We created humanised mice model for chronic GVHD (cGVHD) by injecting cord blood (CB)-derived human CD34<sup>+</sup>CD38<sup>-</sup>CD45RA<sup>-</sup> haematopoietic stem/progenitor cells (HSPCs) into hIL-6 transgenic NOD/SCID/Il2rgKO (NSG) newborns, and compared GVHD progression with NSG newborns receiving CB CD34<sup>-</sup> cells mimicking acute GVHD.
Our NOD/SCID-beta2m(null) mouse model provides a system to study the pathophysiology of acute GVHD induced by human T cells and aids in development of more effective therapies for human GVHD.