Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.100 GeneticVariation disease BEFREE Methylenetetrahydrofolate reductase (MTHFR) polymorphisms are thought to be involved in the development of cleft lip with or without cleft palate (NSCL/P), but published results are contradictory. 31303355 2019
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.100 GeneticVariation disease BEFREE MTR, MTRR, and MTHFR Gene Polymorphisms and Susceptibility to Nonsyndromic Cleft Lip With or Without Cleft Palate. 27167580 2016
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.100 GeneticVariation disease BEFREE rs1801133C>T polymorphism in MTHFR is a risk factor for nonsyndromic cleft lip with or without cleft palate in the Brazilian population. 25808365 2015
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.100 GeneticVariation disease BEFREE MTHFR rs2274976 polymorphism is a risk marker for nonsyndromic cleft lip with or without cleft palate in the Brazilian population. 24254627 2014
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.100 GeneticVariation disease BEFREE Maternal C677T MTHFR genotype has been identified as important factor in cleft lip with or without cleft palate (CL/P) etiology. 21781437 2013
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.100 GeneticVariation disease BEFREE We found that MTHFR 677 TT and 677 CT/TT were associated with increased risk of cleft lip with or without cleft palate; meanwhile, MTHFR 1298 AC and 1298 AC/CC had protective effects against cleft lip with or without cleft palate. 21612398 2011
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.100 Biomarker disease BEFREE The most significant associations with nonsyndromic cleft lip with or without cleft palate (CL/P) were found for SNPs in MSX1, MTHFR, and PVRL2, including several common haplotypes in the MTHFR and MSX1 genes. 20572854 2010
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.100 GeneticVariation disease BEFREE MTHFR 677TT alone and IRF6 820GG together with MTHFR 677CT, but not MTHFR A1298C, are risks for nonsyndromic cleft lip with or without cleft palate in an Indian population. 19419265 2009
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.100 Biomarker disease BEFREE Maternal MTHFR interacts with the offspring's BCL3 genotypes, but not with TGFA, in increasing risk to nonsyndromic cleft lip with or without cleft palate. 15054400 2004
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.100 GeneticVariation disease BEFREE Maternal MTHFR variant forms increase the risk in offspring of isolated nonsyndromic cleft lip with or without cleft palate. 15221800 2004
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.100 GeneticVariation disease BEFREE Thus, the detrimental effect of low periconceptional folate intake on the risk of giving birth to a CL(P) child was more pronounced in mothers with the MTHFR 677TT or MTHFR 1298CC genotype. 12672677 2003
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.100 GeneticVariation disease BEFREE Because of MTHFR's involvement with folate metabolism and evidence that maternal use of a multivitamin with folic acid in early pregnancy reduces risk for cleft lip with or without cleft palate (CLP), we hypothesized that infants homozygous for the C677T genotype would be at increased risk for CLP because of lower MTHFR enzymatic activity. 9843036 1998