Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5444
Gene Symbol: PON1
PON1 		0.300 Biomarker phenotype CTD_human Genetic variants in antioxidant genes are associated with sperm DNA damage and risk of male infertility in a Chinese population. 22206979 2012
Entrez Id: 4193
Gene Symbol: MDM2
MDM2 		0.300 Biomarker phenotype CTD_human Genetic variants in TP53 and MDM2 associated with male infertility in Chinese population. 22773013 2012
Entrez Id: 7157
Gene Symbol: TP53
TP53 		0.300 Biomarker phenotype CTD_human Genetic variants in TP53 and MDM2 associated with male infertility in Chinese population. 22773013 2012
Entrez Id: 339345
Gene Symbol: NANOS2
NANOS2 		0.300 Biomarker phenotype CTD_human Rhox13 is translated in premeiotic germ cells in male and female mice and is regulated by NANOS2 in the male. 22190708 2012
Entrez Id: 29102
Gene Symbol: DROSHA
DROSHA 		0.300 Biomarker phenotype CTD_human Genetic variants in microRNA biogenesis pathway genes are associated with semen quality in a Han-Chinese population. 22381205 2012
Entrez Id: 1831
Gene Symbol: TSC22D3
TSC22D3 		0.300 Biomarker phenotype CTD_human The glucocorticoid-induced leucine zipper (gilz/Tsc22d3-2) gene locus plays a crucial role in male fertility. 22556341 2012
Entrez Id: 6648
Gene Symbol: SOD2
SOD2 		0.300 Biomarker phenotype CTD_human Genetic variants in antioxidant genes are associated with sperm DNA damage and risk of male infertility in a Chinese population. 22206979 2012
Entrez Id: 3948
Gene Symbol: LDHC
LDHC 		0.300 Biomarker phenotype CTD_human Lactate dehydrogenase C and energy metabolism in mouse sperm. 21565994 2011
Entrez Id: 196
Gene Symbol: AHR
AHR 		0.300 Biomarker phenotype CTD_human Assessment of an association between an aryl hydrocarbon receptor gene (AHR) polymorphism and risk of male infertility. 21613234 2011
Entrez Id: 23424
Gene Symbol: TDRD7
TDRD7 		0.300 Biomarker phenotype CTD_human Mutations in the RNA granule component TDRD7 cause cataract and glaucoma. 21436445 2011
Entrez Id: 10047
Gene Symbol: CST8
CST8 		0.300 Biomarker phenotype CTD_human Reduced fertility in vitro in mice lacking the cystatin CRES (cystatin-related epididymal spermatogenic): rescue by exposure of spermatozoa to dibutyryl cAMP and isobutylmethylxanthine. 20811015 2011
Entrez Id: 54898
Gene Symbol: ELOVL2
ELOVL2 		0.300 Biomarker phenotype CTD_human ELOVL2 controls the level of n-6 28:5 and 30:5 fatty acids in testis, a prerequisite for male fertility and sperm maturation in mice. 21106902 2011
Entrez Id: 5444
Gene Symbol: PON1
PON1 		0.300 Biomarker phenotype CTD_human Association between male infertility and genetic variability at the PON1/2 and GSTM1/T1 gene loci. 21561808 2011
Entrez Id: 2099
Gene Symbol: ESR1
ESR1 		0.300 Biomarker phenotype CTD_human Ex3αERKO male infertility phenotype recapitulates the αERKO male phenotype. 20833731 2010
Entrez Id: 2796
Gene Symbol: GNRH1
GNRH1 		0.300 Therapeutic phenotype CTD_human [Testosterone and infertility]. 20063086 2010
Entrez Id: 3973
Gene Symbol: LHCGR
LHCGR 		0.300 Biomarker phenotype CTD_human Transcriptional profiling of luteinizing hormone receptor-deficient mice before and after testosterone treatment provides insight into the hormonal control of postnatal testicular development and Leydig cell differentiation. 20164437 2010
Entrez Id: 2516
Gene Symbol: NR5A1
NR5A1 		0.300 Biomarker phenotype CTD_human Human male infertility associated with mutations in NR5A1 encoding steroidogenic factor 1. 20887963 2010
Entrez Id: 1543
Gene Symbol: CYP1A1
CYP1A1 		0.300 Biomarker phenotype CTD_human Negative effects of serum p,p'-DDE on sperm parameters and modification by genetic polymorphisms. 19303595 2009
Entrez Id: 2879
Gene Symbol: GPX4
GPX4 		0.300 Biomarker phenotype CTD_human Short form glutathione peroxidase 4 is the essential isoform required for survival and somatic mitochondrial functions. 19744930 2009
Entrez Id: 2879
Gene Symbol: GPX4
GPX4 		0.300 Biomarker phenotype CTD_human Mitochondrial glutathione peroxidase 4 disruption causes male infertility. 19417079 2009
Entrez Id: 8085
Gene Symbol: KMT2D
KMT2D 		0.300 Biomarker phenotype CTD_human The histone 3 lysine 4 methyltransferase, Mll2, is only required briefly in development and spermatogenesis. 19348672 2009
Entrez Id: 2054
Gene Symbol: STX2
STX2 		0.300 Biomarker phenotype CTD_human A new ENU-induced mutant mouse with defective spermatogenesis caused by a nonsense mutation of the syntaxin 2/epimorphin (Stx2/Epim) gene. 18277055 2008
Entrez Id: 6414
Gene Symbol: SELENOP
SELENOP 		0.300 Biomarker phenotype CTD_human Hepatic selenoprotein P (SePP) expression restores selenium transport and prevents infertility and motor-incoordination in Sepp-knockout mice. 17961124 2008
Entrez Id: 5428
Gene Symbol: POLG
POLG 		0.300 Biomarker phenotype CTD_human Alpers syndrome with prominent white matter changes. 17923349 2008
Entrez Id: 79730
Gene Symbol: NSUN7
NSUN7 		0.300 Biomarker phenotype CTD_human Sperm motility defects and infertility in male mice with a mutation in Nsun7, a member of the Sun domain-containing family of putative RNA methyltransferases. 17442852 2007