Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2875
Gene Symbol: GPT
GPT 		0.400 Biomarker phenotype CTD_human Nephrotoxic and hepatotoxic effects of triclosan and chlorhexidine in rats. 145039 1977
Entrez Id: 3440
Gene Symbol: IFNA2
IFNA2 		0.300 Biomarker phenotype CTD_human A phase I study of recombinant human interferon-alpha 2a or human lymphoblastoid interferon-alpha n1 and concomitant zidovudine in patients with AIDS-related Kaposi's sarcoma. 1670585 1991
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.350 Biomarker phenotype CTD_human Antioxidative roles of metallothionein and manganese superoxide dismutase induced by tumor necrosis factor-alpha and interleukin-6. 7532385 1995
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.350 Therapeutic phenotype CTD_human Antioxidative roles of metallothionein and manganese superoxide dismutase induced by tumor necrosis factor-alpha and interleukin-6. 7532385 1995
Entrez Id: 3569
Gene Symbol: IL6
IL6 		0.330 Therapeutic phenotype CTD_human Antioxidative roles of metallothionein and manganese superoxide dismutase induced by tumor necrosis factor-alpha and interleukin-6. 7532385 1995
Entrez Id: 3552
Gene Symbol: IL1A
IL1A 		0.320 Therapeutic phenotype CTD_human The effect of interleukin 1 alpha on acetaminophen-induced hepatotoxicity. 8218930 1993
Entrez Id: 3875
Gene Symbol: KRT18
KRT18 		0.320 GeneticVariation phenotype BEFREE However, transgenic mice that express mutant keratin 18 develop chronic hepatitis, and have an increased susceptibility to drug-induced hepatotoxicity. 9011570 1997
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.350 Biomarker phenotype CTD_human Tumor necrosis factor genomic polymorphism and outcome of acetaminophen (paracetamol)-induced acute liver failure. 9696492 1998
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.350 Therapeutic phenotype CTD_human Tumor necrosis factor genomic polymorphism and outcome of acetaminophen (paracetamol)-induced acute liver failure. 9696492 1998
Entrez Id: 3589
Gene Symbol: IL11
IL11 		0.300 Therapeutic phenotype CTD_human Protective effect of rhIL-11 in a murine model of acetaminophen-induced hepatotoxicity. 11421492 2001
Entrez Id: 6649
Gene Symbol: SOD3
SOD3 		0.300 Therapeutic phenotype CTD_human EC-SOD gene therapy reduces paracetamol-induced liver damage in mice. 11529661 2002
Entrez Id: 2944
Gene Symbol: GSTM1
GSTM1 		0.400 GeneticVariation phenotype BEFREE Increased risk of antituberculosis drug-induced hepatotoxicity in individuals with glutathione S-transferase M1 'null' mutation. 11595069 2001
Entrez Id: 2946
Gene Symbol: GSTM2
GSTM2 		0.350 GeneticVariation phenotype BEFREE Increased risk of antituberculosis drug-induced hepatotoxicity in individuals with glutathione S-transferase M1 'null' mutation. 11595069 2001
Entrez Id: 3627
Gene Symbol: CXCL10
CXCL10 		0.310 Therapeutic phenotype CTD_human IFN-gamma-inducible protein-10 (CXCL10) is hepatoprotective during acute liver injury through the induction of CXCR2 on hepatocytes. 11739529 2001
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.310 Therapeutic phenotype CTD_human These findings suggest that COX-2-derived mediators serve an important hepato-protective function and that COX inhibition may contribute to the risk of drug-induced liver injury, possibly through both nonimmunological and immunological pathways. 11743745 2001
Entrez Id: 10
Gene Symbol: NAT2
NAT2 		0.400 Biomarker phenotype CTD_human Polymorphism of the N-acetyltransferase 2 gene as a susceptibility risk factor for antituberculosis drug-induced hepatitis. 11915035 2002
Entrez Id: 3458
Gene Symbol: IFNG
IFNG 		0.300 Biomarker phenotype CTD_human A pivotal involvement of IFN-gamma in the pathogenesis of acetaminophen-induced acute liver injury. 12153990 2002
Entrez Id: 4254
Gene Symbol: KITLG
KITLG 		0.200 Therapeutic phenotype CTD_mouse Stem cell factor attenuates liver damage in a murine model of acetaminophen-induced hepatic injury. 12594235 2003
Entrez Id: 1571
Gene Symbol: CYP2E1
CYP2E1 		0.400 Biomarker phenotype CTD_human Cytochrome P450 2E1 genotype and the susceptibility to antituberculosis drug-induced hepatitis. 12668988 2003
Entrez Id: 6652
Gene Symbol: SORD
SORD 		0.300 Biomarker phenotype CTD_human Induction of hepatic heme oxygenase-1 by diclofenac in rodents: role of oxidative stress and cytochrome P-450 activity. 12763371 2003
Entrez Id: 9971
Gene Symbol: NR1H4
NR1H4 		0.300 Biomarker phenotype CTD_human [Functional analysis of drug metabolizing enzymes using gene knockout animals]. 12875239 2003
Entrez Id: 1557
Gene Symbol: CYP2C19
CYP2C19 		0.320 Biomarker phenotype CTD_human Association of troglitazone-induced liver injury with mutation of the cytochrome P450 2C19 gene. 12963435 2003
Entrez Id: 9970
Gene Symbol: NR1I3
NR1I3 		0.320 Therapeutic phenotype CTD_human A novel constitutive androstane receptor-mediated and CYP3A-independent pathway of bile acid detoxification. 14742670 2004
Entrez Id: 9970
Gene Symbol: NR1I3
NR1I3 		0.320 Biomarker phenotype CTD_human A novel constitutive androstane receptor-mediated and CYP3A-independent pathway of bile acid detoxification. 14742670 2004
Entrez Id: 1559
Gene Symbol: CYP2C9
CYP2C9 		0.320 Biomarker phenotype CTD_human Leflunomide-induced acute hepatitis. 14971821 2004