Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.100 AlteredExpression disease BEFREE Mice receiving allogeneic bone marrow and spleen cells displayed symptoms of aGVHD and elevated serum levels of tumor necrosis factor alpha (TNF-α) and interferon gamma (IFN-γ) within 4 days. 31812067 2020
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.100 AlteredExpression disease BEFREE Mice receiving allogeneic bone marrow and spleen cells displayed symptoms of aGVHD and elevated serum levels of tumor necrosis factor alpha (TNF-α) and interferon gamma (IFN-γ) within 4 days. 31812067 2020
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.100 AlteredExpression disease BEFREE We found obviously higher levels of IL-2, IL-4, Elafin, sST2, TLR4, and TNF-α, and lower levels of TGF-β in both aGVHD mouse models and aGVHD patients. 31434801 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.100 Biomarker disease BEFREE We prospectively evaluated the use of the anti-TNFα monoclonal antibody etanercept (ET) as second-line treatment in children with steroid-refractory (SR) aGVHD. 30471340 2019
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.100 AlteredExpression disease BEFREE In our cohort, high peak serum IL-6 level and severe CRS were significantly associated with the development of grade III or IV acute graft-versus-host disease (GVHD). 31195139 2019
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.100 Biomarker disease BEFREE Culture supernatant was used for detection of IL12 and IFNγ of donors' origin.Fourteen patients developed acute GVHD. 31375357 2019
Entrez Id: 6343
Gene Symbol: SCT
SCT
0.100 GeneticVariation disease BEFREE Grade 2-4 acute graft-versus-host disease (GVHD) at 100-day post-DLI was higher in HID-SCT group than that in MSD-SCT group (59.5% vs. 30.8%, p = 0.05). 30747249 2019
Entrez Id: 3115
Gene Symbol: HLA-DPB1
HLA-DPB1
0.100 GeneticVariation disease BEFREE In conclusion, our data suggests that HLA-DPB1 mismatching and CMV reactivation increase risk of aGVHD independently. 30683577 2019
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.100 GeneticVariation disease BEFREE <b>Conclusions:</b> IL6 may contribute to the risk stratification of patients at major risk for aGvHD and TRM, potentially providing a window for additional prophylactic or preemptive strategies to improve the quality of life in the early post-transplant phase and the outcome of allo-HSCT. 31632401 2019
Entrez Id: 3115
Gene Symbol: HLA-DPB1
HLA-DPB1
0.100 Biomarker disease BEFREE Matching status was not associated with overall survival (p = 0.43), relapse (p = 0.21), acute GVHD (p = 0.43), severe aGVHD (p = 0.31), or chronic GVHD (p = 0.23) in univariate analyses, nor in multivariate analyses (p = 0.28, 0.13, 0.29, 0.16, and 0.67, respectively), with or without adjusting for HLA-DPB1 matching status. 29660451 2018
Entrez Id: 3115
Gene Symbol: HLA-DPB1
HLA-DPB1
0.100 Biomarker disease BEFREE Our results suggest avoidance of nonpermissive GVH HLA-DPB1 mismatches for lowering the risk for grade II to IV and III to IV aGVHD. 29386198 2018
Entrez Id: 3115
Gene Symbol: HLA-DPB1
HLA-DPB1
0.100 GeneticVariation disease BEFREE The risk of acute graft-versus-host disease (aGVHD) was analyzed in 1286 patients with single HLA-DPB1 mismatch UR-HCT. 29246901 2018
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.100 AlteredExpression disease BEFREE NK cells produce high levels of IL-10 early after allogeneic stem cell transplantation and suppress development of acute GVHD. 28944953 2018
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.100 GeneticVariation disease BEFREE Furthermore, the IL-6R rs4845618 donor genotype showed an association with severe acute graft-versus-host disease (GVHD), whereas the donor genotype of the IL-6 SNP rs1800795 was associated with decreased survival 100 days post-transplant. 29513361 2018
Entrez Id: 3115
Gene Symbol: HLA-DPB1
HLA-DPB1
0.100 GeneticVariation disease BEFREE The risk of acute graft-versus-host disease (GvHD) after hematopoietic stem cell transplantation is increased with donor-recipient HLA-DPB1 allele mismatching. 29126928 2018
Entrez Id: 5175
Gene Symbol: PECAM1
PECAM1
0.100 Biomarker disease BEFREE To analyze the kinetics of T-cell subsets and thymic function reconstitution after allogeneic hematopoietic stem cell transplantation (AHSCT); to determine whether sjTREC (signal joint TCR rearrangement excision circle) and CD31-positive recent thymic emigrant (CD31 + RTE) are correlated with acute graft versus host disease (aGVHD) or CMV (cytomegalovirus) viremia after AHSCT. 28532344 2018
Entrez Id: 3115
Gene Symbol: HLA-DPB1
HLA-DPB1
0.100 Biomarker disease BEFREE No significant effect of HLA-DPB1 mismatch was observed in the risk of acute GVHD, engraftment or mortality. 28652579 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.100 AlteredExpression disease BEFREE Additionally, we identified a potential role for elevated tumor necrosis factor-α levels in both graft and patient before HSCT in development of aGVHD. 29197674 2018
Entrez Id: 6343
Gene Symbol: SCT
SCT
0.100 Biomarker disease BEFREE The risk of acute graft-versus-host disease (GVHD) is significantly higher after HID-SCT versus ISD-SCT (OR = 1.88, 95% CI = 1.42-2.49, P < 0.00001), but the relapse rate is lower in HID-SCT group (OR = 0.70, 95% CI = 0.55-0.90, P = 0.005). 29381772 2018
Entrez Id: 3107
Gene Symbol: HLA-C
HLA-C
0.100 Biomarker disease BEFREE Administration of DMF significantly alleviated the severity, histological damage, and the overall mortality of aGVHD in an MHC-mismatched aGVHD model. 29209333 2017
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.100 GeneticVariation disease BEFREE An antigenic but not allelic mismatch at the HLA-DRB1 locus was an independent risk factor for grade ≥2 aGVHD in PTCy (hazard ratio [HR], 2.0; 95% confidence interval [CI], 1.2-4.0; <i>P</i> = .02) but not in ATG regimens (HR, 1.3; 95% CI, 0.4-3.4; <i>P</i> = .6). 29296709 2017
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.100 AlteredExpression disease BEFREE HDAC11KO T cells also mediated accelerated onset of acute graft-versus-host disease (GVHD) in a murine model, characterized by increased proliferation of T cells and expression of interferon-γ, tumor necrosis factor, and EOMES. 28550044 2017
Entrez Id: 6343
Gene Symbol: SCT
SCT
0.100 Biomarker disease BEFREE Univariate analysis showed that MRD-WT1 negativity pre-SCT and grade <2 acute GVHD were significant prognostic factors for improved OS and DFS. 29096332 2017
Entrez Id: 3105
Gene Symbol: HLA-A
HLA-A
0.100 GeneticVariation disease BEFREE Incidence of aGVHD and cGVHD was higher in 2 HLA-A locus donor/recipient groups (02: 01/02: 06 and 02: 01/02: 07; p≤0.022). aGVHD incidence was associated with patient age, absence of rabbit anti-thymocyte globulin (ATG) pretreatment, and disease status (p≤0.040). aGVHD appeared to be a risk factor for cGVHD, and total body irradiation (TBI) was also associated with cGVHD. 28652564 2017
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.100 Biomarker disease BEFREE Conversely, IL-6 and IL-10 were greater in aGVHD group, especially after curdlan stimulation (P = .005 and P = .012). 28263922 2017