Herein, we present cytogenetic and molecular analysis of a case of B-ALL in a 16-year-old Caucasian boy with t(3;9) FOXP1-ABL1 rearrangement and concurrent loss of IKZF1, CDKN2A, and RB1 gene loci, meeting WHO criteria for Ph-like ALL.
These include <i>CRLF2</i> and <i>PAX5</i> alterations<i>, TP53, CREBBP</i> and <i>ERG</i> mutations, characteristic genetic aberrations in BCR-ABL1-like B-ALL and others.
CD25 expression is associated with t(9;22)(q34;q11)/Philadelphia chromosome translocation (Ph); BCR-ABL1 rearrangement in B lymphoblastic leukemia/lymphoma (B-LL).