Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
0.020 | Biomarker | disease | BEFREE | Of these 12 patients, seven had acute monocytic leukemia (FAB-type M5), two had an M4, two had an M2, and one case of secondary leukemia had an M3-like disorder. | 6576850 | 1983 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | These data provide insight into the dynamics of leukemogenesis in secondary leukemia with MLL rearrangement. | 18932267 | 2009 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | Topoisomerase II (Topo II) inhibitors are cell cycle-specific DNA-damaging agents and often correlate with secondary leukemia with chromosomal translocations involving the mixed-lineage leukemia/myeloid lymphoid leukemia (MLL) gene on chromosome 11 band q23 (11q23). | 16357944 | 2006 | ||||
|
0.080 | Biomarker | disease | BEFREE | In summary, LPP is a newly identified MLL fusion partner in secondary leukemia resulting from topoisomerase inhibitors. | 11433529 | 2001 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | The MLL gene rearrangement is closely associated with secondary leukemia with an 11q23 translocation. | 9846019 | 1998 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | A t(10;11)(p13;q13) chromosomal abnormality that expresses MLL gene rearrangement has not been reported previously in secondary leukemia. | 9648554 | 1998 | ||||
|
0.080 | Biomarker | disease | BEFREE | These results indicate that SJT of ABL and/or CD3 (MLL) genes is associated with the leukemogenesis of secondary leukemia. | 9002963 | 1997 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | Translocation t(4;11)(q21;q23) and MLL gene rearrangement in acute lymphoblastic leukemia secondary to anti topoisomerase II anticancer agents. | 9168451 | 1997 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | These results suggest that site specific cleavage within the MLL bcr induced by topoisomerase II inhibitors may be an early step leading to MLL translocations and secondary leukemia. | 8639880 | 1996 |