Compared to patients with mild thrombocytosis (platelet count 500-700 × 10<sup>9</sup> /L; n = 27), those with moderate-to-severe thrombocytosis (platelet count >700 × 10<sup>9</sup> /L; n = 33) had significantly higher fibrinogen, factor VIII, and VWF antigen and activity levels; higher endogenous thrombin potential, peak thrombin generation and velocity index levels, and shorter time-to-peak thrombin level.
In summary, this is the first observational study reporting association between higher mortality or thrombotic complications and increased platelet count, increasedVWF:Ag levels and decreased ADAMTS13 activity in colorectal cancer.