Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.540 GeneticVariation phenotype BEFREE We found that rs12422149 of SLCO2B1, rs2032582_AT of ABCB1, rs2306283 of SLCO1B1 and rs4148323 of UGT1A1 exhibited a significant association with MMI-DILI; however, no significant difference existed after Bonferroni correction. 31240859 2019
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.540 GeneticVariation phenotype BEFREE The relevance of ABC transporters to drug-induced liver injury is also considered, together with data showing associations of particular ABCB11, ABCB1 and ABCC2 polymorphisms with some forms of drug-induced liver injury. 28028769 2017
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.540 Biomarker phenotype CTD_mouse Inhibition of P-glycoprotein Gene Expression and Function Enhances Triptolide-induced Hepatotoxicity in Mice. 26134275 2015
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.540 GeneticVariation phenotype BEFREE Selected ABCB1, ABCB4 and ABCC2 polymorphisms do not enhance the risk of drug-induced hepatotoxicity in a Spanish cohort. 24732756 2014
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.540 Biomarker phenotype BEFREE Our results demonstrated on the one hand that both MDR1 and MRP2 are variably implicated in idiosyncratic drug-induced liver injury and on the other hand that the occurrence of an inflammatory reaction during idiosyncratic drug therapy can noticeably modulate this implication. 23401306 2013
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.540 Biomarker phenotype CTD_human Phenotypic and genotypic assessment of concomitant drug-induced toxic effects in liver, kidney and blood. 20623750 2011
Entrez Id: 761
Gene Symbol: CA3
CA3
0.500 Biomarker phenotype CTD_human Characteristic molecular and proteomic signatures of drug-induced liver injury in a rat model. 25231249 2015
Entrez Id: 761
Gene Symbol: CA3
CA3
0.500 Biomarker phenotype CTD_mouse Characterization of chemically induced liver injuries using gene co-expression modules. 25226513 2014
Entrez Id: 2875
Gene Symbol: GPT
GPT
0.400 GeneticVariation phenotype BEFREE As a result, the ABCC2 rs3740065 genotype, sex, and the baseline level of alanine aminotransferase are independent risk factors of antituberculosis drug-induced hepatotoxicity, with P values of .008, .014, and <.001, respectively. 31648372 2020
Entrez Id: 1571
Gene Symbol: CYP2E1
CYP2E1
0.400 GeneticVariation phenotype BEFREE Relationship of anti-tuberculosis drug-induced liver injury and genetic polymorphisms in CYP2E1 and GST. 31697922 2020
Entrez Id: 406906
Gene Symbol: MIR122
MIR122
0.400 Biomarker phenotype BEFREE However, miR-122-5p, -192-5p, -34a-5p and -22-3p demonstrated a much more significant induction in patients with hepatocellular DILI, thus revealing better specificity for hepatocellular damage. 31198949 2020
Entrez Id: 1571
Gene Symbol: CYP2E1
CYP2E1
0.400 AlteredExpression phenotype BEFREE Increased expression of CYP2E1 may represent the main factor contributing to oxidative stress-mediated liver damage in drug-induced liver injury (DILI). 31468699 2020
Entrez Id: 10
Gene Symbol: NAT2
NAT2
0.400 GeneticVariation phenotype BEFREE Subset analysis of NAT2 acetylator status and severity grade confirmed these results in AT-DILI patients with more severe disease whereas fast and intermediate acetylator phenotypes were associated with a decreased AT-DILI risk. 31699005 2019
Entrez Id: 2875
Gene Symbol: GPT
GPT
0.400 Biomarker phenotype BEFREE Using these data, we derived a novel parameter, P<sub>ALT</sub>  = ALT_AUC*Peak ALT<sup>0.18</sup> /10<sup>5</sup> ((IU/L)<sup>2</sup> *h), where AUC is area under the curve, that correlated well with hepatocyte loss estimates derived by DILIsym in patients with DILI due to six different hepatotoxic drugs. 30303523 2019
Entrez Id: 10
Gene Symbol: NAT2
NAT2
0.400 GeneticVariation phenotype BEFREE Association of Nat2 Gene Polymorphism with Antitubercular Drug-induced Hepatotoxicity in the Eastern Uttar Pradesh Population. 31245212 2019
Entrez Id: 1571
Gene Symbol: CYP2E1
CYP2E1
0.400 Biomarker phenotype BEFREE Cytochrome P450 2E1 (CYP2E1) plays a vital role in drug-induced hepatotoxicity and cancers (e.g. lung and bladder cancer), since it is responsible for metabolizing a number of medications and environmental toxins to reactive intermediate metabolites. 31203697 2019
Entrez Id: 2875
Gene Symbol: GPT
GPT
0.400 Biomarker phenotype BEFREE RUCAM criteria were defined as the gold standard, and the other two criteria were as follows: 1) ALT or aspartate aminotransferase (AST) levels greater than 5 × the ULN on two consecutive occasions and/or ALP levels greater than 2 × the ULN on two consecutive occasions [issued by DILI Network (DILIN)]; 2) ALT levels greater than 1 × the ULN on two consecutive occasions or ALT levels greater than 2 × the ULN [issued by the National Medical Products Administration (NMPA) of China]. 31379581 2019
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.400 Biomarker phenotype BEFREE We found no HLA-B*57 association with DILI due to other isoxazolyl penicillins (n = 6) or amoxicillin (n = 15) and no significant non-HLA signals for any penicillin-related DILI. 30661239 2019
Entrez Id: 2944
Gene Symbol: GSTM1
GSTM1
0.400 GeneticVariation phenotype BEFREE Previous studies suggest that individuals who are homozygous-null at the GSTM1 or GSTT1 locus may have an increased risk of environmentally related cancers and drug-induced hepatotoxicity. 30471640 2019
Entrez Id: 406906
Gene Symbol: MIR122
MIR122
0.400 Biomarker phenotype BEFREE Conclusion: GLDH appears to be more useful than miR-122 in identifying DILI patients, and K18, OPN, and MCSFR are promising candidates for prediction of prognosis during an acute DILI event. 29357190 2019
Entrez Id: 10
Gene Symbol: NAT2
NAT2
0.400 GeneticVariation phenotype BEFREE Relevance of NAT2 genotype to anti-tuberculosis drug-induced hepatotoxicity in a Chinese Han population. 31066138 2019
Entrez Id: 1571
Gene Symbol: CYP2E1
CYP2E1
0.400 Biomarker phenotype BEFREE Volatile anaesthetics are known to cause drug-induced liver injury, a hepatotoxic reaction characterised by antibodies to trifluoroacetylated lipid and protein adducts and cytochrome p450 2E1. 30761577 2019
Entrez Id: 2875
Gene Symbol: GPT
GPT
0.400 Biomarker phenotype BEFREE There was one reported case in which raised ALT occurred with raised bilirubin, meeting criteria for moderate drug-induced liver injury. 30620055 2019
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.400 Biomarker phenotype BEFREE In the pilot study, the frequency of HLA-B*35:01 was 45.4% in PM-DILI patients compared with 2.7% in the Han Chinese population (odds ratio [OR], 30.4; 95% confidence interval [CI], 11.7-77.8; P = 1.9 × 10<sup>-10</sup> ). 30985007 2019
Entrez Id: 2875
Gene Symbol: GPT
GPT
0.400 Biomarker phenotype BEFREE Changes in the serum alanine aminotransferase (ALT) concentrations after starting corticosteroid treatment were determined and compared between the DILI and AIH groups. 31319011 2019