Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 51332
Gene Symbol: SPTBN5
SPTBN5
0.100 GeneticVariation disease GWASCAT A Genome-Wide Functional Genomics Approach Identifies Susceptibility Pathways to Fungal Bloodstream Infection in Humans. 31241743 2019
Entrez Id: 64170
Gene Symbol: CARD9
CARD9
0.020 AlteredExpression disease BEFREE Thus, Dok3 suppresses Card9 signaling, and disrupting Dok3-Card9 interaction or inhibiting PP1 activity represents therapeutic opportunities to develop drugs to combat candidaemia. 31180338 2019
Entrez Id: 79930
Gene Symbol: DOK3
DOK3
0.010 AlteredExpression disease BEFREE Thus, Dok3 suppresses Card9 signaling, and disrupting Dok3-Card9 interaction or inhibiting PP1 activity represents therapeutic opportunities to develop drugs to combat candidaemia. 31180338 2019
Entrez Id: 4680
Gene Symbol: CEACAM6
CEACAM6
0.010 Biomarker disease BEFREE Candidemia following NCA in neonates (p = 0.02), infants (p = 0.04) and adults (p = 0.02) in ICU and immunocompromised patients were significantly higher. 31226938 2019
Entrez Id: 3732
Gene Symbol: CD82
CD82
0.010 GeneticVariation disease BEFREE CD82 knockout mice were more susceptible to <i>C. albicans</i> as compared with wild-type mice.Furthermore, patient <i>C. albicans</i>-induced cytokine production was influenced by two human CD82 single nucleotide polymorphisms, whereas an additional CD82 single nucleotide polymorphism increased the risk for candidemia independent of cytokine production. 31010852 2019
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.010 Biomarker disease BEFREE Compared to wild type mice, Nos3-/- mice showed significantly higher survival of candidemia caused by Candida albicans SC5314. 31671151 2019
Entrez Id: 100137049
Gene Symbol: PLA2G4B
PLA2G4B
0.010 GeneticVariation disease BEFREE We observed strong association between candidemia and a variant, rs8028958, that significantly affects the expression levels of PLA2G4B in blood. 31241743 2019
Entrez Id: 1089
Gene Symbol: CEACAM4
CEACAM4
0.010 Biomarker disease BEFREE Candidemia following NCA in neonates (p = 0.02), infants (p = 0.04) and adults (p = 0.02) in ICU and immunocompromised patients were significantly higher. 31226938 2019
Entrez Id: 9398
Gene Symbol: CD101
CD101
0.040 Biomarker disease BEFREE Rezafungin (CD101) is a novel echinocandin antifungal agent currently in clinical development for the treatment of candidemia and invasive candidiasis. 29555631 2018
Entrez Id: 9398
Gene Symbol: CD101
CD101
0.040 Biomarker disease BEFREE CD101 is currently being evaluated as a once-weekly intravenous (i.v.) infusion for the treatment of candidemia and invasive candidiasis. 29133552 2018
Entrez Id: 8864
Gene Symbol: PER2
PER2
0.020 Biomarker disease BEFREE The proportion of patients receiving treatment increased (65.5%, 79.4% and 74.7% in periods 1, 2 and 3, respectively, p = 0.04), and the median time from candidemia to treatment initiation decreased from 4 days in period 1 (range 0-32 days) to 2 days in period 2 (range 0-33 days) and 2 days in period 3 (range 0-14 days, p < 0.001). 30118654 2018
Entrez Id: 8864
Gene Symbol: PER2
PER2
0.020 Biomarker disease BEFREE The study period was split into two periods, 2007 to 2010 (period 1) and 2011 to 2014 (period 2).The number of episodes of <i>C. albicans</i> and <i>C. parapsilosis</i> candidemia (<i>n</i> = 262 versus <i>n</i> = 170, respectively), the mean incidence (1.62 versus 1.36 episodes per 1,000 admissions, respectively), and the percentage of episodes caused by clusters (overall clusters [40% versus 12%] and tracking clusters [18% versus 3%], respectively) were significantly lower in period 2 than in period 1. 29743306 2018
Entrez Id: 10563
Gene Symbol: CXCL13
CXCL13
0.010 Biomarker disease BEFREE In conclusion, our results indicated that CXCL13 had strong potential as a novel biomarker of diagnosis and prognosis for candidemia. 29198822 2018
Entrez Id: 796
Gene Symbol: CALCA
CALCA
0.010 AlteredExpression disease BEFREE Moreover, we observed that high PCT and BDG levels as well as low PLT counts were also associated with mortality from candidemia. 30030692 2018
Entrez Id: 7389
Gene Symbol: UROD
UROD
0.010 AlteredExpression disease BEFREE Moreover, we observed that high PCT and BDG levels as well as low PLT counts were also associated with mortality from candidemia. 30030692 2018
Entrez Id: 9398
Gene Symbol: CD101
CD101
0.040 Biomarker disease BEFREE CD101 IV is a novel echinocandin with distinctive pharmacokinetic properties that is being developed as a once-weekly treatment for candidemia and invasive candidiasis. 27919901 2017
Entrez Id: 9398
Gene Symbol: CD101
CD101
0.040 Biomarker disease BEFREE CD101, a novel echinocandin with a long plasma half-life and enhanced stability, is in development for once-weekly IV administration for the treatment of candidemia and invasive candidiasis. 28826987 2017
Entrez Id: 284697
Gene Symbol: BTBD8
BTBD8
0.010 GeneticVariation disease BEFREE Based on logistic regression modelling, admission to north Indian ICUs [OR 2.1 (1.2-3.8); P  =   0.012], public-sector hospital [OR 2.2 (1.2-3.9); P  =   0.006], underlying respiratory illness [OR 2.1 (1.3-3.6); P  =   0.002], vascular surgery [OR 2.3 (1.00-5.36); P  =   0.048], prior antifungal exposure [OR 2.8 (1.6-4.8); P  <   0.001] and low APACHE II score [OR 0.8 (0.8-0.9); P  =   0.007] were significantly associated with C. auris candidaemia. 28333181 2017
Entrez Id: 11331
Gene Symbol: PHB2
PHB2
0.010 GeneticVariation disease BEFREE ICU-acquired candidaemia in France: Epidemiology and temporal trends, 2004-2013 - A study from the REA-RAISIN network. 28366686 2017
Entrez Id: 10451
Gene Symbol: VAV3
VAV3
0.010 GeneticVariation disease BEFREE In this context, Vav3 is the single most important Vav in mice, and a polymorphism in human VAV3 is associated with susceptibility to candidemia in patients. 27926862 2016
Entrez Id: 51280
Gene Symbol: GOLM1
GOLM1
0.010 GeneticVariation disease BEFREE Among them, a cytokine QTL at the NAA35-GOLM1 locus markedly modulated interleukin (IL)-6 production in response to multiple pathogens and was associated with susceptibility to candidemia. 27376574 2016
Entrez Id: 60560
Gene Symbol: NAA35
NAA35
0.010 GeneticVariation disease BEFREE Among them, a cytokine QTL at the NAA35-GOLM1 locus markedly modulated interleukin (IL)-6 production in response to multiple pathogens and was associated with susceptibility to candidemia. 27376574 2016
Entrez Id: 53828
Gene Symbol: FXYD4
FXYD4
0.010 Biomarker disease BEFREE Candida parapsilosis was the most common species causing candidemia in the 2010 China Hospital Invasive Fungal Surveillance Net (CHIF-NET) database. 26282840 2015
Entrez Id: 10926
Gene Symbol: DBF4
DBF4
0.010 Biomarker disease BEFREE Candida parapsilosis was the most common species causing candidemia in the 2010 China Hospital Invasive Fungal Surveillance Net (CHIF-NET) database. 26282840 2015
Entrez Id: 25870
Gene Symbol: SUMF2
SUMF2
0.010 Biomarker disease BEFREE Lactobacillus bacteremia was associated with candidemia and occurred while the patient was receiving a probiotic formulation containing the same strain (as determined by PFGE typing), and was being concomitantly treated with i.v. vancomycin, to which the Lactobacillus strain was resistant. 26024568 2015