Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4233
Gene Symbol: MET
MET
0.100 Biomarker disease BEFREE MET PET is able to characterize MPM lesions regardless of histology. 31568271 2019
Entrez Id: 4233
Gene Symbol: MET
MET
0.100 Biomarker disease BEFREE <i>ALK</i> overexpression was not associated with gene rearrangement, amplification or kinase-domain mutation. mTOR protein was detected in 28.7% MPM, co-expressed with ALK or MET in 5% and 15% MPM, respectively. 29755689 2018
Entrez Id: 4233
Gene Symbol: MET
MET
0.100 Biomarker disease BEFREE Considered together, the present study has uncovered a novel mechanism underlying mitochondrial regulation by MET that involves crosstalk with DRP1, and suggests that a combination therapy targeting both MET and DRP1 could be a novel strategy for NSCLC and MPM. 30311833 2018
Entrez Id: 4233
Gene Symbol: MET
MET
0.100 AlteredExpression disease BEFREE These data confirm the frequent expression of MET in malignant pleural mesothelioma and demonstrate that this can be targeted effectively and safely using a CAR T-cell immunotherapeutic strategy. 29209570 2017
Entrez Id: 4233
Gene Symbol: MET
MET
0.100 AlteredExpression disease BEFREE DCLK1 is correlated with MET and ERK5 expression, and associated with prognosis in malignant pleural mesothelioma. 28560410 2017
Entrez Id: 4233
Gene Symbol: MET
MET
0.100 AlteredExpression disease BEFREE MET was the most highly overexpressed gene in malignant pleural mesothelioma compared to benign asbestos-related pleural effusion. 25756049 2015
Entrez Id: 4233
Gene Symbol: MET
MET
0.100 Biomarker disease BEFREE EF24 and RAD001 potentiates the anticancer effect of platinum-based agents in human malignant pleural mesothelioma (MSTO-211H) cells and protects nonmalignant mesothelial (MET-5A) cells. 25028262 2015
Entrez Id: 4233
Gene Symbol: MET
MET
0.100 AlteredExpression disease BEFREE Studies have shown that both MET and its key downstream intracellular signaling partners, PI3K and mTOR, are overexpressed in MPM. 25221930 2014
Entrez Id: 4233
Gene Symbol: MET
MET
0.100 Biomarker disease BEFREE Inhibition of Met/HGF receptor and angiogenesis by NK4 leads to suppression of tumor growth and migration in malignant pleural mesothelioma. 20104519 2010
Entrez Id: 4233
Gene Symbol: MET
MET
0.100 AlteredExpression disease BEFREE In small cell lung cancer (SCLC), non-small cell lung cancer (NSCLC), and malignant pleural mesothelioma (MPM), MET is dysregulated via overexpression, constitutive activation, gene amplification, ligand-dependent activation, mutation or epigenetic mechanisms. 18672314 2009
Entrez Id: 4233
Gene Symbol: MET
MET
0.100 Biomarker disease BEFREE c-Met receptor tyrosine kinase (RTK) has not been extensively studied in malignant pleural mesothelioma (MPM). 16397249 2006
Entrez Id: 4233
Gene Symbol: MET
MET
0.100 Biomarker disease BEFREE To investigate a potential therapeutic role for the Met receptor in MPM, we examined the effects of PHA-665752, a specific small-molecule inhibitor of the Met receptor tyrosine kinase, in a panel of 10 MPM cell lines. 16299245 2005