity and reveals a polyproline II helix for protein partnering.
|
17293595 |
2007 |
|
| Entrez Id: |
11277 |
| Gene Symbol: |
TREX1 |
TREX1
|
0.900 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 cause Aicardi-Goutières syndrome at the AGS1 locus.
|
16845398 |
2006 |
|
| Entrez Id: |
11277 |
| Gene Symbol: |
TREX1 |
TREX1
|
0.900 |
CausalMutation
|
disease |
CLINVAR |
Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 cause Aicardi-Goutières syndrome at the AGS1 locus.
|
16845398 |
2006 |
|
| Entrez Id: |
11277 |
| Gene Symbol: |
TREX1 |
TREX1
|
0.900 |
Biomarker
|
disease |
CTD_human |
Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 cause Aicardi-Goutières syndrome at the AGS1 locus.
|
16845398 |
2006 |
|
| Entrez Id: |
11277 |
| Gene Symbol: |
TREX1 |
TREX1
|
0.900 |
GeneticVariation
|
disease |
UNIPROT |
Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 cause Aicardi-Goutières syndrome at the AGS1 locus.
|
16845398 |
2006 |
|
| Entrez Id: |
11277 |
| Gene Symbol: |
TREX1 |
TREX1
|
0.900 |
Biomarker
|
disease |
MGD |
Gene-targeted mice lacking the Trex1 (DNase III) 3'-->5' DNA exonuclease develop inflammatory myocarditis.
|
15254239 |
2004 |
|
| Entrez Id: |
64135 |
| Gene Symbol: |
IFIH1 |
IFIH1
|
0.300 |
Biomarker
|
disease |
CTD_human |
Gain-of-function mutations in IFIH1 cause a spectrum of human disease phenotypes associated with upregulated type I interferon signaling.
|
24686847 |
2014 |