Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 885
Gene Symbol: CCK
CCK
0.040 Biomarker disease BEFREE Abnormalities in gallbladder motility function in response to exogenously administered CCK are found primarily in patients with cholesterol gallstones. 28625150 2019
Entrez Id: 885
Gene Symbol: CCK
CCK
0.040 Biomarker disease BEFREE We summarize recent progress on the relationship between coeliac disease and gallstones and propose that coeliac disease is an important risk factor for gallstone formation because defective intestinal cholecystokinin secretion markedly increases susceptibility to cholesterol gallstones via a mechanism involving dysmotility of both the gallbladder and the small intestine. 28186337 2017
Entrez Id: 885
Gene Symbol: CCK
CCK
0.040 AlteredExpression disease BEFREE We postulated that CCK1R function might be defective in such patients due to abnormal membrane composition, such as that observed in cholesterol gallstone disease.<b>Objective:</b> Due to the challenges in directly studying CCK1Rs relevant to appetite control, our goal was to develop and apply a method to determine the impact of a patient's own cellular environment on CCK stimulus-activity coupling and to determine whether CCK sensitivity correlated with the metabolic phenotype of a high-risk population.<b>Design:</b> Wild-type CCK1Rs were expressed on leukocytes from 112 Hispanic patients by using adenoviral transduction and 24-h culture, with quantitation of cholesterol composition and intracellular calcium responses to CCK. 28592602 2017
Entrez Id: 885
Gene Symbol: CCK
CCK
0.040 Biomarker disease BEFREE Down-expression of liver CPE may reduce the secretion of serum CCK and contribute to the formation of cholesterol gallstone. 26228366 2016