Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 10
Gene Symbol: NAT2
NAT2
0.400 GeneticVariation phenotype BEFREE Subset analysis of NAT2 acetylator status and severity grade confirmed these results in AT-DILI patients with more severe disease whereas fast and intermediate acetylator phenotypes were associated with a decreased AT-DILI risk. 31699005 2019
Entrez Id: 10
Gene Symbol: NAT2
NAT2
0.400 GeneticVariation phenotype BEFREE Association of Nat2 Gene Polymorphism with Antitubercular Drug-induced Hepatotoxicity in the Eastern Uttar Pradesh Population. 31245212 2019
Entrez Id: 10
Gene Symbol: NAT2
NAT2
0.400 GeneticVariation phenotype BEFREE Relevance of NAT2 genotype to anti-tuberculosis drug-induced hepatotoxicity in a Chinese Han population. 31066138 2019
Entrez Id: 10
Gene Symbol: NAT2
NAT2
0.400 GeneticVariation phenotype BEFREE The aim of this study is to evaluate the potential association between N-acetyltransferase type 2 (NAT2) polymorphisms and drug-induced liver injury during anti-TB treatment (AT-DILI). 30047605 2018
Entrez Id: 10
Gene Symbol: NAT2
NAT2
0.400 Biomarker phenotype BEFREE NAT2 ultra-slow acetylator and risk of anti-tuberculosis drug-induced liver injury: a genotype-based meta-analysis. 29781872 2018
Entrez Id: 10
Gene Symbol: NAT2
NAT2
0.400 GeneticVariation phenotype BEFREE Two SNPs in NAT2 (rs1041983 and rs1495741) and NAT2 slow acetylators (SA) were significantly associated with INH-DILI (OR (95% CI) = 13.86 (4.30-44.70), 0.10 (0.03-0.33) and 9.98 (3.32-33.80), respectively). 29036176 2017
Entrez Id: 10
Gene Symbol: NAT2
NAT2
0.400 GeneticVariation phenotype BEFREE In conclusion, this study confirms the significance of the association between slow-acetylator NAT2 variants and susceptibility to AT-DILI in an Indonesian population. 26911349 2016
Entrez Id: 10
Gene Symbol: NAT2
NAT2
0.400 GeneticVariation phenotype BEFREE Phenotype frequencies of the NAT2 acetylator in AT-DILI patients were respectively 71.7%, 22.6% and 5.7% for slow, intermediate and rapid acetylators. 27725049 2016
Entrez Id: 10
Gene Symbol: NAT2
NAT2
0.400 GeneticVariation phenotype BEFREE This study was aimed to investigate the role of NAT2 gene polymorphism in anti-tuberculosis drug-induced hepatotoxicity (DIH). 28474630 2016
Entrez Id: 10
Gene Symbol: NAT2
NAT2
0.400 Biomarker phenotype BEFREE Susceptibility of N-acetyltransferase 2 slow acetylators to antituberculosis drug-induced liver injury: a meta-analysis. 26616266 2015
Entrez Id: 10
Gene Symbol: NAT2
NAT2
0.400 Biomarker phenotype BEFREE A recent clinical trial used N-acetyltransferase 2 genotyping to determine the appropriate dose of isoniazid in an anti-tuberculosis therapeutic regimen and demonstrated that pharmacogenetic-based clinical algorithms have the potential to improve efficacy of a drug and to reduce DILI. 25809692 2015
Entrez Id: 10
Gene Symbol: NAT2
NAT2
0.400 Biomarker phenotype CTD_human Key factors of susceptibility to anti-tuberculosis drug-induced hepatotoxicity. 25693865 2015
Entrez Id: 10
Gene Symbol: NAT2
NAT2
0.400 GeneticVariation phenotype BEFREE The NAT2 slow acetylator genotype appears to be a significant risk factor for moderate and severe drug- induced liver injury. 24888881 2014
Entrez Id: 10
Gene Symbol: NAT2
NAT2
0.400 GeneticVariation phenotype BEFREE Though the associations with non-HLA genes have been less well replicated than the HLA associations, there is increasing evidence that drug metabolism genes such as NAT2 and UGT2B7 contribute to some forms of DILI. 24879978 2014
Entrez Id: 10
Gene Symbol: NAT2
NAT2
0.400 GeneticVariation phenotype BEFREE Among the patient-specific determinants of susceptibility to INH-associated DILI, the importance of HLA genetic variants has been increasingly recognized, whereas the role of polymorphisms of drug-metabolizing enzymes (NAT2 and CYP2E1) has become less important and remains controversial. 24783247 2014
Entrez Id: 10
Gene Symbol: NAT2
NAT2
0.400 GeneticVariation phenotype BEFREE The NAT2 tag SNP rs1495741 correlates with the susceptibility of antituberculosis drug-induced hepatotoxicity. 23407048 2013
Entrez Id: 10
Gene Symbol: NAT2
NAT2
0.400 GeneticVariation phenotype BEFREE  NAT2 genetic polymorphisms and anti-tuberculosis drug-induced hepatotoxicity in Chinese community population. 22947533 2013
Entrez Id: 10
Gene Symbol: NAT2
NAT2
0.400 GeneticVariation phenotype BEFREE Slow N-acetyltransferase 2 genotype contributes to anti-tuberculosis drug-induced hepatotoxicity: a meta-analysis. 23277397 2013
Entrez Id: 10
Gene Symbol: NAT2
NAT2
0.400 GeneticVariation phenotype BEFREE Association of N-acetyltransferase 2 and cytochrome P450 2E1 gene polymorphisms with antituberculosis drug-induced hepatotoxicity in Western India. 23875638 2013
Entrez Id: 10
Gene Symbol: NAT2
NAT2
0.400 GeneticVariation phenotype BEFREE To evaluate whether polymorphism of the NAT2 gene was associated with antituberculosis drug-induced hepatotoxicity in Tunisian patients. 21856096 2012
Entrez Id: 10
Gene Symbol: NAT2
NAT2
0.400 GeneticVariation phenotype BEFREE However, the combination of the CYP2E1 C1/C1 genotype with a slow acetylator NAT2 genotype increased the risk of anti-TB drug-induced hepatotoxicity (OR 5.33; P = 0.003) compared with the combination of a rapid acetylator NAT2 genotype with either a C1/C2 or C2/C2 genotype.5. 22506592 2012
Entrez Id: 10
Gene Symbol: NAT2
NAT2
0.400 GeneticVariation phenotype BEFREE NAT2 polymorphisms and susceptibility to anti-tuberculosis drug-induced liver injury: a meta-analysis. 22409928 2012
Entrez Id: 10
Gene Symbol: NAT2
NAT2
0.400 GeneticVariation phenotype BEFREE N-acetyltransferase 2 polymorphisms and risk of anti-tuberculosis drug-induced hepatotoxicity in Caucasians. 22283902 2011
Entrez Id: 10
Gene Symbol: NAT2
NAT2
0.400 Biomarker phenotype BEFREE For genes relevant to drug metabolism, the best replicated association is between isoniazid DILI and NAT2 slow acetylation. 20415545 2010
Entrez Id: 10
Gene Symbol: NAT2
NAT2
0.400 GeneticVariation phenotype BEFREE Conclusive evidence for association with DILI risk has been obtained for non-mutated CYP2E1, slow NAT2 and slow GSTM1 genotypes. 20214588 2009