Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
0.070 Biomarker disease BEFREE Recent studies have implicated that PI3K/Akt signaling is involved in MPM cell survival and development. 28960945 2017
Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
0.070 Biomarker disease BEFREE Cell proliferation, viability, apoptosis, mobility, and invasion were determined after siRNA knockdown or YAP (verteporfin), mTOR (rapamycin), and mTOR/PI3K/AKT (PF-04691502) inhibitor treatment.<b>Results:</b> The <i>LATS2</i> gene was altered in 11% of MPM by point mutations and large exon deletions. 28003305 2017
Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
0.070 Biomarker disease BEFREE These findings suggest that the sequential association of palbociclib with PI3K inhibitors may represent a valuable therapeutic option for the treatment of MPM. 28704762 2017
Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
0.070 Biomarker disease BEFREE These novel data reveal a prognostic significance of expression changes of PI3K/mTOR pathway components during induction chemotherapy if confirmed in other patient cohorts and support the growing evidence to target the PI3K/mTOR pathway in the treatment of MPM. 24419422 2014
Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
0.070 Biomarker disease BEFREE GAS5 was upregulated upon growth arrest induced by inhibition of Hedgehog and PI3K/mTOR signalling in in vitro MPM models. 24885398 2014
Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
0.070 AlteredExpression disease BEFREE Studies have shown that both MET and its key downstream intracellular signaling partners, PI3K and mTOR, are overexpressed in MPM. 25221930 2014
Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
0.070 Biomarker disease BEFREE The frequent loss of expression of the tumour suppressor gene PTEN suggests involvement of the PI3K-AKT/protein kinase B (PKB) pathway in MPMs, which may be relevant for future mesothelioma treatment. 18248818 2008