Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1440
Gene Symbol: CSF3
CSF3
0.080 Biomarker disease BEFREE Early myeloid-derived suppressor cells (HLA-DR<sup>-</sup>/<sup>low</sup>CD33<sup>+</sup>CD16<sup>-</sup>) expanded by granulocyte colony-stimulating factor prevent acute graft-versus-host disease (GVHD) in humanized mouse and might contribute to lower GVHD in patients post allo-HSCT. 30885244 2019
Entrez Id: 1440
Gene Symbol: CSF3
CSF3
0.080 Biomarker disease BEFREE In summary, our data indicate that G-CSF decreases the M1/M2 ratio in BM grafts from healthy donors, which may contribute to preventing the occurrence of grade 2-4 aGVHD in patients after allo-HSCT. 30683906 2019
Entrez Id: 1440
Gene Symbol: CSF3
CSF3
0.080 Biomarker disease BEFREE We tested the hypothesis that transfusions are associated with the development of severe (grade III-IV) acute graft-versus-host disease (aGVHD) or mortality after allo-HSCT in a retrospective study of 322 consecutive patients receiving an allogeneic bone marrow or granulocyte colony-stimulating factor-mobilized blood stem cell graft for a hematologic malignancy. 29307717 2018
Entrez Id: 1440
Gene Symbol: CSF3
CSF3
0.080 Biomarker disease BEFREE G-CSF could induce the generation of γδTregs in vivo and in vitro, and γδTregs might participate in aGVHD regulation in G-PBSCT. 29801459 2018
Entrez Id: 1440
Gene Symbol: CSF3
CSF3
0.080 Biomarker disease BEFREE Filgrastim had no significant effect on the incidence of acute GVHD, platelet recovery, platelet transfusion requirements, chronic GVHD, or survival. 30036571 2018
Entrez Id: 1440
Gene Symbol: CSF3
CSF3
0.080 Biomarker disease BEFREE Finally, strong G-CSF-induced mobilization of various T cell subsets seemed to increase the risk of recipient acute graft versus host disease, and this was independent of the graft T cell levels. 29770133 2018
Entrez Id: 1440
Gene Symbol: CSF3
CSF3
0.080 Biomarker disease BEFREE Hence, G-CSF is a strong immune regulator of T cells and a promising therapeutic tool in acute graft-versus-host disease as well as in conditions associated with Th1/Th2 imbalance, such as bone marrow failure syndromes and autoimmune diseases. 12676791 2003
Entrez Id: 1440
Gene Symbol: CSF3
CSF3
0.080 Biomarker disease BEFREE Despite a 10-fold increase of T cell dose, the incidence and severity of acute GVHD following allogeneic transplantation of G-CSF-mobilized PBSC is not increased compared to BMT. 10828862 2000