MDSCs that were generated from murine bone marrow (MDSCs) of wild-type (WT) or <i>Cav1</i><sup>-/-</sup> mice upregulated Cav-1, TLR4 and TLR2 expression after BCG infection on the cell surface.
Our results suggest that miR-21 can negatively modulate the TLR4/MyD88 signaling pathway, resulting in decreased cell viability, increased cell apoptosis and increased levels of inflammatory factors following BCG infection in macrophages.