The neocortex could be especially vulnerable to adverse relationships between sleep disorders and aggregation of misfolded α-synuclein and LP formation.
RBD is a parasomnia characterized by dream enactment and by REM sleep without muscle atonia. iRBD is considered as the initial stage of neurodegeneration with pathological storage of alpha-synuclein.
Neuronal expression of familial Parkinson's disease A53Tα-synuclein causes early motor impairment, reduced anxiety and potential sleep disturbances in mice.