Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2944
Gene Symbol: GSTM1
GSTM1
0.400 GeneticVariation phenotype BEFREE Previous studies suggest that individuals who are homozygous-null at the GSTM1 or GSTT1 locus may have an increased risk of environmentally related cancers and drug-induced hepatotoxicity. 30471640 2019
Entrez Id: 2944
Gene Symbol: GSTM1
GSTM1
0.400 GeneticVariation phenotype BEFREE Genetic polymorphisms of CYP2E1 and GSTM1 loci and susceptibility to anti-tuberculosis drug-induced hepatotoxicity. 24903797 2014
Entrez Id: 2944
Gene Symbol: GSTM1
GSTM1
0.400 Biomarker phenotype BEFREE Impact of glutathione S-transferase M1 and T1 on anti-tuberculosis drug-induced hepatotoxicity in Chinese pediatric patients. 25525805 2014
Entrez Id: 2944
Gene Symbol: GSTM1
GSTM1
0.400 GeneticVariation phenotype BEFREE GSTM1 and GSTT1 null polymorphisms and susceptibility to anti-tuberculosis drug-induced liver injury: a meta-analysis. 23232001 2013
Entrez Id: 2944
Gene Symbol: GSTM1
GSTM1
0.400 GeneticVariation phenotype BEFREE CYP2E1, GSTM1 and GSTT1 genetic polymorphisms and susceptibility to antituberculosis drug-induced hepatotoxicity: a nested case-control study. 22335459 2012
Entrez Id: 2944
Gene Symbol: GSTM1
GSTM1
0.400 GeneticVariation phenotype BEFREE The roles of GSTM1 and GSTT1 null genotypes and other predictors in anti-tuberculosis drug-induced liver injury. 22845549 2012
Entrez Id: 2944
Gene Symbol: GSTM1
GSTM1
0.400 GeneticVariation phenotype BEFREE Homozygosity for GSTM1 null and/or GSTT1 null alleles also seems to be a risk factor for DILI, with associations described independently for several drugs. 20415545 2010
Entrez Id: 2944
Gene Symbol: GSTM1
GSTM1
0.400 GeneticVariation phenotype BEFREE Conclusive evidence for association with DILI risk has been obtained for non-mutated CYP2E1, slow NAT2 and slow GSTM1 genotypes. 20214588 2009
Entrez Id: 2944
Gene Symbol: GSTM1
GSTM1
0.400 GeneticVariation phenotype BEFREE No significant association was observed between the GSTM1 homozygous null polymorphism and antituberculosis drug-induced hepatotoxicity (OR 0.73, 95% CI 0.31-1.73, P=0.48). 18397238 2008
Entrez Id: 2944
Gene Symbol: GSTM1
GSTM1
0.400 Biomarker phenotype CTD_human The double-null genotype for GSTT1 and GSTM1 might play a role in determining the susceptibility to develop DILI, as a general mechanism that occurs regardless of the type of drug involved, and predominantly in women. 18666253 2008
Entrez Id: 2944
Gene Symbol: GSTM1
GSTM1
0.400 Biomarker phenotype BEFREE The double-null genotype for GSTT1 and GSTM1 might play a role in determining the susceptibility to develop DILI, as a general mechanism that occurs regardless of the type of drug involved, and predominantly in women. 18666253 2008
Entrez Id: 2944
Gene Symbol: GSTM1
GSTM1
0.400 Biomarker phenotype CTD_human Glutathione S-transferase M1 null genotype as a risk factor for carbamazepine-induced mild hepatotoxicity. 17465707 2007
Entrez Id: 2944
Gene Symbol: GSTM1
GSTM1
0.400 GeneticVariation phenotype BEFREE In addition, subjects carrying GSTM1 null genotype had increased risk of anti-tuberculosis DILI (adjusted OR: 2.23, 95% C.I.: 1.07-4.67, P=0.03). 17400324 2007
Entrez Id: 2944
Gene Symbol: GSTM1
GSTM1
0.400 GeneticVariation phenotype BEFREE Increased risk of antituberculosis drug-induced hepatotoxicity in individuals with glutathione S-transferase M1 'null' mutation. 11595069 2001