|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
An antigenic but not allelic mismatch at the HLA-DRB1 locus was an independent risk factor for grade ≥2 aGVHD in PTCy (hazard ratio [HR], 2.0; 95% confidence interval [CI], 1.2-4.0; <i>P</i> = .02) but not in ATG regimens (HR, 1.3; 95% CI, 0.4-3.4; <i>P</i> = .6).
|
29296709 |
2017 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Korean adult transplant patients with less than 9 of 10 HLA allele matches in the HLA-A, -B, -C, -DRB1, and DQB1 loci have a higher likelihood of developing acute GVHD (grade II to IV).
|
25553290 |
2015 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
disease |
BEFREE |
HLA-DRB1 and HLA-DQB1 double (DRB1_DQB1) mismatch was revealed to be a significant RR for acute GVHD and mortality, whereas single mismatch was not.
|
25519752 |
2015 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
disease |
BEFREE |
Acute GVHD was positively associated with HLA-A10 (P = 0.0007), HLA-A26 (P = 0.002), B55 (P = 0.001), DRB1*15 (P = 0.0211) and DQB1*05 (P = 0.038), while HLA-B16 (P = 0.0333) was more frequent in patients without acute GVHD.
|
22965361 |
2012 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The risk of acute graft-versus-host disease (GVHD) of these HLA haplotypes was assessed with multivariate Cox regression in 712 patients transplanted from HLA fully (HLA-A, B, C, DRB1, DQB1, and DPB1) matched unrelated donors.
|
20335219 |
2010 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A total of 15 significant high-risk HLA allele mismatch combinations and 1 HLA-DRB1-DQB1 linked mismatch combinations (high-risk mismatch) for severe aGVHD were identified, and the number of high-risk mismatches was highly associated with the occurrence of severe aGVHD regardless of the presence of mismatch combinations other than high-risk mismatch.
|
17554059 |
2007 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Here, we report for the first time that a 30-year-old female acute monocytic leukemia patient with an HLA-A/B recombinant haplotype, who has three unmatched and one HLA-B/DRB1 recombinant haplotype siblings, presented grade IV acute GVHD (aGVHD) after transplantation from a sibling with a single allele only mismatch at the classical HLA-A locus.
|
17990988 |
2007 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
There was no significant association between number of MM (HR) for both HLA-A, -B and -DRB1 and HLA-A, -B, -C, -DRB1 and DQB1 and aGvHD grade II-IV.
|
16247425 |
2005 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These contrary associations of HSP-AA and DRB1*11 with the risk of aGVHD were confirmed using logistic regression modeling in multivariable analysis (HSP-AA, odds ratio [OR] = 3.833, P = 0.004; DRB1*11, OR = 0.224, P = 0.048).
|
15818324 |
2005 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
disease |
BEFREE |
In order to evaluate the impact of HLA-DBP1 incompatibilities on the occurrence of acute graft-versus-host disease (GVHD) in unrelated hematopoietic cell transplantation, we studied 57 donor/recipient pairs characterized by their allelic identity for HLA-A, B, C, DRB1 and DQB1 and also for DRB3, 4, 5 loci and aimed to correlate DPB1 mismatches to already described risk factors for GVHD using multivariate Cox regression analysis.
|
12379888 |
2002 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Single disparities of the HLA-A, -B, -C, or -DRB1 allele were independent risk factors for acute GVHD, and the synergistic effect of the HLA-C allele mismatch with other HLA allele mismatches on acute GVHD was remarkable.
|
12010826 |
2002 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
For patients who underwent transplantation in the first chronic phase (CP) from HLA-A, B matched donors, the presence of DRB1 allele mismatching was independently associated with increased incidence of grades III-IV acute graft-versus-host disease (GVHD).
|
11698272 |
2001 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Tacrolimus does not abrogate the adverse impact of allele mismatching at HLA-DRB1 and HLA-DQB1 on the risk of moderate-to-severe acute GVHD.
|
10816027 |
2000 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Recent studies have demonstrated the importance of recipient HLA-DRB1 allele disparity in the development of acute graft-versus-host disease (GVHD) after unrelated donor marrow transplantation.
|
8986816 |
1996 |